Involvement of transient receptor potential vanilloid 2 in intra‐oral incisional pain

Urata, Kentaro; Shinoda, Masamichi; Ikutame, Daisuke; Iinuma, Toshimitsu; Iwata, Koichi

doi:10.1111/odi.12853

Cited by 7 publications

(9 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The MHWTs were measured up to 60 min before HC067047 administration and every 30 min after its administration on day 3 following IONI as described above. The administered tranilast and HC067047 doses were based on previous reports [14,44].…”

Section: Drug Administrationmentioning

confidence: 99%

“…TRPV2 as a member of the TRP channel family is a calcium-permeable channel and mostly expressed in medium-to large-sized sensory neurons with Aδ fibers sensitive to mechanical and heat (above 52 • C) stimuli [12,13]. In our previous study, increased TRPV2 expression in trigeminal ganglion (TG) neurons innervating the orofacial traumatized regions caused trauma-induced mechanical hypersensitivity [14]. Moreover, calcium influx into nociceptive neurons leads to the activation of neuronal calcium/calmodulin-dependent kinase II (CaMKII), resulting in neuropathic pain due to hyperexcitability of nociceptive neurons [15].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Increase in IGF-1 Expression in the Injured Infraorbital Nerve and Possible Implications for Orofacial Neuropathic Pain

Sugawara

Shinoda

Hayashi

et al. 2019

IJMS

Self Cite

View full text Add to dashboard Cite

Insulin-like growth factor-1 (IGF-1) is upregulated in the injured peripheral nerve bundle and controls nociceptive neuronal excitability associated with peripheral nerve injury. Here, we examined the involvement of IGF-1 signaling in orofacial neuropathic pain following infraorbital nerve injury (IONI) in rats. IONI promoted macrophage accumulation in the injured ION, as well as in the ipsilateral trigeminal ganglion (TG), and induced mechanical allodynia of the whisker pad skin together with the enhancement of neuronal activities in the subnucleus caudalis of the spinal trigeminal nucleus and in the upper cervical spinal cord. The levels of IGF-1 released by infiltrating macrophages into the injured ION and the TG were significantly increased. The IONI-induced the number of transient receptor potential vanilloid (TRPV) subfamily type 4 (TRPV4) upregulation in TRPV subfamily type 2 (TRPV2)-positive small-sized, and medium-sized TG neurons were inhibited by peripheral TRPV2 antagonism. Furthermore, the IONI-induced mechanical allodynia was suppressed by TRPV4 antagonism in the whisker pad skin. These results suggest that IGF-1 released by macrophages accumulating in the injured ION binds to TRPV2, which increases TRPV4 expression in TG neurons innervating the whisker pad skin, ultimately resulting in mechanical allodynia of the whisker pad skin.

show abstract

Section: Drug Administrationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Increase in IGF-1 Expression in the Injured Infraorbital Nerve and Possible Implications for Orofacial Neuropathic Pain

Sugawara

Shinoda

Hayashi

et al. 2019

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…Likewise, oromucosal induce of capsaicin -which activates TRPV1 -or menthol -which can activate both TRPM8 and TRPA1 [106] -induce release of CGRP [107]. Lastly, immunohistochemistry studies and PCR showed presence of TRPV2, TRPM3, TRPC1, TRPC3, and TRPC4 in trigeminal ganglionic neurons of lab animals [108][109][110][111][112].…”

Section: Trigeminal Sensory Neuronsmentioning

confidence: 94%

A TRiP Through the Roles of Transient Receptor Potential Cation Channels in Type 2 Upper Airway Inflammation

Backaert

Steelant

Hellings

et al. 2021

Curr Allergy Asthma Rep

View full text Add to dashboard Cite

Purpose of Review Despite their high prevalence, the pathophysiology of allergic rhinitis (AR) and chronic rhinosinusitis (CRS) remains unclear. Recently, transient receptor potential (TRP) cation channels emerged as important players in type 2 upper airway inflammatory disorders. In this review, we aim to discuss known and yet to be explored roles of TRP channels in the pathophysiology of AR and CRS with nasal polyps. Recent Findings TRP channels participate in a plethora of cellular functions and are expressed on T cells, mast cells, respiratory epithelial cells, and sensory neurons of the upper airways. In chronic upper airway inflammation, TRP vanilloid 1 is mostly studied in relation to nasal hyperreactivity. Several other TRP channels such as TRP vanilloid 4, TRP ankyrin 1, TRP melastatin channels, and TRP canonical channels also have important functions, rendering them potential targets for therapy. Summary The role of TRP channels in type 2 inflammatory upper airway diseases is steadily being uncovered and increasingly recognized. Modulation of TRP channels may offer therapeutic perspectives.

show abstract

“…The mouth was maintained in an open state using a mouth opener under a constantly adjusted depth of anesthesia. The intensity of the mechanical stimulation was gradually increased at a specified speed (0–100 g, 10 g/s, cutoff: 100 g), and the lowest intensity of mechanical stimulus required to induce a head withdrawal reflex was defined as the mechanical head withdrawal threshold (MHWT) [ 62 , 63 ]. Each stimulation interval was 3 min, and the average of three measurements was defined as MHWT in each mouse.…”

Section: Methodsmentioning

confidence: 99%

Aging-Related Phenotypic Conversion of Medullary Microglia Enhances Intraoral Incisional Pain Sensitivity

Ikutame

Urata

Oto

et al. 2020

IJMS

Self Cite

View full text Add to dashboard Cite

Activated microglia involved in the development of orofacial pain hypersensitivity have two major polarization states. The aim of this study was to assess the involvement of the aging-related phenotypic conversion of medullary microglia in the enhancement of intraoral pain sensitivity using senescence-accelerated mice (SAM)-prone/8 (SAMP8) and SAM-resistant/1 (SAMR1) mice. Mechanical head-withdrawal threshold (MHWT) was measured for 21 days post palatal mucosal incision. The number of CD11c-immunoreactive (IR) cells [affective microglia (M1)] and CD163-IR cells [protective microglia (M2)], and tumor-necrosis-factor-α (TNF-α)-IR M1 and interleukin (IL)-10-IR M2 were analyzed via immunohistochemistry on days 3 and 11 following incision. The decrease in MHWT observed following incision was enhanced in SAMP8 mice. M1 levels and the number of TNF-α-IR M1 were increased on day 3 in SAMP8 mice compared with those in SAMR1 mice. On day 11, M1 and M2 activation was observed in both groups, whereas IL-10-IR M2 levels were attenuated in SAMP8 mice, and the number of TNF-α-IR M1 cells increased, compared to those in SAMR1 mice. These results suggest that the mechanical allodynia observed following intraoral injury is potentiated and sustained in SAMP8 mice due to enhancement of TNF-α signaling, M1 activation, and an attenuation of M2 activation accompanying IL-10 release.

show abstract

Involvement of transient receptor potential vanilloid 2 in intra‐oral incisional pain

Abstract: The increased expression of TRPV2 in peptidergic TG neurons innervating the incisional buccal mucosa is predominantly involved in buccal mucosal heat hyperalgesia and mechanical allodynia following buccal mucosal incision.

Cited by 7 publications

References 27 publications

Increase in IGF-1 Expression in the Injured Infraorbital Nerve and Possible Implications for Orofacial Neuropathic Pain

Increase in IGF-1 Expression in the Injured Infraorbital Nerve and Possible Implications for Orofacial Neuropathic Pain

A TRiP Through the Roles of Transient Receptor Potential Cation Channels in Type 2 Upper Airway Inflammation

Aging-Related Phenotypic Conversion of Medullary Microglia Enhances Intraoral Incisional Pain Sensitivity

Contact Info

Product

Resources

About