Involvement of vanilloid receptor VR1 and prostanoids in the acid-induced writhing responses of mice

Ikeda, Yuri; Ueno, Akinori; Naraba, Hiroaki; Oh‐ishi, Sachiko

doi:10.1016/s0024-3205(01)01374-1

Cited by 250 publications

(156 citation statements)

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“…B, C, Chronic inflammatory hyperalgesia elicited by intrapaw injection of CFA was impaired in mutant (PKR1 Ϫ/Ϫ ) mice (B, paw immersion in significant within the noxious temperature range from 46 to 50°C, the operating range of C-polymodal nociceptors and the vanilloid channel TRPV1 (Le Bars et al, 2001;Tominaga and Tominaga, 2005). The impaired writhing response to intraperitoneal acetic acid in pkr1-null mice closely resembles that observed after pretreatment of wild-type mice with TRPV1 antagonists (Ikeda et al, 2001;Rigoni et al, 2003). Positive co-operation between PKRs and TRPV1 activation is also supported by the findings that Bv8 sensitizes primary afferent nociceptors to capsaicin and dramatically increases capsaicin-evoked specific currents in DRG neurons (Vellani et al, 2006).…”

Section: Discussionmentioning

confidence: 74%

Impaired Nociception and Inflammatory Pain Sensation in Mice Lacking the Prokineticin Receptor PKR1: Focus on Interaction between PKR1 and the Capsaicin Receptor TRPV1 in Pain Behavior

Negri

Lattanzi

Giannini

et al. 2006

Journal of Neuroscience

124

120

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Bv8, prokineticin-1 or EG-VEGF (endocrine gland-derived vascular endothelial growth factor), and prokineticin-2, are naturally occurring peptide agonists of two G-protein-coupled receptors (GPCRs), prokineticin receptor 1 (PKR1) and PKR2. PKRs are expressed in neurons in the CNS and peripheral nervous system and many dorsal root ganglion (DRG) cells expressing PKRs also express transient receptor potential vanilloid receptor-1 (TRPV1). Mice lacking the pkr1 gene were generated to explore the role of the PKR1 receptor in nociceptive signaling and in nociceptor sensitization. When compared with wild-type littermates, mice lacking the pkr1 gene showed impaired responsiveness to noxious heat, mechanical stimuli, capsaicin, and protons. In wild-type mice, activation of PKRs by the PKR agonist Bv8 caused hyperalgesia and sensitized to the actions of capsaicin. pkr1-null mice exhibited impaired responses to Bv8 but showed normal hyperalgesic responses to bradykinin and PGE2 (prostaglandin E2). Conversely, trpv1-null mice showed a reduced pronociceptive response to Bv8. Additionally, pkr1-null mice showed diminished thermal hyperalgesia after acute inflammation elicited by mustard oil and reduced pain behavior after chronic inflammation produced by complete Freund's adjuvant. The number of neurons that responded with a [Ca 2ϩ ] i increase to Bv8 exposure was five times lower in pkr1-null DRG cultures than in wild-type cultures. Furthermore, Bv8-responsive neurons from pkr1-null mice showed a significant reduction in the [Ca 2ϩ ] i response to capsaicin. These findings indicate a modulatory role of PKR1 in acute nociception and inflammatory pain and disclose a pharmacological interaction between PKR1 and TRPV1 in nociceptor activation and sensitization.

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Section: Discussionmentioning

confidence: 74%

Impaired Nociception and Inflammatory Pain Sensation in Mice Lacking the Prokineticin Receptor PKR1: Focus on Interaction between PKR1 and the Capsaicin Receptor TRPV1 in Pain Behavior

Negri

Lattanzi

Giannini

et al. 2006

Journal of Neuroscience

124

120

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“…In the abdominal constriction assay, acetic acid acts indirectly causing the release of nociceptive endogenous mediators, such as bradykinin, serotonin (5-HT), histamine, sympathomimetic amines, prostaglandins (PG), and pro-inflammatory cytokines (Ribeiro et al, 2000;Ikeda et al, 2001). Acetic acid can also directly activate non-selective cation channels located at primary afferent pathways (Julius & Basbaum, 2001).…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive and anti-inflammatory effects of Caesalpinia pyramidalis in rodents

Santos¹,

Passos²,

Andrade³

et al. 2011

Rev. bras. farmacogn.

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Caesalpinia pyramidalis Tul., Fabaceae, is a plant with an antiinflammatory activity that is used in folk medicine. To evaluate the mechanism of action of this plant, studies were performed on its antinociceptive and antiinflammatory properties using an ethanol extract (EE) made from the inner bark. Oral treatment of mice with the EE (100, 200, and 400 mg/kg) decreased their acetic acid-induced abdominal writhes (p<0.001) and their formalin-induced paw licking in both the first and second phases (p<0.001). This treatment increased the reaction time of mice on the hot-plate test (400 mg/kg, p<0.05); however, it did not alter their performance on the Rotarod performance test. The carrageenan-induced paw edema in the rats and the leukocyte migration into the peritoneal cavity of the mice were also reduced by the EE given at a dose of 400 mg/kg (p<0.05). In addition, the EE (100-400 mg/kg, v.o.) did not alter the arterial pressure of non-anesthetized rats. In conclusion, the EE of C. pyramidalis shows antinociceptive and anti-inflammatory activities in rodents, supporting the usage of this plant to treat various inflammatory diseases for which it has traditionally been used.

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“…This test is a non specific model of evaluating analgesia used to elucidate peripheral activity of tested compounds (Sánchez-Mateo et al, 2006). The nociceptive mechanism of this test involves prostaglandin biosynthesis via cyclooxygenase from arachidonic acid (Ikeda et al, 2001;Franzotti et al, 2002). Results of the present study showed that both doses of C. platythyrsa used produced significant analgesic effect which might be due to inhibition of the cyclooxygenase or arachidonic acid metabolite.…”

Section: Discussionmentioning

confidence: 62%

The effect of Cordia platythyrsa on various experimental models of pain and carrageenan induced inflammation

Nkeh-Chungag

Ndebia²,

Mbafor³

et al. 2014

Afr. J. Biotechnol.

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Only one study has reported on the medicinal properties of Cordia platythyrsa (C. platythyrsa) though it is used in African traditional medicine for treatment of fever and pain. The current study aimed at investigating the analgesic and anti-inflammatory properties of C. platythyrsa using various animal models: writhing test, tail flick, thermal hyperalgesia, mechanically induced-pain, formalin-induced pain and carrageenan-induced inflammation tests. Like aspirin, the two doses of plant extracts used inhibited acetic acid-induced pain though these effects were weaker than the effects of morphine. Although, the plant extract significantly (p<0.01) inhibited thermal pain, its effects were less significant compared to morphine. Celecoxib (10 mg/kg) and plant extract (100 mg/kg) significantly inhibited thermal hyperalgesia compared to indomethacin. On the other hand, both doses of plant extract significantly increased mechanical pain thresholds 30 and 90 min post treatment. The plant extract (150 mg/kg) inhibited both the neurogenic and inflammatory pain phases of formalin-induced pain as well as carrageenan-induced inflammation. This study is the first to show that C. platythyrsa has analgesic and anti-inflammatory properties.

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Involvement of vanilloid receptor VR1 and prostanoids in the acid-induced writhing responses of mice

Cited by 250 publications

References 0 publications

Impaired Nociception and Inflammatory Pain Sensation in Mice Lacking the Prokineticin Receptor PKR1: Focus on Interaction between PKR1 and the Capsaicin Receptor TRPV1 in Pain Behavior

Impaired Nociception and Inflammatory Pain Sensation in Mice Lacking the Prokineticin Receptor PKR1: Focus on Interaction between PKR1 and the Capsaicin Receptor TRPV1 in Pain Behavior

Antinociceptive and anti-inflammatory effects of Caesalpinia pyramidalis in rodents

The effect of Cordia platythyrsa on various experimental models of pain and carrageenan induced inflammation

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