Involvement of thromboxane A2 and peptide leukotrienes in early and late phase nasal blockage in a guinea pig model of allergic rhinitis

Yamasaki, Masashi; Mizutani, Nobuaki; Sasaki, K; Nabe, Takeshi; Matsumoto, Takuya; Ashida, Yuzuru; Kohno, Shigekatsu

doi:10.1007/pl00000272

Cited by 41 publications

(42 citation statements)

References 29 publications

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“…A CysLT1-receptor antagonist, pranlukast, is now clinically used for treatment of allergic rhinitis in Japan. On the other hand, an involvement of CysLTs in the nasal obstruction has also been suggested in a guinea pig model of allergic rhinitis Yamasaki et al, 2001). Antigen inhalation to sensitized guinea pigs caused an increase in CysLTs in nasal cavity lavage fluids (Yamasaki et al, 2001).…”

Section: Resultsmentioning

confidence: 99%

“…On the other hand, an involvement of CysLTs in the nasal obstruction has also been suggested in a guinea pig model of allergic rhinitis Yamasaki et al, 2001). Antigen inhalation to sensitized guinea pigs caused an increase in CysLTs in nasal cavity lavage fluids (Yamasaki et al, 2001). The increase in upper airway resistance, an index of nasal obstruction, induced by antigen challenge in sensitized guinea pigs was inhibited by treatment with pranlukast Yamasaki et al, 2001).…”

Section: Resultsmentioning

confidence: 99%

“…Antigen inhalation to sensitized guinea pigs caused an increase in CysLTs in nasal cavity lavage fluids (Yamasaki et al, 2001). The increase in upper airway resistance, an index of nasal obstruction, induced by antigen challenge in sensitized guinea pigs was inhibited by treatment with pranlukast Yamasaki et al, 2001). Moreover, LTD4 has an ability to induce a relaxation of nasal vasculature both in vivo and in vitro .…”

Section: Resultsmentioning

confidence: 99%

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Involvements of cysteinyl leukotrienes and nitric oxide in antigen-induced venodilatation of nasal mucosa in sensitized rats in vivo

Chiba

Oshita

Sakai

et al. 2007

J. Smooth Muscle Res.

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To determine an in vivo venodilatation of nasal mucosa, which is thought to be one of the causes of nasal obstruction in allergic rhinitis, venous diameters of nasal septa were directly measured in anesthetized rats. An application of antigen to nasal mucosa of sensitized rats caused an increase in diameters of mucosal veins, that is, venodilatation: the maximal response (about 20% increase in diameters) was observed at 55 min after antigen challenge. The antigen-induced increase in venous diameter of nasal mucosa was significantly inhibited by pretreatment with a cysteinyl leukotrienes (CysLTs) receptor antagonist, SR2640, and a nitric oxide (NO) synthase inhibitor, N G -monomethyl-L-arginine, indicating that CysLTs and NO might be involved in the venodilatation of nasal mucosa induced by antigen challenge. Blocking the action of CysLTs and NO might be therefore useful for the therapy of nasal obstruction in allergic rhinitis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Involvements of cysteinyl leukotrienes and nitric oxide in antigen-induced venodilatation of nasal mucosa in sensitized rats in vivo

Chiba

Oshita

Sakai

et al. 2007

J. Smooth Muscle Res.

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“…In a previous study, we found that sneezing induced within 1 h after challenge was almost completely suppressed by treatment with anti-histaminic drugs (19). This indicates that histamine released from mast cells immediately after pollen inhalation challenge plays a major role in the occurrence of sneezing.…”

Section: Discussionmentioning

confidence: 80%

“…From our previous findings regarding induction mechanisms of the nasal blockage, we can speculate two mechanisms: 1) Because we have demonstrated that cyteinyl leukotrienes (CysLTs) and thronboxane A 2 (TXA 2 ) are largely involved in the late phase nasal blockage (19,20), the aggravation of antigen-induced nasal blockage by the long-term treatment with BaP or 1-NP might be due to up-regulation of CysLT 1 and / or TP receptors and / or increases in the production of CysLTs and/ or TXA 2 . 2) Since the nasal blockage in our model is partly but significantly mediated by reactive oxygen species (ROS) (Mizutani et al, unpublished data) and antigen-induced production of ROS can be increased by treatments with DEP in sensitized rats (21), BaP and 1-NP also might up-regulate production of Each data value represents the mean ± S.E.M.…”

Section: Discussionmentioning

confidence: 99%

Polycyclic Aromatic Hydrocarbons Aggravate Antigen-Induced Nasal Blockage in Experimental Allergic Rhinitis

et al. 2007

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Abstract. It has been hypothesized that air pollution has played a role in the increase in allergy prevalence. However, it remains unclear what exact roles are played by polycyclic aromatic hydrocarbons (PAHs), which are encountered in the environment in the form of air pollution, in allergic rhinitis. Thus, we examined whether benzo(a)pyrene (BaP) and 1-nitropyrene (1-NP), representative PAHs, aggravate allergic rhinitis symptoms, using a guinea-pig model. Sensitized animals were repeatedly challenged by inhalation of Japanese cedar pollen once a week. BaP or 1-NP was daily and intranasally administered for 2 weeks (short-term treatment) or for 22 weeks from the time before the sensitization period (long-term treatment). The short-term treatment affected neither nasal blockage nor sneezing induced by antigen. In contrast, the long-term treatment aggravated the antigen-induced nasal blockage that was induced 7 weeks after the start of the treatment with BaP or 1-NP. This aggravation continued during the intranasal treatment with PAH. However, neither sneezing nor Cry j 1-specific IgE antibody production was affected even by the long-term treatment. In conclusion, the long-term treatment with BaP and 1-NP can aggravate allergic rhinitis. The mechanisms underlying this aggravation are not associated with production of Cry j 1-specific IgE.

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Effect of Ganoderma lucidum on Pollen‐induced Biphasic Nasal Blockage in a Guinea Pig Model of Allergic Rhinitis

Mizutani

Nabe

Shimazu

et al. 2011

Phytotherapy Research

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Ganoderma lucidum (GL), an oriental medical mushroom, has been used in Asia for the prevention and treatment of a variety of diseases. However, the effect of GL on allergic rhinitis has not been well defined. The current study describes the inhibitory effect of GL on the biphasic nasal blockage and nasal hyperresponsiveness induced by repeated antigen challenge in a guinea pig model of allergic rhinitis. Intranasally sensitized guinea pigs were repeatedly challenged by inhalation of Japanese cedar pollen once every week. Ganoderma lucidum was orally administered once daily for 8 weeks from the time before the first challenge. The treatment with GL dose-dependently inhibited the early and late phase nasal blockage at the fifth to ninth antigen challenges. Furthermore, nasal hyperresponsiveness to intranasally applied leukotriene D₄ on 2 days after the eighth antigen challenge was also inhibited by the treatment with GL. However, Cry j 1-specific IgE antibody production was not affected by the treatment. In conclusion, we demonstrated that the pollen-induced biphasic nasal blockage and nasal hyperresponsiveness were suppressed by the daily treatment with GL in the guinea pig model of allergic rhinitis. These results suggest that GL may be a useful therapeutic drug for treating patients with allergic rhinitis.

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Involvement of thromboxane A2 and peptide leukotrienes in early and late phase nasal blockage in a guinea pig model of allergic rhinitis

Abstract: These results suggest that TXA2 and p-LTs, but not histamine, play important roles in both the early and the late phase nasal blockage in this model of allergic rhinitis.

Cited by 41 publications

References 29 publications

Involvements of cysteinyl leukotrienes and nitric oxide in antigen-induced venodilatation of nasal mucosa in sensitized rats in vivo

Involvements of cysteinyl leukotrienes and nitric oxide in antigen-induced venodilatation of nasal mucosa in sensitized rats in vivo

Polycyclic Aromatic Hydrocarbons Aggravate Antigen-Induced Nasal Blockage in Experimental Allergic Rhinitis

Effect of Ganoderma lucidum on Pollen‐induced Biphasic Nasal Blockage in a Guinea Pig Model of Allergic Rhinitis

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