Abstract:The rapidly inactivating potassium current (I A ) is important in controlling neuronal action potentials. Altered I A function and K + channel expression have been found in epilepsy, and activation of the transient receptor potential vanilloid 4 (TRPV4) channel is involved in epilepsy pathogenesis. This study examined whether TRPV4 affects Kv4.2 and K + channel interacting protein (KCHIP) expression and I A changes following pilocarpine-induced status epilepticus (PISE) in mice. Herein, hippocampal protein lev… Show more
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