Involvement of the Thalamus, Hippocampus, and Brainstem in Hypsarrhythmia of West Syndrome: Simultaneous Recordings of Electroencephalography and fMRI Study

Maki, Yuki; Natsume, Jun; Ito, Yuji; Okai, Yu; Bagarinao, Epifanio; Yamamoto, Hiroyuki; Ogaya, S.; Takeuchi, T. T.; Fukasawa, Toshio; Sawamura, Fumi; Mitsumatsu, T.; Maesawa, Satoshi; Saito, Ryuta; Takahashi, Yoshiyuki; Kidokoro, Hiroyuki

doi:10.3174/ajnr.a7646

Cited by 5 publications

(1 citation statement)

References 24 publications

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“…Assessment of hemodynamic responses by simultaneous EEG and functional magnetic resonance imaging (fMRI) has revealed that high-voltage slow waves are produced from subcortical structures including the thalamus, hippocampus, and brainstem nuclei [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

The Electroencephalographic Characterization of Hypsarrhythmia in Older Pediatric Population With Epilepsy Using Computer-Added Quantitative Methods

Jha¹,

Kumar²,

Zabihullah³

et al. 2023

Cureus

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BackgroundHypsarrhythmia is a classical multifocal electroencephalographic finding in patients of infantile spasm and related epileptic syndromes of early childhood including West syndrome and Otahara syndrome. It usually presents in early infancy and persists up to the age of two years, after which it usually resolves. The persistence of hypsarrhythmia beyond the age of two years has rarely been reported in the literature. The present study is an attempt to investigate and compare the origin and activation pattern of epileptic activity between the subjects aged 3-10 years with and without hypsarrythmia. Material and methodsForty-one patients in the age group of 3-10 years with features suggestive of seizure have been studied for quantitative electroencephalographic characteristics after dividing into hypsarrythmic and normal seizure patterns. ResultThe power spectral density (PSD) of 15 patients with hypsarrhythmia showed a significantly predominant delta frequency in quantitative electrography (qEEG) in comparison to the seizure subjects with normal electroencephalography (EEG) patterns. The amplitude progression analysis of both groups showed that the origin of focus of the hypsarrhythmic pattern is from the occipital region while no such pattern has been noticed in the control group. Discussion and conclusionHypsarrythmia is known to show multifocal origin. Predominant occipital origin in older age group subjects distinguishes the condition from classical hypsarrythmia of early childhood. The occipital origin may be indicative of persistent immaturity of the thalamocortical synaptic pathway.

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Section: Introductionmentioning

confidence: 99%