Involvement of the α1-adrenoceptor in sleep–waking and sleep loss-induced anxiety behavior in zebrafish

Singh, A. K.; Subhashini, N; Sharma, Sudha; Mallick, Birendra Nath

doi:10.1016/j.neuroscience.2013.04.026

Cited by 31 publications

(26 citation statements)

References 59 publications

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“…Our data support earlier studies in zebrafish that showed that disturbances during the night negatively impact zebrafish behaviour (Löhr and Hammerschmidt, 2011;Singh et al, 2013). Furthermore, in rats, UCS during the resting phase has more impact than during the active phase (Aslani et al, 2014).…”

Section: Inhibitory Avoidance Learningsupporting

confidence: 91%

“…Zebrafish are active during the daytime and rest during the night-time (Hurd et al, 1998). Disturbances during the night-time may negatively impact zebrafish behaviour (Löhr and Hammerschmidt, 2011;Singh et al, 2013). We therefore studied the effects of daytime and night-time UCS on inhibitory avoidance learning, whole-body cortisol content and gene expression levels, notably of grα and grβ, in TLF zebrafish to further assess the usefulness of zebrafish as an animal model in research related to chronic stress.…”

Section: Introductionmentioning

confidence: 99%

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Unpredictable chronic stress decreases inhibitory avoidance learning in Tuebingen Long-Fin zebrafish (Danio rerio Hamilton): stronger effects in the resting phase than in the active phase

Manuel

Gorissen

Zethof

et al. 2014

Journal of Experimental Biology

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Zebrafish (Danio rerio Hamilton) are increasingly used as a model to study the effects of chronic stress on brain and behaviour. In rodents, unpredictable chronic stress (UCS) has a stronger effect on physiology and behaviour during the active phase than during the resting phase. Here, we applied UCS during the daytime (active phase) for 7 and 14 days or during the night-time (resting phase) for 7 nights in an in-house-reared Tuebingen long-fin (TLF) zebrafish strain. Following UCS, inhibitory avoidance learning was assessed using a 3 day protocol where fish learn to avoid swimming from a white to a black compartment where they will receive a 3 V shock. Latencies of entering the black compartment were recorded before training (day 1; first shock) and after training on day 2 (second shock) and day 3 (no shock, tissue sampling). Fish whole-body cortisol content and expression levels of genes related to stress, fear and anxiety in the telencephalon were quantified. Following 14 days of UCS during the day, inhibitory avoidance learning decreased (lower latencies on days 2 and 3); minor effects were found following 7 days of UCS. Following 7 nights of UCS, inhibitory avoidance learning decreased (lower latency on day 3). Whole-body cortisol levels showed a steady increase compared with controls (100%) from 7 days of UCS (139%), to 14 days of UCS (174%) to 7 nights of UCS (231%), suggestive of an increasing stress load. Only in the 7 nights of UCS group did expression levels of corticoid receptor genes (mr, grα, grβ) and of bdnf increase. These changes are discussed as adaptive mechanisms to maintain neuronal integrity and prevent overload, and as being indicative of a state of high stress load. Overall, our data suggest that stressors during the resting phase have a stronger impact than during the active phase. Our data warrant further studies on the effect of UCS on stress axis-related genes, especially grβ; in mammals this receptor has been implicated in glucocorticoid resistance and depression.

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Section: Inhibitory Avoidance Learningsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Unpredictable chronic stress decreases inhibitory avoidance learning in Tuebingen Long-Fin zebrafish (Danio rerio Hamilton): stronger effects in the resting phase than in the active phase

Manuel

Gorissen

Zethof

et al. 2014

Journal of Experimental Biology

View full text Add to dashboard Cite

show abstract

“…Some other anxiety measurement tests and protocols were used among the selected articles, however, they were not included in the cluster three meta-analyses as they were used and reported in only one article each. This was the case for the hole board test (Pokk and Zharkovsky, 1998b), the grooming analysis algorithm (Pires et al, 2013), the open field with starter box (Tartar et al, 2009), the light-dark explorations test (Vollert et al, 2011b), the elevated T maze (Süer et al, 2011) and the light-dark box in zebrafish (Singh et al, 2013). Individually, the majority of these tests also demonstrated decreased anxiety in sleep deprived animals, with the exception of the grooming analysis algorithm and the light-dark box in zebrafish, in which results demonstrated an anxiogenic status due to sleep deprivation.…”

Section: Discussionmentioning

confidence: 98%

“…Overall, 50 articles composed our sample (Alvarenga et al, 2008;Andersen et al, 2005;Araujo et al, 2006;Berro et al, 2014;Cohen et al, 2012;Cortese et al, 2010;de Oliveira et al, 2004;Dubiela et al, 2011;Fernandes-Santos et al, 2012;Garg and Kumar, 2008;Hajali et al, 2012;Kalonia and Kumar, 2007;Kumar and Garg, 2008;Kumar and Kalonia, 2007;Kumar and Singh, 2007, 2008Nair et al, 2011;Novati et al, 2011;Patti et al, 2010;Perry et al, 2008;Pires et al, 2013;Pokk et al, 1996;Pokk et al, 2000;Väli, 2001a, b, 2002;Pokk and Zharkovsky, 1995, 1997, 1998aPolesel et al, 2014;Porsolt et al, 1978;Rothman et al, 2013;Silva et al, 2004a;Silva et al, 2004b;Singh and Kumar, 2008;Singh et al, 2013;Suchecki et al, 2002;Süer et al, 2011;Takatsu-Coleman et al, 2013;Tartar et al, 2009;Torabi-Namia et al, 2012;Vassiljev et al, 2000;Vollert et al, 2011a;…”

Section: Selected Studies and Sample Descriptionmentioning

confidence: 99%