Involvement of the receptors of the vestibular nucleus in the gaze-holding system of the cat

Mettens, Philippe; Chéron, Guy; Godaux, Emile

doi:10.1016/0304-3940(94)90023-x

Cited by 12 publications

(6 citation statements)

References 12 publications

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“…Chronic infusion of AP5, an NMDA antagonist, into the vestibular nucleus induced massive postural and oculomotor syndromes similar to those observed following acute vestibular deafferentation in guinea pigs (de Waele et al, 1990;Vidal et al, 1996). Injection of AP5 into the MV of alert cats also led to failure in gazeholding (Matterns et al, 1994). Apart from their contribution to the maintenance of posture and eye position, NMDA receptors in the vestibular nucleus are involved in modulating synaptic plasticity, such as long-term potentiation .…”

Section: Nmda Receptor Of Otolith-related Vestibular Nuclear Neuronsmentioning

confidence: 65%

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Developmental maturation of ionotropic glutamate receptor subunits in rat vestibular nuclear neurons responsive to vertical linear acceleration

Lai¹,

Lai²,

Tse³

et al. 2008

Eur J of Neuroscience

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We investigated the maturation profile of subunits of ionotropic glutamate receptors in vestibular nuclear neurons that were activated by sinusoidal linear acceleration along the vertical plane. The otolithic origin of Fos expression in these neurons was confirmed as a marker of functional activation when labyrinthectomized and/or stationary control rats contrasted by showing sporadically scattered Fos-labeled neurons in the vestibular nuclei. By double immunohistochemistry for Fos and one of the receptor subunits, otolith-related neurons that expressed either alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate or N-methyl-d-aspartate subunits were first identified in the medial vestibular nucleus, spinal vestibular nucleus and Group x by postnatal day (P)7, and in the lateral vestibular nucleus and Group y by P9. No double-labeled neurons were found in the superior vestibular nucleus. Within each vestibular subnucleus, these double-labeled neurons constituted approximately 90% of the total Fos-labeled neurons. The percentage of Fos-labeled neurons expressing the GluR1 or NR2A subunit showed developmental invariance in all subnuclei. For Fos-labeled neurons expressing the NR1 subunit, similar invariance was observed except that, in Group y, these neurons decreased from P14 onwards. For Fos-labeled neurons expressing the GluR2, GluR2/3, GluR4 or NR2B subunit, a significant decrease was found by the adult stage. In particular, those expressing the GluR4 subunit showed a two- to threefold decrease in the medial vestibular nucleus, spinal vestibular nucleus and Group y. Also, those expressing the NR2B subunit showed a twofold decrease in Group y. Taken together, the postsynaptic expression of ionotropic glutamate receptor subunits in different vestibular subnuclei suggests that glutamatergic transmission within subregions plays differential developmental roles in the coding of gravity-related vertical spatial information.

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Section: Nmda Receptor Of Otolith-related Vestibular Nuclear Neuronsmentioning

confidence: 65%

“…, 1996). Injection of AP5 into the MV of alert cats also led to failure in gaze‐holding (Matterns et al. , 1994).…”

Section: Discussionmentioning

confidence: 99%

Developmental maturation of ionotropic glutamate receptor subunits in rat vestibular nuclear neurons responsive to vertical linear acceleration

Lai¹,

Lai²,

Tse³

et al. 2008

Eur J of Neuroscience

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“…NMDA receptors are important components of brain stem oculomotor nuclei (Bosco et al 1994;Watanabe et al 1994), and their peripheral or direct blockade with NMDA antagonists results in nystagmus in the cat (Godaux et al 1990;Mettens et al 1994). Also, ketamine often induces nystagmus during routine clinical use.…”

Section: Discussionmentioning

confidence: 99%

Does Ketamine-Mediated N-methyl-D-aspartate Receptor Antagonism Cause Schizophrenia-like Oculomotor Abnormalities?

Radant

Bowdle

Cowley

et al. 1998

Neuropsychopharmacology

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“…Increasing the time constant of the decay of the response can easily be accomplished by having the excitation of the postsynaptic neurons mediated by a balance of N-methyl-D-aspartate (NMDA) and AMPA receptors (Landfield and Deadwyler 1988). NMDA receptors are known to exist in the vestibular nucleus, are implicated in restoring the VOR after a lesion (Caria et al 1996;Grassi et al 1998;Grassi and Pettorossi 2000), and participate in gaze holding (Mettens et al 1994). Extending the time constant of the membrane would lead to a more robust and stable velocity to position integrator (Seung et al 2000;Shen 1989).…”

Section: Model Of Tcementioning

confidence: 99%

Asymmetric Integration Recorded From Vestibular-Only Cells in Response to Position Transients

Musallam¹,

Tomlinson

2002

Journal of Neurophysiology

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Angular and translational accelerations excite the semicircular canals and otolith organs, respectively. While canal afferents approximately encode head angular velocity due to the biomechanical integration performed by the canals, otolith signals have been found to approximate head translational acceleration. Because central vestibular pathways require velocity and position signals for their operation, the question has been raised as to how the integration of the otolith signals is accomplished. We recorded responses from 62 vestibular-only neurons in the vestibular nucleus of two monkeys to position transients in the naso-occipital and interaural orientations and varying directions in between. Responses to the transients were directionally asymmetric; one direction elicited a response that approximated the integral of the acceleration of the stimulus. In the opposite direction, the cells simply encoded the acceleration of the motion. We present a model that suggests that a neural integrator is not needed. Instead a neuron with a long membrane time constant and an excitatory postsynaptic potential duration that increases with the firing rate of the presynaptic cell can emulate the observed behavior.

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Involvement of the receptors of the vestibular nucleus in the gaze-holding system of the cat

Cited by 12 publications

References 12 publications

Developmental maturation of ionotropic glutamate receptor subunits in rat vestibular nuclear neurons responsive to vertical linear acceleration

Developmental maturation of ionotropic glutamate receptor subunits in rat vestibular nuclear neurons responsive to vertical linear acceleration

Does Ketamine-Mediated N-methyl-D-aspartate Receptor Antagonism Cause Schizophrenia-like Oculomotor Abnormalities?

Asymmetric Integration Recorded From Vestibular-Only Cells in Response to Position Transients

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