Inward rectifying potassium channels facilitate cell-to-cell communication in hamster retractor muscle feed arteries

Jantzi, Micaela C; Brett, Suzanne E.; Jackson, William F.; Corteling, Randolph; Vigmond, Edward J.; Welsh, Donald G.

doi:10.1152/ajpheart.00217.2006

Cited by 87 publications

(97 citation statements)

References 36 publications

(68 reference statements)

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“…Using a range of in vitro methods and computational modeling, it was shown that the negative-slope conductance of K IR channels during hyperpolarization of VSMCs would augment the initial hyperpolarization as it conducts through VSMCs along the vascular wall. 54 Thus, this was the first concrete molecular evidence of a regenerative mechanism.…”

Section: How Vascular Conducted Responses Are Typically Measuredmentioning

confidence: 83%

The Vascular Conducted Response in Cerebral Blood Flow Regulation

Jensen¹,

Holstein‐Rathlou

2013

J Cereb Blood Flow Metab

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Despite recent advances in our understanding of the molecular and cellular mechanisms behind vascular conducted responses (VCRs) in systemic arterioles, we still know very little about their potential physiological and pathophysiological role in brain penetrating arterioles controlling blood flow to the deeper areas of the brain. The scope of the present review is to present an overview of the conceptual, mechanistic, and physiological role of VCRs in resistance vessels, and to discuss in detail the recent advances in our knowledge of VCRs in brain arterioles controlling cerebral blood flow. We provide a schematic view of the ion channels and intercellular communication pathways necessary for conduction of an electrical and mechanical response in the arteriolar wall, and discuss the local signaling mechanisms and cellular pathway involved in the responses to different local stimuli and in different vascular beds. Physiological modulation of VCRs, which is a rather new finding in this field, is discussed in the light of changes in plasma membrane ion channel conductance as a function of health status or disease. Finally, we discuss the possible role of VCRs in cerebrovascular function and disease as well as suggest future directions for studying VCRs in the cerebral circulation.

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Section: How Vascular Conducted Responses Are Typically Measuredmentioning

confidence: 83%

The Vascular Conducted Response in Cerebral Blood Flow Regulation

Jensen¹,

Holstein‐Rathlou

2013

J Cereb Blood Flow Metab

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“…Candidate ion channels involved in this process currently favor an important role for inwardly rectifying K + (KIR) channels. 63,70,71 However, this does not appear to be universal, as Ba 2+ alone (to inhibit KIR channels) has no effect on spreading dilatation to either ACh or levcromakalim in rat mesenteric arteries, 62 but the Na + /K + -ATPase, which we know can also be activated by modest increases in extracellular [K + ], 5 may play an as yet to be determined role. This raises the possibility that the release of K + from vascular cells during hyperpolarization may act as an amplification mechanism, with a distinct parallel to its action as an EDHF.…”

Section: Spreading Dilatation Following Luminal Perfusion Of Agonistsmentioning

confidence: 94%

Coordination of Vasomotor Responses by the Endothelium

Dora

2010

Circ J

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“…It is known from the study of cultured cells that this class of channels is responsible for the stability of membrane potential and sensitivity to the external signals (Suzuki et al, 2003;Wischmeyer et al, 2000;Yasuda et al, 2003). Recently Jantzi et al reported that the kir channel (Kir2.2) facilitates cell-to-cell communication that propagates the contraction signal in hamster retractor muscle feed artery (Jantzi et al, 2006). In zebrafish, the Kir7.1 gene is expressed in melanophores , suggesting that the channel controls the interaction of the melanophores.…”

Section: Mutants That Affect the Pigment Pattern But Not The Developmentioning

confidence: 99%

How animals get their skin patterns: fish pigment pattern as a live Turing wave

Kondo¹,

Iwashita²,

Yamaguchi³

2009

Int. J. Dev. Biol.

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It is more than fifty years since Alan Turing first presented the reaction-diffusion (RD) model, to account for the mechanism of biological pattern formation. In the paper entitled "The chemical basis of morphogenesis", Turing concluded that spatial patterns autonomously made in the embryo are generated as the stationary wave of the chemical (cellular) reactions. Although this novel idea was paid little attention by experimental biologists, recent experimental data are suggesting that the RD mechanism really functions in some of the course of animal development. Among the phenomena in which involvement of the RD mechanism is suspected, the striped pigment pattern of zebrafish has been highlighted as an ideal model system for the following reasons: the stationary wave made by the RD mechanism stays alive and can be observed only in the fish skin; and in zebrafish, we can utilize genomic information and molecular genetic techniques to clarify the molecular basis of pattern formation. In this review, we summarize recent progresses in the study of zebrafish pigment pattern formation that is uncovering how the RD wave is made and maintained in the skin.

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Inward rectifying potassium channels facilitate cell-to-cell communication in hamster retractor muscle feed arteries

Abstract: Inward rectifying potassium channels facilitate cell-to-cell communication in hamster retractor muscle feed arteries.

Cited by 87 publications

References 36 publications

The Vascular Conducted Response in Cerebral Blood Flow Regulation

The Vascular Conducted Response in Cerebral Blood Flow Regulation

Coordination of Vasomotor Responses by the Endothelium

How animals get their skin patterns: fish pigment pattern as a live Turing wave

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