Iodine catalyzed oxidation of alcohols and aldehydes to carboxylic acids in water: a metal-free route to the synthesis of furandicarboxylic acid and terephthalic acid

Hazra, Susanta; Deb, Mayukh; Elias, Anil J.

doi:10.1039/c7gc02802d

Cited by 69 publications

(37 citation statements)

References 86 publications

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“…So far, the selective oxidation of alcohols to acids by carbon based metal‐free catalysts has seldom reported . Although, the I 2 catalyzed oxidation of alcohols to carboxylic acids can be achieved with NaOH as promoted . The 3 equiv.…”

Section: Resultsmentioning

confidence: 99%

Nitrogen and Phosphorus Co‐Doped Graphene‐Like Carbon Catalyzed Selective Oxidation of Alcohols

Yang

Cao²,

et al. 2019

Asian J Org Chem

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The nitrogen and phosphorus co-doped graphenelike carbon (NPG) is cost-effective fabricated by simple ballmilling and thermal treatment. The as-prepared NPG can be used as a metal-free catalyst for selective catalytic oxidation of aromatic alcohols to their corresponding acids by using TBHP and O 2 as the oxidant in water. It is observed that various aromatic alcohols bearing electron-donating/withdrawing groups can be oxidized to the corresponding acids in excellent yields. No dehalogenation and steric-hindrance effects are detected in this oxidation process. In addition, the NPG catalyst can be easily separated and efficiently reused seven times, showing good recyclability.[a] Prof.for 48 h. At the end of ball milling, oxygen and nitrogen functional groups are introduced by ball milling. The final material is further Soxhlet extracted using 1 M HCl solution to eliminate metallic impurities followed by using deionized water and ethanol washing four times and drying at 80°C in the oven in 8 h.

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Section: Resultsmentioning

confidence: 99%

Nitrogen and Phosphorus Co‐Doped Graphene‐Like Carbon Catalyzed Selective Oxidation of Alcohols

Yang

Cao²,

et al. 2019

Asian J Org Chem

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“…Cuminic acid (2) was prepared by the oxidation of cuminaldehyde (1) following a reported procedure [36]. Cuminaldehyde (10 mmol) in water was mixed with iodine and NaOH (10 mmol) and TBHP (20 mmol) as catalyst [36]. Yield 62%.…”

Section: Synthesis Of 4-isopropyl Benzoic Acid (Cuminic Acid) (2)mentioning

confidence: 99%

Essential Oil-Based Design and Development of Novel Anti-Candida Azoles Formulation

et al. 2020

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Candida is the most common fungal class, causing both superficial and invasive diseases in humans. Although Candida albicans is the most common cause of fungal infections in humans, C. auris is a new emergent serious pathogen causing complications similar to those of C. albicans. Both C. albicans and C. auris are associated with high mortality rates, mainly because of their multidrug-resistance patterns against most available antifungal drugs. Although several compounds were designed against C. albicans, very few or none were tested on C. auris. Therefore, it is urgent to develop novel effective antifungal drugs that can accommodate not only C. albicans, but also other Candida spp., particularly newly emergent one, including C. auris. Inspired by the significant broad-spectrum antifungal activities of the essential oil cuminaldehyde and the reported wide incorporation of azoles in the antifungal drugs, a series of compounds (UoST1-11) was designed and developed. The new compounds were designed to overcome the toxicity of the aldehyde group of cuminaldehyde and benefit from the antifungal selectivity of azoles. The new developed UoST compounds showed significant anti-Candida activities against both Candida species. The best candidate compound, UoST5, was further formulated into polymeric nanoparticles (NPs). The new formula, UoST5-NPs, showed similar activities to the nanoparticles-free drug, while providing only 25% release after 24 h, maintainng prolonged activity up to 48 h and affording no toxicity. In conclusion, new azole formulations with significantly enhanced activities against C. albicans and C. auris, while maintaining prolonged action and no toxicities at lower concentrations, were developed.

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“…Therefore, our hypervalent iodine compounds may become attractive 'green catalysts' in the ever-evolving fields of alcohol oxidations and other challenging oxidative processes. 30,31,[78][79][80][81]…”

Section: Introductionmentioning

confidence: 99%

Oxidation of secondary alcohols using solid-supported hypervalent iodine catalysts

Ballaschk

Kirsch

2019

Green Chem.

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Iodine catalyzed oxidation of alcohols and aldehydes to carboxylic acids in water: a metal-free route to the synthesis of furandicarboxylic acid and terephthalic acid

Abstract: Iodine(iii) catalyzed metal free method for oxidation of alcohols and aldehydes in water.

Cited by 69 publications

References 86 publications

Nitrogen and Phosphorus Co‐Doped Graphene‐Like Carbon Catalyzed Selective Oxidation of Alcohols

Nitrogen and Phosphorus Co‐Doped Graphene‐Like Carbon Catalyzed Selective Oxidation of Alcohols

Essential Oil-Based Design and Development of Novel Anti-Candida Azoles Formulation

Oxidation of secondary alcohols using solid-supported hypervalent iodine catalysts

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