Iodine Deficiency in Pregnancy as a Predictor of Sub-clinical Hypothyroidism, Preeclampsia and Future Cardiovascular Disease

Businge, Charles Bitamazire; Longo-Mben, Benjamin; Adeniyi, Oladele Vincent; Babe, Victor Nzuzi; Kitambala, Achille; Muak, Moise Mvitu; Nk, Mireille Solange; Ts, Christophe Masiala; Vangu, Roland Vangu; Di, Emmanuel Mabiala; Goon, Daniel Ter

doi:10.3923/ajcn.2017.118.123

Cited by 4 publications

(4 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, low urinary iodine concentration, low serum thyroxine and high serum thyroglobulin were independent predictors of hypertensive disease in pregnancy in the study population. These findings correlate with previous case-control studies that reported a positive association between insufficient iodine intake and preeclampsia [ 12 , 30 , 31 ]. A recent systematic review found a significant difference in the mean UIC of preeclamptic and normotensive pregnant controls but no increased risk of preeclampsia among pregnant women with UIC < 150 μg/L in the included cohort studies [ 32 ].…”

Section: Discussionsupporting

confidence: 91%

Iodine deficiency in pregnancy along a concentration gradient is associated with increased severity of preeclampsia in rural Eastern Cape, South Africa

Businge

Longo-Mbenza

Kengne

2022

BMC Pregnancy Childbirth

Self Cite

View full text Add to dashboard Cite

Background Preeclampsia is a leading cause of maternal mortality and morbidity in South Africa. Iodine deficiency in pregnancy, which is amenable to correction through iodine supplementation, has been reported to increase the risk of preeclampsia. However, the association of iodine nutrition status with preeclampsia in South Africa has not been studied. Methods We enrolled 51 randomly selected normotensive pregnant controls at term together with 51 consecutively selected cases of preeclampsia and 51 cases of severe preeclampsia/eclampsia, all in the third trimester, from Mthatha Regional and Nelson Mandela Academic Hospital in the Eastern Cape Province. Urinary iodine concentration (UIC), serum thyroid-stimulating hormone (TSH), triiodothyronine (FT3), thyroxine (FT4) and thyroglobulin (Tg) levels were compared between cases and controls. Results The respective chronological and gestational ages at enrolment for normotensive, preeclampsia and severe preeclampsia/eclampsia participants were: age 23, 24 and 19 years (p = 0.001), and gestational age 38, 34, and 35 weeks (p < 0.001). The median gravidity was 1 for all three groups. The median UIC, FT4, FT3 revealed a decreasing and Tg a rising trend with the severity of preeclampsia (p < 0.05). TSH had a non-significant rising trend (p > 0.05). The respective median values for normotensive, preeclampsia and severe preeclampsia/eclampsia participants were UIC 217.1, 127.7, and 98.8 μg/L; FT4 14.2, 13.7, and 12. pmol/L; FT3 4.8, 4.4, and 4.0 pmol//L; Tg 19.4, 21.4, and 32. Nine microgram per liter; TSH 2.3, 2.3, and 2.5 mIU/L. UIC < 100 μg/L, Tg > 16 μg/L and FT4 < 11.3 pmol/L were independent predictors of preeclampsia/eclampsia syndrome. Conclusion Women with severe preeclampsia/eclampsia had significantly low UIC and high Tg, suggesting protracted inadequate iodine intake. Inadequate iodine intake during pregnancy severe enough to cause elevated Tg and FT4 deficiency was associated with an increased risk of severe preeclampsia/eclampsia.

show abstract

Section: Discussionsupporting

confidence: 91%

Iodine deficiency in pregnancy along a concentration gradient is associated with increased severity of preeclampsia in rural Eastern Cape, South Africa

Businge

Longo-Mbenza

Kengne

2022

BMC Pregnancy Childbirth

Self Cite

View full text Add to dashboard Cite

show abstract

“…Three were institutional-based case-control studies one from the countries Turkey, Mexico and the Democratic Republic of Congo, while two were prospective cohort studies that were from two different provinces (Henan and Liaoning) in China. [23][24][25][26][27][28] Meta-analysis Mean difference in UIC of pre-eclamptic and normotensive women Three studies reported the mean UIC of pre-eclamptic and normotensive pregnant women. [23][24][25] Overall, there was a significant and positive mean difference in UIC and standardised mean UIC of normotensive pregnant women and pre-eclamptic women, with substantial heterogeneity across studies (figure 2).…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…America. [23][24][25] This association between low UIC and pre-eclampsia may reflect inadequate iodine intake predating pregnancy persisting until the third trimester that may increase the risk of pre-eclampsia among susceptible women. A recent Norwegian Study reported that among women with mild to moderate deficiency, long-term preconception iodine supplementation was associated with reduced incidence of pre-eclampsia.…”

Section: Open Accessmentioning

confidence: 99%

Insufficient iodine nutrition status and the risk of pre-eclampsia: a systemic review and meta-analysis

et al. 2021

Self Cite

View full text Add to dashboard Cite

BackgroundAlthough subclinical hypothyroidism in pregnancy is one of the established risk factors for pre-eclampsia, the link between iodine deficiency, the main cause of hypothyroidism, and pre-eclampsia remains uncertain. We conducted a systematic review to determine the iodine nutrition status of pregnant women with and without pre-eclampsia and the risk of pre-eclampsia due to iodine deficiency.MethodsMEDLINE, EMBASE, Google Scholar, Scopus and Africa-Wide Information were searched up to 30th June 2020. Random-effect model meta-analysis was used to pool mean difference in urinary iodine concentration (UIC) between pre-eclamptic and normotensive controls and pool ORs and incidence rates of pre-eclampsia among women with UIC <150 µg/L.ResultsFive eligible studies were included in the meta-analysis. There was a significant difference in the pooled mean UIC of 254 pre-eclamptic women and 210 normotensive controls enrolled in three eligible case–control studies (mean UIC 164.4 µg/L (95% CI 45.1 to 283.6, p<0.01, I2 >50)). The overall proportions of pre-eclampsia among women with UIC <150 µg/L and UIC >150 µg/L in two cross-sectional studies were 203/214 and 67/247, respectively, with a pooled OR of 0.01 (95% CI 0 to 4.23, p=0.14, I2 >50) for pre-eclampsia among women with UIC >150 µg/L. The overall incidence of pre-eclampsia among women with UIC <150 µg/L and UIC >150 µg/L in two cohort studies was 6/1411 and 3/2478, respectively, with a pooled risk ratio of 2.85 (95% CI 0.42 to 20.05, p=0.09, I2 <25).ConclusionAlthough pre-eclamptic women seem to have lower UIC than normotensive pregnant women, the available data are insufficient to provide a conclusive answer on association of iodine deficiency with pre-eclampsia risk.PROSPERO registration numberCRD42018099427.

show abstract

“…Iodine deficiency is one of the major causes of thyroid dysfunction and affects approximately two billion people worldwide. It has recently been found that different groups of the population have mild to moderate iodine deficiency, especially children and pregnant women [10]. Some studies suggest that oxidative stress may be a contributing factor to PE and that iodine, as one of the most potent exogenous antioxidants, may reduce the risk of this disorder [11,12].…”

Section: Introductionmentioning

confidence: 99%

Urinary iodine as an important indicator for preeclampsia: a Polish perspective

Gajewska

Laskowska

Błażewicz

2021

Current Issues in Pharmacy and Medical Sciences

View full text Add to dashboard Cite

Preeclampsia (PE) is one of the leading causes of perinatal and maternal morbidity. Although subclinical hypothyroidism in pregnancy is one of the established risk factors for PE, the link between iodine deficiency and PE is not fully understood. The aim of our study was to assess urinary iodine concentration (UIC), serum thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4) levels in Polish women with PE (PE group, n=78) compared with healthy non-pregnant women (CNP group, n=30), and healthy pregnant women (CP group, n=46). The UIC was determined by inductively coupled plasma mass spectrometry (ICP-MS). Both the mean UIC of 144.6±36.4 μg/L in the CP group and the mean of 125.8±33.6 μg/L in the PE group, respectively, were lower compared to non-pregnant women (149.8±28.8 μg/L), and the difference between the PE and CNP groups was statistically significant. TSH values were the highest in the PE group, while the lowest average level was for the CNP group. The fT3 and fT4 values in the PE group were significantly lower compared to the CNP and CP groups. Despite iodine supplementation during pregnancy, the UIC was lower compared to non-pregnant women, while in women with PE it was at a significantly lower level. To reduce the incidence of possible health complications, proper iodine supplementation and monitoring of the UIC is recommended for pregnant women suffering from PE or at risk of developing PE.

show abstract

Iodine Deficiency in Pregnancy as a Predictor of Sub-clinical Hypothyroidism, Preeclampsia and Future Cardiovascular Disease

Cited by 4 publications

References 15 publications

Iodine deficiency in pregnancy along a concentration gradient is associated with increased severity of preeclampsia in rural Eastern Cape, South Africa

Iodine deficiency in pregnancy along a concentration gradient is associated with increased severity of preeclampsia in rural Eastern Cape, South Africa

Insufficient iodine nutrition status and the risk of pre-eclampsia: a systemic review and meta-analysis

Urinary iodine as an important indicator for preeclampsia: a Polish perspective

Contact Info

Product

Resources

About