Iodine-catalyzed Csp3-H functionalization of methylhetarenes: One-pot synthesis and cytotoxic evaluation of heteroarenyl-benzimidazoles and benzothiazole

Development of a Novel Benzimidazole-Based Probe and Portable Fluorimeter for the Detection of Cysteine in Human Urine

“…To the best of our knowledge, this is a first report on the synthesis of compound 3 . The reported synthetic procedures to obtain benzimidazole derivatives are different than the one employed here [ 39 , 40 ]. The previously reported methods used stringent reaction conditions, including dimethyl sulfoxide as a solvent, the temperature of 110 °C, and I 2 as a catalyst.…”

Recent synthetic efforts in the preparation of 2-(3,4)-alkenyl (aryl) quinoline molecules towards anti-kinetoplastid agents

“…Such condensations were possible using simple I 2 -DMSO oxidative system in open ask (Scheme 13). 94,95 These potential bioactive hybrids were prepared in high yields with good substrate scope and functional group tolerance.…”

Design, Synthesis, and Evaluation of Bis‐Benzothiazole Derivatives as DNA Minor Groove Binding Agents

“…13 A mixture of compound 4 (0.5 g, 1.8 mmol), substituted benzaldehyde (1.8 mmol), and sodium hydrogensulfite (0.37 g, 3.6 mmol) in methanol (40 mL) were heated to reflux for 8 h. After removal of the solvent under reduced pressure, the residue was purified by gel column chromatography (CHCl 3 : CH 3 OH = 30:1) to give the targets 5-14. 114.5, 121.2, 122.1, 124.3, 128.3, 128.9, 133.6, 134.0 Table 1 The antitumor activities of the targets (5)(6)(7)(8)(9)(10)(11)(12)(13)(14) The experiments were performed twice, and the average values were obtained from two independent experiments. 13 The antitumor properties of all these compounds were tested by the standard MTT assay technique.…”

“…Benzimidazole derivatives, which exhibited diverse biological properties such as anti-tubercular [6][7][8], antimalarial [9], anti-microbial [10], and anticancer [11][12][13] activities, have received considerable attention. However, most investigators focused on single benzimidazole derivatives, and only a few literatures related bisbenzothiazole derivatives as anticancer agents have reported so far to the best of our knowledge.…”

“…Heterocyclic compounds are ubiquitous and play a vital role in drugs discovery, and amongst them, benzimidazole, which contains benzene and a heterocyclic imidazole ring, occupies an important position in medicinal chemistry. Benzimidazole derivatives, which exhibited diverse biological properties such as anti‐tubercular , anti‐malarial , anti‐microbial , and anticancer activities, have received considerable attention. However, most investigators focused on single benzimidazole derivatives, and only a few literatures related bis‐benzothiazole derivatives as anticancer agents have reported so far to the best of our knowledge.…”