2012
DOI: 10.1271/bbb.120123
|View full text |Cite
|
Sign up to set email alerts
|

Involvement of the Skeletal Renin-Angiotensin System in Age-Related Osteoporosis of Ageing Mice

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

2
37
0

Year Published

2014
2014
2020
2020

Publication Types

Select...
6
2

Relationship

3
5

Authors

Journals

citations
Cited by 53 publications
(40 citation statements)
references
References 27 publications
2
37
0
Order By: Relevance
“…Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as an internal control was used to normalize the data to determine the relative expression of the target genes. The PCR primers used in this study were as previously described [16,17,29].…”
Section: Rt-pcrmentioning
confidence: 99%
See 1 more Smart Citation
“…Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as an internal control was used to normalize the data to determine the relative expression of the target genes. The PCR primers used in this study were as previously described [16,17,29].…”
Section: Rt-pcrmentioning
confidence: 99%
“…Functional studies revealed that Ang II could stimulate the differentiation and activity of osteoclasts in vivo [14] and in vitro [15] and aggravate the loss of bone minerals in rats with osteoporosis induced by estrogen deficiency [14]; furthermore, the AT1R knockout mice showed high bone mass [16]. In addition, we recently demonstrated that the local RAS in bone was involved in age-related osteoporosis of aging mice [17], bone deteriorations of mice with either obstructive nephropathy [18] or type 1 diabetes [19], and others elucidated the involvement of skeletal RAS in the process of fracture healing in a mouse femur fracture model [20] and the steroid-induced osteonecrosis in rabbits [21] as well as the development of postmenopausal osteoporosis in ovariectomized (OVX) animal models [14,22]. Therefore, the emerging evidences demonstrated that the local RAS displays important biological actions in bone tissue.…”
Section: Introductionmentioning
confidence: 99%
“…6) Recent in vivo studies showed that the components of RAS, such as renin, angiotensin-converting enzyme (ACE), and angiotensin II (Ang II) receptors, were expressed in the local milieu of bone, [7][8][9][10] and in vitro study identified the expression of Ang II receptors in primary osteoblasts derived from newborn mouse calvaria, 7) indicating the components of RAS are expressed locally in bone microenvironment. Our further animal studies demonstrated that the local RAS in bone was involved in age-related osteoporosis of aging mice, 11) and bone deteriorations of mice with either obstructive nephropathy 12) or type 1 diabetes. 13) Other groups elucidated the involvement of skeletal RAS in the process of fracture healing in a mouse femur fracture model, 14) and the steroid-induced osteonecrosis in rabbits 10) as well as the development of postmenopausal osteoporosis in ovariectomized (OVX) animal models 15,16) and glucocorticoid-induced osteoporosis.…”
mentioning
confidence: 63%
“…13) In addition, we recently demonstrated that the local RAS in bone was involved in age-related osteoporosis of aging mice, 14) bone deteriorations of mice with either obstructive nephropathy 15) or type 1 diabetes, 16) and others elucidated the involvement of skeletal RAS in the process of fracture healing in a mouse femur fracture model. 17) Therefore, the local RAS displays important biological actions in bone tissue.…”
Section: )mentioning
confidence: 99%
“…9,10) Functional studies revealed that ANG II could stimulate the differentiation and activity of osteoclasts in vivo 11) and in vitro, 12) and aggravate the loss of bone minerals in rats with osteoporosis induced by estrogen deficiency, 11) furthermore, the ANG II type 1 receptor knockout mice showed high bone mass. 13) In addition, we recently demonstrated that the local RAS in bone was involved in age-related osteoporosis of aging mice, 14) bone deteriorations of mice with either obstructive nephropathy 15) or type 1 diabetes, 16) and others elucidated the involvement of skeletal RAS in the process of fracture healing in a mouse femur fracture model. 17) Therefore, the local RAS displays important biological actions in bone tissue.…”
mentioning
confidence: 99%