Inwardly rectifying potassium channel 5.1: Structure, function, and possible roles in diseases

Zhang, Junhui; Han, Jing; Li, Lingfei; Zhang, Qiong; Feng, Yang; Jiang, Yao‐Guang; Deng, Fang; Zhang, Yuping; Wu, Qinan; Chen, Bing; Hu, Jiongyu

doi:10.1016/j.gendis.2020.03.006

Cited by 12 publications

(8 citation statements)

References 63 publications

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“…GABRD is widely reported to be closely associated with colon cancer ( Niu et al, 2020 ; Wu et al, 2020 ). KCNJ15 has been closely related to potassium channels and identified as a molecular marker by investigators in ccRCC ( Liu et al, 2019 ; Zhang J. et al, 2021 ). Furthermore, we also focused on exploring KCNJ16, which was significant in both diagnostic and prognostic signatures.…”

Section: Discussionmentioning

confidence: 99%

The Ion Channel-Related Gene Signatures Correlated With Diagnosis, Prognosis, and Individualized Treatment in Patients With Clear Cell Renal Cell Carcinoma

et al. 2022

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Background: Early detection and precise prognostic evaluation of clear cell renal cell carcinoma (ccRCC) are crucial for patient life expectancy. Ion channel-related genes (ICRGs) are of great diagnostic and prognostic value as components that maintain the normal structure of the kidney. Therefore, we systematically explored the diagnostic, prognostic, and therapeutic value of ICRGs in ccRCC using the multi-database.Methods: RNA transcriptome profiles and clinical data of ccRCC patients were extracted and integrated from public databases including The Cancer Genome Atlas, ICGC, GEO, and E-MTAB databases. Ion channel-related genes were obtained from the literature collection. The diagnostic signature was performed using the LASSO and SVM-REF analyses. Meanwhile, the prognostic signature was conducted using the LASSO analyses. Molecular subtyping was performed using the ConsensusClusterPlus and the corresponding therapeutic targets were evaluated using the pRRophetic package. In addition, a prognostic nomogram was constructed based on the results of cox regression analyses.Results: We successfully constructed diagnostic signatures for five ICRGs and prognostic signatures for 10 ICRGs with AUC values greater than 0.7, showing good predictive performance. Based on the median risk score, we found that high-risk patients had a significantly worse prognosis. We also divided ccRCC patients into two clusters according to prognostic ICRGs, and there was a significant survival outcome between the two clusters and different sensitivity to diverse clinical therapeutic strategies. Meanwhile, we constructed a nomogram based on clinical molecules and signatures, and its predictive efficacy was better than the signature or the present tumor-node-metastasis staging system.Conclusion: In this study, we established useful signatures for early detection, prognosis evaluation, and individualized treatment for ccRCC. Moreover, KCNJ16 deserves to be explored comprehensively in the future.

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Section: Discussionmentioning

confidence: 99%

The Ion Channel-Related Gene Signatures Correlated With Diagnosis, Prognosis, and Individualized Treatment in Patients With Clear Cell Renal Cell Carcinoma

et al. 2022

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“…The inward rectifier potassium channel family is a class of non-voltage-gated K + channels, and current data suggest that there are seven subfamilies of Kir channels(Kir1.1 to Kir7.1), which can be usually divided into four categories according to function: classical Kir channels(Kir2.X), G-protein-activated Kir channels(Kir3.X), ATP-sensitive potassium channels(Kir6.X), and K + transport channels(Kir1.X, Kir4.X, Kir5.X, and Kir7.X) ( 35 , 36 ). Kir is widely distributed in various tissues of the human body and has a variety of physiological functions, playing a pivotal role in maintaining resting potential, controlling cell excitability, and regulating cell volume, and its activity is controlled by a variety of mediators, such as binding proteins, phospholipids, and ions ( 37 ).…”

Section: Relationship Between Potassium Channel and Tumormentioning

confidence: 99%

Potassium channels: Novel targets for tumor diagnosis and chemoresistance

Tian

Zhao

et al. 2023

Front. Oncol.

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In recent years, the role of potassium channels in tumors has been intensively studied. Potassium channel proteins are widely involved in various physiological and pathological processes of cells. The expression and dysfunction of potassium channels are closely related to tumor progression. Potassium channel blockers or activators present antitumor effects by directly inhibiting tumor growth or enhancing the potency of classical antitumor agents in combination therapy. This article reviews the mechanisms by which potassium channels contribute to tumor development in various tumors in recent years, introduces the potential of potassium channels as diagnostic targets and therapeutic means for tumors, and provides further ideas for the proper individualized treatment of tumors.

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“…This review introduces the inward-rectifying potassium channel Kir5.1 from three aspects: the main physiological characteristics, the pathological processes involved and the connection with various human diseases. Overall, this review broadly summarizes the functions of Kir5.1 reported in existing studies, and provides new ideas for future research exploring the diverse biological functions of Kir5.1 and its possible significance in human diseases (Zhang et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Diverse functions of the inward-rectifying potassium channel Kir5.1 and its relationship with human diseases

Zhang

Guo²

2023

Front. Physiol.

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The inward-rectifying potassium channel subunit Kir5.1, encoded by Kcnj16, can form functional heteromeric channels (Kir4.1/5.1 and Kir4.2/5.1) with Kir4.1 (encoded by Kcnj10) or Kir4.2 (encoded by Kcnj15). It is expressed in the kidneys, pancreas, thyroid, brain, and other organs. Although Kir5.1 cannot form functional homomeric channels in most cases, an increasing number of studies in recent years have found that the functions of this subunit should not be underestimated. Kir5.1 can confer intracellular pH sensitivity to Kir4.1/5.1 channels, which can act as extracellular potassium sensors in the renal distal convoluted tubule segment. This segment plays an important role in maintaining potassium and acid-base balances. This review summarizes the various pathophysiological processes involved in Kir5.1 and the expression changes of Kir5.1 as a differentially expressed gene in various cancers, as well as describing several other disease phenotypes caused by Kir5.1 dysfunction.

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Inwardly rectifying potassium channel 5.1: Structure, function, and possible roles in diseases

Cited by 12 publications

References 63 publications

The Ion Channel-Related Gene Signatures Correlated With Diagnosis, Prognosis, and Individualized Treatment in Patients With Clear Cell Renal Cell Carcinoma

The Ion Channel-Related Gene Signatures Correlated With Diagnosis, Prognosis, and Individualized Treatment in Patients With Clear Cell Renal Cell Carcinoma

Potassium channels: Novel targets for tumor diagnosis and chemoresistance

Diverse functions of the inward-rectifying potassium channel Kir5.1 and its relationship with human diseases

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