Iodine-125 seed implantation for synchronous pancreatic metastases from hepatocellular carcinoma

Abstract

Rationale:The image-guided iodine-125 seed implantation has been widely used for a variety of tumors, including prostatic cancer, pulmonary cancer, hepatocellular carcinoma and pancreatic cancer. However, the clinical value of iodine-125 seed implantation for the treatment of pancreatic metastasis from hepatocellular carcinoma has not been reported. We presented the first case with ultrasound-guided iodine-125 seed implantation for this disease.Patient concerns:We presented the case of a 48-year-old man patient with primary hepatocellular carcinoma and pancreatic metastasis who was managed with ultrasound-guided iodine-125 seeds implantation.Diagnoses:She was diagnosed with synchronous pancreatic metastases from hepatocellular carcinoma.Interventions:Puncture biopsy and ultrasound-guided iodine-125 seeds implantation.Outcomes:The hepatic and pancreatic tumors were obviously reduced after 15 months. Moreover, the liver function test was mildly abnormal in glutamic-oxalacetic transaminase and glutamic-pyruvic transaminase.Lessons:The image-guided iodine-125 seeds implantation was an important therapeutic approache to unresectable hepatocellular carcinoma with pancreatic metastasis. However, more related cases should be reported for further evaluating the value of the way.

RETRACTED: Clinical Research on Systemic Chemotherapy Combined With Bronchoscopic Seed Implantation in the Treatment of Advanced Lung Cancer

“…The constant exposure of radiation results in a significant decrease of tumor re-proliferation, while that in a low-dosage can inhibit mitosis of tumor cells and block cells in the G2 phase. 10 Hence, 125 I radiotherapy can maximally inactivating the tumor cells, ultimately attaining the treatment purpose.…”

A novel combination of percutaneous stenting with iodine-125 seed implantation and chemotherapy for the treatment of pancreatic head cancer with obstructive jaundice

“…Meanwhile, the normal tissues around the tumor may be exposed to a sharp drop in the amount of radiation due to the low radioactive activity of particles, thus reducing the damage to the surrounding small intestine, blood vessels, and other pipelines. This low-dose, long-lasting radioactive source is more likely to damage tumor cells and inhibit tumor growth (34). Patients with pancreatic cancer often have intractable acute pain in the lower back or abdomen caused by tumor compression or invasion of the abdominal plexus, which can be prevented through the application of radioactive particles treatment, thus playing a better analgesic effect.…”

Hepatocellular carcinoma with pancreatic mass as the first symptom: a case report and literature review

“…Extrahepatic metastasis of primary liver cancer is most common in hematogenous metastasis, mostly to the lungs, bones, distant lymph nodes, and brain. 1 The incidence of extrahepatic lung metastasis in HCC is nearly 30% (7), but the occurrence of pancreatic metastasis in HCC is very low, with only a few reported in case reports (8)(9)(10)(11), the first of which was by Lowe et al (8) in 1997. Research by Cheng (12) shows that the overall survival of patients with advanced liver cancer who were not given intervention was only 7.9 months, while the overall survival of patients taking sorafenib could be extended to 10.7 months.…”