Involvement of α1B-adrenoceptors in the anti-immobility effect of imipramine in the tail suspension test

Ribeiro, Carlos Alberto S.; Pupo, André S.

doi:10.1016/j.ejphar.2015.01.010

Cited by 10 publications

(6 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antagonism of the α 1 ‐adrenoceptor blocks the anti‐immobility action of imipramine in the tail suspension test [14]. To examine whether the α 1 ‐adrenoceptor is involved in the anti‐immobility action of NYT, we analyzed the effect of prazosin (an α 1 ‐adrenoceptor antagonist) on the anti‐immobility effect of NYT.…”

Section: Resultsmentioning

confidence: 99%

“…Given that imipramine increases extracellular levels of 5-HT and NE [18], NYT may exert its anti-immobility effect by affecting serotonergic and noradrenergic systems. α 1 -Adrenoceptor antagonism diminishes the anti-immobility effect of NYT Antagonism of the α 1 -adrenoceptor blocks the anti-immobility action of imipramine in the tail suspension test [14]. To examine whether the α 1 -adrenoceptor is involved in the antiimmobility action of NYT, we analyzed the effect of prazosin (an α 1 -adrenoceptor antagonist) on the anti-immobility effect of NYT.…”

Section: Nyt Attenuates Immobility In the Tail Suspension Testmentioning

confidence: 99%

See 1 more Smart Citation

Ninjinyoeito exerts an antidepressant‐like effect by enhancing the central noradrenergic system

Tsutsumi

Watanabe

Hatae

et al. 2022

Traditional & Kampo Medicine

View full text Add to dashboard Cite

Aim: Ninjinyoeito (NYT) is a Kampo medicine prescribed for patients with decreased mental and physical energy. Clinical studies demonstrate that NYT ameliorates depressive symptoms in patients with various diseases. However, the underlying therapeutic mechanisms of action remain unclear. The monoaminergic system has been implicated in the neuropathology of depression. Using immobility in the tail suspension test to evaluate depression-like behavior, we aimed to examine the effects of NYT and the involvement of the α 1 -adrenoceptor and serotonin (5-HT) 1A receptor in its mechanism of action. Methods: Immobility in the tail suspension test was used as an index of depression-like behavior. NYT (1,000 or 2,000 mg/kg/ day, once a day for seven days) was orally administered to mice. Prazosin and WAY-100635 were administered 30 min and 1 h before the test, respectively. Norepinephrine (NE) and 5-HT levels in the frontal cortex and amygdala were analyzed using a high-performance liquid chromatography (HPLC) electrochemical detector. Results: NYT (2000 mg/kg/day) shortened the immobility time. Prazosin and WAY-100635 blocked the NYT-mediated reduction in immobility time. NYT increased NE levels, but not 5-HT levels, in the amygdala. Conclusion: NYT reduced immobility time in the tail suspension test, likely by increasing NE levels. The increased NE levels may activate the α 1 -adrenoceptor, thereby ameliorating the depression-like behavior. NYT may therefore improve depressive symptoms in patients by enhancing the noradrenergic system.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Nyt Attenuates Immobility In the Tail Suspension Testmentioning

confidence: 99%

Ninjinyoeito exerts an antidepressant‐like effect by enhancing the central noradrenergic system

Tsutsumi

Watanabe

Hatae

et al. 2022

Traditional & Kampo Medicine

View full text Add to dashboard Cite

show abstract

“…In addition, there is an article stating that prazosin alone is depressing, but when used with imipramine, it increases the antidepressant effect of imipramine [37]. Also, contrary to these, there are also articles stating that it can increase depression in those taking electroconvulsive therapy or antidepressant therapy [38,39,40,41].…”

Section: Discussionmentioning

confidence: 99%

Effects of Terazosin, Silodosin and Alfuzosin on Depression and Anxiety in Mice

Tanyeri¹,

Büyükokuroğlu

Tanyeri

et al. 2021

JPRI

View full text Add to dashboard Cite

Aims: Benign prostatic hyperplasia (BPH) is common urological disease, is characterized by lower urinary tract syndrome, usually associated with sexual dysfunctions. The aim of present study is to investigate the effects of terazosin, silodosin and alfuzosin which are the main treatment options for BPH on depression and anxiety to understand whether these drugs may be effective in BPH caused mood disorders. Study Design: All the drugs were given intraperitoneally (i.p.) in a volume of 0.1 ml per 10 g body weight of mice. Drugs were given 30 min before the experiment. We investigated the effects of terazosin, silodosin and alfuzosin on depression and anxiety, in mice. Place and Duration of Study: Sample: Department of Pharmacology and Department of Urology, Sakarya University, Animal Research Center, between June 2019 and September 2020. Methodology: Here, we examined the effects of terazosin (0.5, 1, 2 mg/kg), silodosin silodosin (1, 3, 10 mg/kg) and alfuzosin (3, 6 and 9 mg/kg) on depression and anxiety by using forced swimming test and elevated plus maze test, respectively, in mice (n:96). Additionally, the locomotor activity was evaluated by open field test. Results: All doses of terazosin, alfuzosin and silodosin significantly increased immobility time, compared to saline group. Silodosin and alfuzosin prolonged the time spent in open arms but terazosin decreased the time spent in open arms compared to saline group. Terazosin, silodosin (1 and 3 mg/kg) and alfuzosin (3 and 6 mg/kg) did not have any effect on the number of entries into the open arms while silodosin (10 mg/kg) and alfuzosin (9 mg/kg) increased the number of entries into open arms. Conclusion: We found that silodosin and alfuzosin had antidepressant and anxiolytic-like effects, while terazosin had depressant and anxiogenic effects. Patients with BPH who need antidepressant and anxiolytic treatment can be treated with a single drug instead of multiple medications.

show abstract

“…It should also be noted that this compound did not affect diastolic blood pressure. Furthermore, there is evidence that the antagonism of α 1A - and α 1D -adrenoceptors results in antidepressant-like effects in mice [ 56 ]. Nevertheless, more experiments are needed to clarify this issue.…”

Section: Discussionmentioning

confidence: 99%

Antidepressant-like activity and safety profile evaluation of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione derivatives as 5-HT1A receptor partial agonists

et al. 2020

View full text Add to dashboard Cite

Current antidepressant therapy has several disadvantages related to the properties of antidepressants. Considering their unfavourable features, the process of searching for new antidepressant drugs with better safety and tolerability requires consistent efforts and many complementary studies. Serotonin 5-HT 1A receptor is considered as an interesting target of antidepressant therapy. In the present study, the intrinsic activity at different signaling pathways coupled to serotonin 5-HT 1A receptor, antidepressant-like and pharmacokinetic properties, and the safety profile of two novel imidazopurine-2,4-dione derivatives, namely compounds AZ-853 (8-(4-(4-(2-fluorophenyl)piperazin-1-yl)butyl)-1,3-dimethyl-1H-imidazo [2,1-f]purine-2,4(3H,8H)-dione) and AZ-861 (1,3-dimethyl-8-(4-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)butyl)-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione), were studied in animal models through in vitro and in vivo experiments. We demonstrated that AZ-853 and AZ-861, which structurally differ by one substituent and its placement in the phenyl ring, showed varied functional, pharmacological, and pharmacokinetic properties as well as side effect profiles. AZ-861 exhibited stronger agonistic action in all functional assays. After acute and repeated administration in mice, both compounds showed antidepressant-like activity in the forced swim test, which was partially mediated by 5-HT 1A receptor activation. AZ-853 showed a more potent antidepressant-like effect, presumably due to its better penetration into brain structures. Both compounds did not show anticholinergic properties, but after repeated administration, they induced weak sedation and lipid metabolism disturbances without affecting serum glucose level. The stronger α 1-adrenolytic effect of AZ-853 is responsible for decreased systolic blood pressure, and in contrast to AZ-861, AZ-853 induced weight gain in mice. The interesting comparative pharmacological profiles of AZ

show abstract

Involvement of α1B-adrenoceptors in the anti-immobility effect of imipramine in the tail suspension test

Cited by 10 publications

References 22 publications

Ninjinyoeito exerts an antidepressant‐like effect by enhancing the central noradrenergic system

Ninjinyoeito exerts an antidepressant‐like effect by enhancing the central noradrenergic system

Effects of Terazosin, Silodosin and Alfuzosin on Depression and Anxiety in Mice

Antidepressant-like activity and safety profile evaluation of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione derivatives as 5-HT1A receptor partial agonists

Contact Info

Product

Resources

About