Involvement of the β-diketone moiety in the antioxidative Mechanism of Tetrahydrocurcumin

Curcumin as “Curecumin”: From kitchen to clinic

“…Although most studies indicate that curcumin glucuronides and THC are less active than curcumin [154,166], others suggest otherwise [20,21,89,[167][168][169][170][171][172]. The differences in results so far are most likely due to the assays employed.…”

Effects of Farmyard Manure On Growth and Yield of Turmeric (Curcuma LongaL.) Cultivated in Dark-Red Soil, Red Soil andgray Soil in Okinawa, Japan

“…Therefore, utilization of farmyard manure in agriculture is recommended for retaining productivity of problem soils, reducing the usages of chemical fertilizer, improving economy in agriculture and minimizing environmental problems (Sharifuddin and Zaharah, 1991;Neera et al, 1999;Whalen et al, 2003;Xiao et al, 2006). Turmeric is a horticultural root-crop that is important not only as a spice and cosmetic, but also as a medicinal plant worldwide (Hermann and Martin, 1991;Osawa et al, 1995;Sugiyama et al, 1996;Nakamura et al, 1998;Ishimine et al, 2003;Hossain et al, 2005a, b). Considering the medicinal values of turmeric and environmental problems caused by chemicals application, it is important to cultivate turmeric using organic fertilizer (e.g.…”

Oxidative Stress and Cardiovascular Dysfunction Associated with Cadmium Exposure: Beneficial Effects of Curcumin and Tetrahydrocurcumin

“…3) (Okada et al 2001;Anand et al 2008). It has been suggested that the beta-diketone moiety of tetrahydrocurcumin causes antioxidant activity by cleavage of the C-C bond at the active methylene carbon between two carbonyls in the beta-diketone moiety (Sugiyama et al 1996). Compared with curcumin, tetrahydrocurcumin is more soluble in aqueous media, more easily absorbed through the gastrointestinal tract, and more stable in physiological conditions (Okada et al 2001;Wu et al 2014).…”

“…Compared with curcumin, tetrahydrocurcumin is more soluble in aqueous media, more easily absorbed through the gastrointestinal tract, and more stable in physiological conditions (Okada et al 2001;Wu et al 2014). Tetrahydrocurcumin displays the same physiological and pharmacological properties as curcumin, and in some aspects it may exert greater antioxidant (Aggarwal et al 2015) and pharmacological activity than curcumin (Sugiyama et al 1996;Pari and Amali 2005;Somparn et al 2007). In some systems, tetrahydrocurcumin is a more potent free radical scavenger of tert-butoxyl, peroxyl and DPPH radicals than other curcuminoids.…”

“…In some systems, tetrahydrocurcumin is a more potent free radical scavenger of tert-butoxyl, peroxyl and DPPH radicals than other curcuminoids. Further, tetrahydrocurcumin is more effective in inhibiting red blood cell hemolysis and reducing lipid peroxidation in rabbit erythrocyte membrane ghosts and rat liver microsomes (Osawa et al 1995;Sugiyama et al 1996). In cholesterol-fed rabbits, tetrahydrocurcumin inhibits oxidative modification of LDL and shows protective effects against oxidative stress (Naito et al 2002).…”