Iodine Fixation in the Thyroid as Influenced by the Hypophysis and Other Factors

Leblond, C. P.; Sue, P.

doi:10.1152/ajplegacy.1941.134.3.549

Cited by 59 publications

(12 citation statements)

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“…Goldsmith, Stanbury, and Brownell have recently demonstrated that the injection of preparations of this material causes an increase in the rate of release of hormone from the thyroid gland (6). Studies on the rat and chick have demonstrated similar changes (7)(8)(9)(10).…”

mentioning

confidence: 94%

The Effect of a Thyrotrophic Hormone Preparation on the Metabolism of Radioiodine in Euthyroid, Hyperthyroid and Acromegalic Individuals 1

Becker¹,

Rall²,

Peacock³

et al. 1953

J. Clin. Invest.

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mentioning

confidence: 94%

The Effect of a Thyrotrophic Hormone Preparation on the Metabolism of Radioiodine in Euthyroid, Hyperthyroid and Acromegalic Individuals 1

Becker¹,

Rall²,

Peacock³

et al. 1953

J. Clin. Invest.

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“…Radioiodine tracers have subsequently been utilized in many studies dealing with the thyroid of laboratory animals, in vitro experiments and clinical investigations. The method has been applied to the study of the biosynthesis of thyroid hormone (1, 3 to 9), the action of thyrotrophic hormones (4,10), the action of goitrogens (5,11) and of other factors influencing the function of the thyroid (6), the functional activity of various thyroid tumors and a number of other problems.…”

mentioning

confidence: 99%

The Urinary Excretion of Radioiodine in Various Thyroid States

Mh²,

Berkson³

et al. 1947

J. Clin. Invest.

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Radioiodine and natural iodine are chemically and physiologically identical, providing the former is present in quantities so small as to be without biologic effects due to radiation per se. A minute quantity of radioiodine may be used to trace, by its radioactivity, the course of a given quantity of iodine through various chemical and biologic reactions. Hertz (1, 2) was the first to call attention to the unique possibilities of this method in the study of thyroid function. Hamilton and Soley ( 12) were the first to apply it to the clinical investigation of the human thyroid. Radioiodine tracers have subsequently been utilized in many studies dealing with the thyroid of laboratory animals, in vitro experiments and clinical investigations. The method has been applied to the study of the biosynthesis of thyroid hormone (1, 3 to 9), the action of thyrotrophic hormones (4, 10), the action of goitrogens (5, 11) and of other factors influencing the function of the thyroid (6), the functional activity of various thyroid tumors and a number of other problems.It is possible that radioiodine may prove most useful in the study of thyroid function in man. To date, relatively few definitive clinical studies employing this technique have been published. The first was that of Hamilton and Soley (12), who compared the collection by the thyroid of iodine labeled with radioiodine and its excretion in the urine and feces in normal subjects and in patients having various thyroid disorders. Radioiodine in the thyroid was measured directly by the recording of its gamma radiation by means of a Geiger-Muller counter placed over the trachea and in some instances by analysis of surgically removed specimens of thyroid tissue. It was found that an orally administered dose of labeled iodine was absorbed very rapidly and could be detected in the thyroid within 20 minutes. Normal subjects excreted 74 to 89 per cent of the dose in the urine during a period of 5 days, 53 to 81 per cent appearing during the first 24 hours. Two myxedematous patients excreted 91 and 94 per cent, respectively, in the urine during 5 days but at a slower rate than did the normals. Patients who had hyperthyroidism excreted as much in the urine as did the normals. This finding may have been due to the fact that most of the patients had received strong solution of iodine (Lugol's solution) and in part to the very large amount of iodide (14 mgm.) which was administered as a labeled dose. Fecal excretion was variable but averaged only about 1 per cent of the dose.In another series of in vivo measurements employing the same dose of iodide, Hamilton and Soley (13) recorded characteristic collection curves for various thyroid states. The curve typical of normal thyroids was a smooth curve which leveled off to a flat plateau in 2 days. Iodine collection by thyroids of hyperthyroid patients was greater and much more rapid than in normal thyroids. It rose to a peak within 4 to 8 hours and thereafter decreased almost as rapidly to a plateau lower than that of the normal thyro...

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“…The rate at which organic binding and coupling goes on depends on the state of activity of the gland, and is accelerated by thyrotropin (50) and exposure to cold (51), slowed by hypophysectomy (4,52), and influenced by the previous iodide level (36). The rate is also affected by the iodide concentration at any moment (32), as noted below.…”

Section: Organic Binding and Hormone Synthesismentioning

confidence: 98%

“…This assumption is perhaps unnecessary, however, since it has been found repeatedly that diiodotyrosine is rapidly destroyed in the body. Thus, Leblond and Sue (4) when the radioactivity first appears in the proteinbound iodine, it is predominantly in the diiodotyrosine-like fraction; later, it is chiefly in the thyroxine-like component (50).…”

Section: Hormone Secretionmentioning

confidence: 99%

“…Harington, by 1944, (101) was satisfied that the peptide concept was no longer necessary. The concept of thyroxine as the hormone per se has received further support from the work of Taurog and Chaikoff (102), who showed that almost all the organic iodine in plasma behaves like thyroxine in that it: (1) precipitates with the protein, (2) from which it cannot be dialyzed, (3) but from which it is readily extracted with butyl alcohol, (4) in which it remains after extraction with 4N NaOH -5 per cent Na2CO3. In addition, when a rat has labelled its plasma organic iodine from a previous injection of I181, the radioactivity follows added thyroxine carrier.…”

Section: Hormone Secretionmentioning

confidence: 99%

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The Use of Radioiodine in Physiological and Clinical Studies on the Thyroid Gland

Raben¹,

Astwood²

1949

J. Clin. Invest.

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Iodine Fixation in the Thyroid as Influenced by the Hypophysis and Other Factors

Cited by 59 publications

References 0 publications

The Effect of a Thyrotrophic Hormone Preparation on the Metabolism of Radioiodine in Euthyroid, Hyperthyroid and Acromegalic Individuals 1

The Effect of a Thyrotrophic Hormone Preparation on the Metabolism of Radioiodine in Euthyroid, Hyperthyroid and Acromegalic Individuals 1

The Urinary Excretion of Radioiodine in Various Thyroid States

The Use of Radioiodine in Physiological and Clinical Studies on the Thyroid Gland

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