Abstract:Parathyroid
hormone-related protein (PTHrP), which is secreted
from a tumor, contributes to the progression of cachexia, a condition
that is observed in half of all cancer patients. Although drug clearance
was reported to decrease in patients with cancer cachexia, the details
have not been clarified. The present study reports on an investigation
of whether PTHrP is involved in the alternation of drug metabolism
in cases of cancer cachexia. Cancer cachexia model rats with elevated
serum PTHrP levels showed a si… Show more
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