Iodine-125 Treatment for Thyrotoxicosis

Greig, W. R.; Smith, Johanna; Gillespie, F.C.; Thomson, John A.; McGirr, E. M.

doi:10.1016/s0140-6736(70)92014-3

Cited by 16 publications

(7 citation statements)

References 11 publications

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“…Determination of the volume of the thyroid gland is considered of value in the assessment of patients with thyrotoxicosis, especially in calculating the correct dosage of radioactive iodine (1)(2)(3)(4)(5)(6)(7)(8)(9). Moreover, if the normal range of thyroid volume is known, enlargement of the gland can be diagnosed, and repeated determinations of the volume of the gland might be of help in evaluating the adequacy of treatment A number of methods have been developed for the in uiuo determination of thyroid volume or weight.…”

Section: Indexing Words Ultrasonic Scanningmentioning

confidence: 99%

Determination of thyroid volume by ultrasonic scanning

Rasmussen

Hjorth

1974

J of Clinical Ultrasound

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A method for thyroid volume calculation based upon ultrasonic scanning is described. The accuracy of the method was estimated by comparing ultrasonically determined volumes with the volumes of surgically removed thyroid glands. The precision (i.e., reproducibility) was estimated by comparing the ultrasonic volumes determined by two separate investigators in a double blind fashion. The normal range of thyroid volume was evaluated in a group of volunteers. The accuracy was acceptable, but the precision was borderline and appears to be the limiting factor in the procedure. We concluded that at present this method offers no significant improvement over other methods currently in use. However, thyroid volume calculation based upon palpation of the gland cannot be standardized, and isotope scanning is a more comprehensive and expensive procedure. Several possibilities exist for improvement of the ultrasonic technique, and the procedure holds promise for the future. Indexing Words Ultrasonic ScanningDetermination of the volume of the thyroid gland is considered of value in the assessment of patients with thyrotoxicosis, especially in calculating the correct dosage of radioactive iodine (1)(2)(3)(4)(5)(6)(7)(8)(9). Moreover, if the normal range of thyroid volume is known, enlargement of the gland can be diagnosed, and repeated determinations of the volume of the gland might be of help in evaluating the adequacy of treatment A number of methods have been developed for the in uiuo determination of thyroid volume or weight. Judgment by palpation (SO) is subjective and inaccurate. Isotope scanning in one or two planes has been used, but these methods were also found to be inaccurate (1 1 , 12).

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Section: Indexing Words Ultrasonic Scanningmentioning

confidence: 99%

Determination of thyroid volume by ultrasonic scanning

Rasmussen

Hjorth

1974

J of Clinical Ultrasound

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“…Theoreticallypost-irradiationhypothyroidism should be negligible, but experience with this isotope has not been encouraging (McDougal et al, 1970). Certain clinical situations, e.g.…”

Section: Discussionmentioning

confidence: 99%

Radioactive iodine (131I) therapy for thyrotoxicosis at Groote Schuur Hospital over a 6-year period

Sagel

Epstein

Kalk

et al. 1972

Postgraduate Medical Journal

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“…After an average follow-up period of 25 months 87.5% were euthyroids, 10.4% hypothyroids and 2.1% were thyrotoxics in the middle dose group [22,23]. The middle and mixed dose groups showed the best results.…”

Section: Clinical Trials Of 1251 For Thyrotoxicosismentioning

confidence: 92%

“…Results of a typical case for a hyperthyroid follicle are shown in Figure 1 [6]. Gland mass was 50 g and colloidal volume 12.5% of the gland containing 23 Fig. Gland mass was 50 g and colloidal volume 12.5% of the gland containing 23 Fig.…”

Section: B Dosimetrymentioning

confidence: 99%

“…The results of these clinical trials reported from Glasgow [20][21][22][23][24]; New York, Amsterdam [25][26][27][28][29]; Tel Aviv [30][31][32][33] and Los Angeles [34] are briefly summarised in Table 2. The results of these clinical trials reported from Glasgow [20][21][22][23][24]; New York, Amsterdam [25][26][27][28][29]; Tel Aviv [30][31][32][33] and Los Angeles [34] are briefly summarised in Table 2.…”

Section: Clinical Trials Of 1251 For Thyrotoxicosismentioning

confidence: 99%

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Physical and radiobiological bases of the use of125I in the management of thyrotoxicosis

1976

Radiat Environ Biophys

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Increasing interest is recently shown in the use of 125I as an alternative isotope to 131I for the management of thyrotoxicosis based on the postulate that there is a relative sparing of the reproductive integrity of the thyroid follicular cell and a consequent possibility of smaller incidence of hypothyroidism after therapy. A review of the dosimetric, radiobiological anc clinical aspects of the use of 125I are presented here. For the same activity though 125I gives smaller mean gland dose than 131I, the dose computations at microscopic level have revealed that there is a preferential irradiation of the apical membrane compared to the nucleus of the follicular cell. The ratio of the dose to the apical membrane and that to the nucleus increases with the decrease of the percentage colloid mass of the gland. Radiobiological significance of this non-uniform dose distribution across a follicular cell, with 125I , is brought out using rat thyroid as the biological system. For the same mean gland dose the follicular cell survival is larger with 125I than with 131I. 24 H radioiodine uptake is reduced in case of 131I treatment whereas it is not affected with 125I. Pilot clinical trials using 125I for the management of thyrotoxicosis are underway in some centres. Preliminary results from centres using doses 3--4 times that of the conventional 131I dose are not very different from those with conventional 131I therapy. Centres that used doses same as or less than the conventional 131I doses, reported smaller incidence of hypothyroidism.

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Iodine-125 Treatment for Thyrotoxicosis

Cited by 16 publications

References 11 publications

Determination of thyroid volume by ultrasonic scanning

Determination of thyroid volume by ultrasonic scanning

Radioactive iodine (131I) therapy for thyrotoxicosis at Groote Schuur Hospital over a 6-year period

Physical and radiobiological bases of the use of125I in the management of thyrotoxicosis

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