Iodine concentration and content measured by dual-source computed tomography are correlated to thyroid hormone levels in euthyroid patients

Li, ZhengTeng; Zhai, Rui; Liu, Hongmei; Pan, Dongmei

doi:10.21203/rs.2.14576/v2

Cited by 1 publication

(2 citation statements)

References 5 publications

(6 reference statements)

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“…35 Interestingly, because of different attenuation coefficients of the same substance at different energy X-rays, dual-energy CT scanning technique not only easily distinguishes iodine from other different substances but also accurately and quantitatively calculates the IC in the region of interest. 17 Through DSCT scanning, our results unveiled lower levels of IC in plain CT and venous phase NIC in TC patients than those in patients with benign lesions. There is evidence suggesting that some thyroid follicular cells existing in nodular goiter, adenoma, and other benign lesions still show normal functions of iodine uptake; however, thyroid follicular cells are almost replaced by fibrotic connective tissues and cancer cells in papillary TC, leading to the loss of iodine uptake function.…”

Section: Discussionmentioning

confidence: 58%

“…16 The thyroid IC level measured by dual-energy CT shows utility for evaluating human iodine nutritional status and thyroid function, facilitating the diagnosis and management of thyroid diseases. 17 Notably, relative to conventional CT images, quantitative dual-energy CT parameters (such as IC) can efficiently diagnose small lymph node metastases in TC. 18 Given the distinct advantages, the clinical utility of DSCT in TC diagnosis is worth investigating.…”

Section: Introductionmentioning

confidence: 99%

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Application of dual‐source computed tomography in the diagnosis of thyroid cancer and evaluation of biological behaviors

Fang

et al. 2022

J of Clinical Ultrasound

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Objective Thyroid cancer (TC) is an extremely prevailing malignant endocrine tumor. Therefore, effective diagnostic tools are necessary. This study explored the application value of dual‐source computed tomography (DSCT) in TC diagnosis and biological behavior assessment. Methods This study retrospectively selected 68 TC patients and another 74 benign patients with thyroid adenoma, nodular goiter, or adenomatous hyperplasia. All patients were confirmed by pathological examination and underwent DSCT examination. The iodine concentration (IC) obtained from plain computed tomography (CT) scanning and normalized iodine concentration (NIC) in the arterial phase and venous phase were recorded. The positive expression rates of estrogen receptor alpha (ERα), estrogen receptors beta (ERβ), and Ki67 in pathological tissues were determined by immunohistochemistry, and their correlation with IC in plain CT was assessed by Pearson correlation analysis, respectively. The diagnostic values of IC in plain CT and venous phase NIC in TC patients were evaluated using the receiver operating characteristic curve. Results Malignant patients had lower IC in plain DSCT scanning, venous phase NIC, and ERβ, and higher ERα and Ki67 than benign patients. IC level in plain DSCT scanning was inversely‐correlated with ERα and Ki‐67 positive expression rates, but positively‐related to ERβ to different degrees. For the diagnosis of TC patients, the AUC of IC level in plain DSCT was 0.771, with a cut‐off value of 1.250 (97.06% sensitivity and 41.89% specificity), and the AUC of venous phase NIC was 0.738, with a cut‐off value of 0.825 (100% sensitivity and 43.24% specificity). Conclusion The IC level obtained from DSCT scanning could assist in the differential diagnosis of malignant and benign thyroid nodules and evaluation of biological behaviors.

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Section: Discussionmentioning

confidence: 58%