Involvement of the neuropeptide corticotropin-releasing hormone in an animal model of Shigella-related seizures

Yuhas, Yael; Weizman, Abraham; Chrousos, George P.; Ovadia, Hilla; Ashkenazi, Shai

doi:10.1016/j.jneuroim.2004.04.009

Cited by 10 publications

(9 citation statements)

References 13 publications

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“…Elevated levels of CRH are found in inflammatory sites of any etiology in the CNS, and CRH has neurotoxic and kindling effects 24 . CRH‐R1 antagonists exert protective effects in rat models of permanent focal cerebral ischemia and reverse limbic seizures in neonatal rats 25,26 . Stress is associated with activation of intracranial mast cells through the sequential action of CRH and sensory neuropeptides 27 .…”

Section: Discussionmentioning

confidence: 99%

Potential Uses of Corticotropin‐Releasing Hormone Antagonists

Zoumakis

Rice

Gold

et al. 2006

Annals of the New York Academy of Sciences

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Corticotropin-releasing hormone (CRH), its natural homologs urocortins (UCN) 1, 2, and 3, and several types of CRH receptors (R), coordinate the behavioral, endocrine, autonomic, and immune responses to stress. The potential use of CRH antagonists is currently under intense investigation. Selective antagonists have been used experimentally to clarify the role of CRH-related peptides in anxiety and depression, addictive behavior, inflammatory disorders, acute and chronic neurodegeneration, and sleep disorders, as well as preterm labor.

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Section: Discussionmentioning

confidence: 99%

Potential Uses of Corticotropin‐Releasing Hormone Antagonists

Zoumakis

Rice

Gold

et al. 2006

Annals of the New York Academy of Sciences

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“…The incidence of viral infections in the CNS of neonates with seizures of unknown origin may be much higher than previously reported [7,16]. Convulsions are common complications of shigellosis in children [8,17]. Other infected individuals may show refractory status epilepticus, shock [9,18], and epileptic seizures revealing a menses toxic shock syndrome have also been reported [10].…”

Section: Discussionmentioning

confidence: 91%

“…It is also suggested that the causative agents of febrile illness associated with seizures in summer season are primarily enteroviruses, especially coxsackieviruses group A and that febrile seizures might be caused by enteroviral infection in the central nervous system [15,16,17,18,19,34]. Alterations in consciousness, including seizures, delirium, and coma are known to occur during Shigella infection.…”

Section: Microbiological Aspects Of Cryptogenic Epilepsymentioning

confidence: 99%

“…Epileptic seizures are frequently seen after viral encephalitis. Herpes simplex virus type 1 (HSV-1) encephalitis is the most common cause of acquired epilepsy in humans [17,35]. HSV-1 infection induces epileptiform activity, neuron loss, and subsequently, a dramatic increase of mossy fiber sprouting in the supragranular area.…”

Section: Involvement Of Viral Infection In Epilepsiesmentioning

confidence: 99%

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Clinical Microbiological Aspects of Epileptic Seizures in the Tropical Countries with Specific Focus on Nigeria

Kanu

Anyanwu²,

Nwachukwu

et al. 2005

The Scientific World JOURNAL

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Epilepsy is a common neurological disorder; however, in Nigeria and other tropical regions, the causes of epileptic seizures differ greatly in etiology. This paper is an attempt to highlight some possible microbiological aspects of epileptic seizures. A literature review was carried out to identify the extent to which microbial infections were involved in the elicitation of epileptic seizures. Data were collected from several clinics in the community and hospitals in Nigeria and correlated with the evidence from the literature review. It was found that different microbial agents including viral, bacterial, protozoa, and fungal agents were involved in several aspects of epileptic seizures. Malaria was found to cause more than 88% of childhood epileptic seizures and 12% of adult seizures. Generalized tonic-clonic seizures occurred in more than 40% of adult patients. Partial seizures were uncommon. Cases of epileptic seizures associated with bacteria (e.g., brucellosis), viral, fungal, and protozoa infections were frequently reported. Malaria, tapeworm, and cysticercosis were some of the common infectious causes of epilepsy; however, in some cases, the cause remained unknown. From these findings, it was evident that microbiological aspects of epilepsies are possible research areas that might be developed. It is believed that the unraveling of the various microbiological factors in epileptic seizures would have important implications for understanding the underlying neurobiology, evaluating treatment strategies, and perhaps planning health-care resources for the affected. It will also help to improve the prognostic factors in initial seizure symptomatic etiology and presence of any structural cerebral abnormalities.

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“…Tran et al [33], for example, showed that the GABA degradation blocker gamma-vinyl-GABA (VGB) that is used for clinical seizure treatment causes a reduction of both CRH gene expression and secretion in the hypothalamus of 9-day-old rats. Finally, an excess in CRH has been hypothesized to underlie West syndrome, in which seizures during infancy play an important role [34], and CRH has been found to play a role in the increased susceptibility to seizures in shigellosis [35].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Candidate Genes from Orphan FEB and GEFS+ Loci by Analysis of Human Brain Gene Expression Atlases

Piro¹,

Molineris²,

Ala³

et al. 2011

PLoS ONE

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Febrile seizures, or febrile convulsions (FEB), represent the most common form of childhood seizures and are believed to be influenced by variations in several susceptibility genes. Most of the associated loci, however, remain ‘orphan’, i.e. the susceptibility genes they contain still remain to be identified. Further orphan loci have been mapped for a related disorder, genetic (generalized) epilepsy with febrile seizures plus (GEFS+).We show that both spatially mapped and ‘traditional’ gene expression data from the human brain can be successfully employed to predict the most promising candidate genes for FEB and GEFS+, apply our prediction method to the remaining orphan loci and discuss the validity of the predictions. For several of the orphan FEB/GEFS+ loci we propose excellent, and not always obvious, candidates for mutation screening in order to aid in gaining a better understanding of the genetic origin of the susceptibility to seizures.

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Involvement of the neuropeptide corticotropin-releasing hormone in an animal model of Shigella-related seizures

Cited by 10 publications

References 13 publications

Potential Uses of Corticotropin‐Releasing Hormone Antagonists

Potential Uses of Corticotropin‐Releasing Hormone Antagonists

Clinical Microbiological Aspects of Epileptic Seizures in the Tropical Countries with Specific Focus on Nigeria

Evaluation of Candidate Genes from Orphan FEB and GEFS+ Loci by Analysis of Human Brain Gene Expression Atlases

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