Involvement of the Retinoid X Receptor in the Development of Imposex Caused by Organotins in Gastropods

Nishikawa, J; Mamiya, Satoru; Kanayama, Tomohiko; Nishikawa, Takeshi; Shiraishi, Fujio; Horiguchi, T.

doi:10.1021/es049593u

Cited by 292 publications

(198 citation statements)

References 41 publications

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“…Most significantly TBTO was found to be inhibitory to both plaice PPARα and PPARβ at concentrations as low as 1nM in cellular transfection assays. Recently TBTO and its analogs have been found to be potent nM agonists of mammalian and amphibian PPARγ and of mammalian and gastropod mollusc RXR (Nishikawa et al, 2004;Hiromori et al, 2009;Grün et al, 2006). The activation of RXR by TBT may underly the development of imposex in wild populations of molluscs (Nishikawa et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Tributyltin is a potent inhibitor of piscine peroxisome proliferator-activated receptor α and β

Colliar

Sturm

Leaver

2011

Comparative Biochemistry and Physiology Part C: Toxicology &

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Section: Discussionmentioning

confidence: 99%

Tributyltin is a potent inhibitor of piscine peroxisome proliferator-activated receptor α and β

Colliar

Sturm

Leaver

2011

Comparative Biochemistry and Physiology Part C: Toxicology &

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“…TBT has been proved to interfere with the esterification of testosterone, resulting in elevated free testosterone levels (Gooding et al 2003). In a recent study, Nishikawa et al (2004) suggested that retinoid X receptors play an important role in inducing the development of imposex. To date, although several hypotheses have been proposed, the exact biochemical mechanisms of imposex have not yet been fully revealed (Matthiessen & Gibbs 1998).…”

Section: Effect Of Male Structurementioning

confidence: 99%

Generalized system of imposex and reproductive failure in female gastropods of coastal waters of mainland China

Shi¹,

Huang²,

Zhu³

et al. 2005

Mar. Ecol. Prog. Ser.

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We investigated the occurrence of imposex in gastropods from the coastal waters of mainland China from November 1999 to July 2004. Imposex was found in 30 species from 8 families, and was recorded in 20 species for the first time. In addition to the already known phenotypes of imposex expression in Cantharus cecillei, we also found aborted egg capsules in specimens with a split ventral channel (stage and type classification: S 6c* ) and various extensions of the proximal vas deferens (PVD). The PVD went up to or passed by the vaginal opening, and then it stopped or continued along the capsule gland. In imposex females, the penis shape and the development of the vas deferens were similar to those of the male of the same species. The morphological expressions of imposex showed diverse stages and types. Reproductive failure of females occurred in 13 species. The results suggest that imposex is widespread and severe in the coastal waters of China. Based on our aims of ecological and morphological significance, a typical imposex classification could be further generalized for all 30 species by adding S 6c(*) and 2 subdivisions of the PVD. The generalized scheme was also ascertained to be valid for several morphological variations of imposex in previous work. Sterility at S 6c(*) was proven to be due to the infolding of the capsule gland wall. We thus summed up 4 mechanisms of sterility (a, b, c and *) in females. Furthermore, it was shown that the normal structure of the male genital system also affected the morphological expressions of imposex to some degree, which we referred to as 'effect of male structure'. Finally, we put forward a general classification scheme of imposex with an integrated system of aims, criteria, stages, types (subtypes), pathways and mechanisms of imposex. KEY WORDS: Imposex · Gastropod · Sterility · Mainland ChinaResale or republication not permitted without written consent of the publisher

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“…There exist a number of nuclear hormone receptors such as the ER, androgen receptor (AR), thyroid receptor (TR), retinoic acid receptor (RAR), and vitamin D receptor (VDR), which mediate the actions of hormones and vitamins to affect processes from reproduction to development and even general metabolism (8). Thus, environmental pollutants binding to a wide variety of nuclear hormone receptors could induce adverse effects in wildlife (9), as exemplified by a recent study that organotins caused imposex in gastropods through the involvement of retinoid X receptors (RXRs) (10).…”

Section: Introductionmentioning

confidence: 99%

Identification of Retinoic Acid Receptor Agonists in Sewage Treatment Plants

Zhen

et al. 2009

Environ. Sci. Technol.

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Retinoic acid receptor (RAR) agonists are speculated to be one possible cause for the widely observed frog deformities in North America, although little is known about the specific RAR agonists in aquatic environments. We identified the specific RAR agonists in sewage treatment plants (STPs) and receiving rivers using an RAR yeast two-hybrid bioassay. Water samples were extracted by solid-phase extract cartridges, which were successively eluted by hexane, ethyl acetate, and methanol for bioassay. Among the three fractions, the ethyl acetate fraction showed the highest RAR agonistic activities. The bioassay-derived activity, expressed as all-trans-retinoic acid (all-trans-RA) equivalents (ATRA-EQ) were 10.9 ( 2.2 and 1.7 ( 1.0 ng/L in the STP influents and effluents, respectively, while the ATRA-EQs were as high as 7.1 and 8.3 ng/L in the two rivers receiving STP effluents. Following a two-step fractionation using high-performance liquid chromatography and ultraperformance liquid chromatography (UPLC) directed by the bioassay, two bioactive fractions were obtained from Gaobeidian STP influent and all-trans-4-oxo-RA (4.7-10.4 ng/L in influents, <0.2-0.9 ng/L in effluents) and 13-cis-4-oxo-RA (2.3-7.1 ng/L in influents, <0.4-1.1 ng/L in effluents) were identified in these fractions with UPLC-MS/MS. The EC 50 for all-trans-4-oxo-RA or 13-cis-4-oxo-RA relative to that of all-trans-RA in exhibiting RARR agonistic activity was calculated to be 3.87 and 0.46, respectively.

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Involvement of the Retinoid X Receptor in the Development of Imposex Caused by Organotins in Gastropods

Cited by 292 publications

References 41 publications

Tributyltin is a potent inhibitor of piscine peroxisome proliferator-activated receptor α and β

Tributyltin is a potent inhibitor of piscine peroxisome proliferator-activated receptor α and β

Generalized system of imposex and reproductive failure in female gastropods of coastal waters of mainland China

Identification of Retinoic Acid Receptor Agonists in Sewage Treatment Plants

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