Involvement of the mirror neuron system in blunted affect in schizophrenia

Lee, Jung Suk; Chun, Ji Won; Yoon, Sang Duk; Kim, Jae Jin

doi:10.1016/j.schres.2013.10.043

Cited by 41 publications

(44 citation statements)

References 42 publications

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“…Notably, greater mu suppression was associated with higher empathetic perspective-taking and emotional mental state reasoning only in the healthy group. The apparent trend in the reduced mu suppression in schizophrenia patients is in line with our main hypothesis, and with other work demonstrating reduced activity in the MNS in schizophrenia (Enticott et al, 2008;Kato et al, 2011;Lee et al, 2014;Mehta et al, 2013;Singh et al, 2011;Thakkar et al, 2014). However, the lack of significance found in this study implies that this impairment may not be as substantial as some others have suggested.…”

Section: Discussionsupporting

confidence: 91%

“…A number of neuroimaging studies have provided support for the suggestion of a dysfunctional MNS in schizophrenia (Lee, Chun, Yoon, Park, & Kim, 2014;Mehta, Thirthalli, Basavaraju, Gangadhar, & Pascual-Leone, 2013;Thakkar, Peterman, & Park, 2014). One mu rhythm study from Singh, Pineda, and Cadenhead (2011) had healthy controls and firstepisode schizophrenia patients observe videos of different actions and found lower mu suppression in the patient group.…”

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confidence: 99%

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Reward modulates the mirror neuron system in schizophrenia: A study into the mu rhythm suppression, empathy, and mental state attribution

Brown

Gonzalez-Liencres

Taş

et al. 2015

Social Neuroscience

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Impairments in the mirror neuron system (MNS) have been implicated as a possible underlying neurological basis for deficits in higher-level social cognition in schizophrenia. Previous work testing this hypothesis has used the electroencephalographic mu rhythm as an index of MNS activity, with studies showing mixed results. Here we investigated the role that reward plays in modulating the mu rhythm, and its association with empathy and emotional mental state reasoning. A group of schizophrenia patients and a healthy control group completed an action observation paradigm in which they watched actions that were financially rewarding, punishing, or neutral. Patients showed intact reward-related modulation of the mu rhythm, and greater mu suppression was associated with greater negative symptoms. There was also a trend for reduced mu suppression in patients. Furthermore, both empathy and emotional mental state reasoning were associated with the degree of mu suppression, but only in healthy controls. These findings confirm the association between the mu suppression and high-level social cognition. It is possible that schizophrenia patients utilize different cognitive routes to infer mental states. The demonstration that reward influences the degree of mu suppression in schizophrenia patients may help to account for previous conflicting findings in the literature.

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Section: Discussionsupporting

confidence: 91%

mentioning

confidence: 99%

Reward modulates the mirror neuron system in schizophrenia: A study into the mu rhythm suppression, empathy, and mental state attribution

Brown

Gonzalez-Liencres

Taş

et al. 2015

Social Neuroscience

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“…Four studies matched the two groups for years of education (Kato et al, 2011; Mehta et al, 2013c; Park et al, 2009; Varcin et al, 2010), two studies each matched them for IQ (Thakkar et al, 2013; Varcin et al, 2010) and parental education (Andreasen et al, 2008; Horan et al, 2014). All except five studies (Andreasen et al, 2008; Horan et al, 2014; Lee et al, 2013; Mitra et al, 2014; Singh et al, 2011), reported analysis of comparing cortical activity during the control condition of their respective tasks between patients and healthy subjects and found no significant differences. Only one study had antipsychotic-naïve schizophrenia patients (Mehta et al, 2013c); two studies recruited antipsychotic-free patients [i.e., off treatment for >6-months (Kato et al, 2011), >3-weeks (Andreasen et al, 2008) or >4 weeks (Mitra et al, 2014)].…”

Section: Resultsmentioning

confidence: 99%

Mirror neuron dysfunction in schizophrenia and its functional implications: A systematic review

Mehta

Thirthalli

Aneelraj

et al. 2014

Schizophrenia Research

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Dysfunctional mirror neuron activity (MNA) has been posited to underlie diverse symptoms of schizophrenia (e.g., ego-boundary disturbances, negative symptoms, social cognition impairments and catatonic symptoms). In this paper, we systematically review studies that have empirically compared putative MNA in schizophrenia patients and healthy subjects using different neurophysiological probes. Majority of the studies (n=9) reported reduced MNA in patients. Two each reported either increased MNA or mixed (both increased and decreased) results, while only one study reported normal findings. Reduced MNA was associated with greater negative symptoms and theory of mind deficits. The neurophysiological technique, task paradigms used, specific brain regions studied and laterality did not influence these findings. Further, we propose an overarching model to understand the heterogeneous symptom dimensions of schizophrenia, in which an inherent mirror system deficit underlying persistent negative symptoms, social cognition impairments and self-monitoring deficits triggers a pathological metaplastic reorganization of this system resulting in aberrant excessive MNA and the phasic catatonic symptoms, affective instability and hallucinations. Despite being preliminary in nature, evidence of abnormal MNA in schizophrenia reported necessitates more detailed investigation. Future research directions of using this model within the Research Domain Criteria framework of the National Institute of Mental Health are discussed.

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“…Indeed, neuroimaging studies have pointed to abnormal insular involvement in schizophrenic symptoms including auditory-verbal hallucinations (Clos et al, 2014; Dierks et al, 1999; Hoffman et al, 2008; Shergill et al, 2000; Sommer et al, 2008), impairment of verbal fluency (Curtis et al, 1998), working memory (Glahn et al, 2005; Hashimoto et al, 2010) and emotions (Crespo-Facorro et al, 2001; Lee et al, 2014; Phillips et al, 1999; Seiferth et al, 2009). Previous proposals of insular dysfunction in schizophrenia have mainly focused on its role in distinguishing internal and external sensory events (Crespo-Facorro et al, 2000; Wylie and Tregellas, 2010) and salience (Menon and Uddin, 2010).…”

Section: Discussionmentioning

confidence: 99%

Comparison of structural covariance with functional connectivity approaches exemplified by an investigation of the left anterior insula

et al. 2014

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The anterior insula is a multifunctional region involved in various cognitive, perceptual and socio-emotional processes. In particular, a portion of the left anterior insula is closely associated with working memory processes in healthy participants and shows gray matter reduction in schizophrenia. To unravel the functional networks related to this left anterior insula region, we here combined resting state connectivity, meta-analytic-connectivity modeling (MACM) and structural covariance (SC) in addition to functional characterization based on BrainMap meta-data. Apart from allowing new insight into the seed region, this approach moreover provided an opportunity to systematically compare these different connectivity approaches. The results showed that the left anterior insula has a broad response profile and is part of multiple functional networks including language, memory and socio-emotional networks. As all these domains are linked with several symptoms of schizophrenia, dysfunction of the left anterior insula might be a crucial component contributing to this disorder. Moreover, although converging connectivity across all three connectivity approaches for the left anterior insula were found, also striking differences were observed. RS and MACM as functional connectivity approaches specifically revealed functional networks linked with internal cognition and active perceptual/language processes, respectively. SC, in turn, showed a clear preference for highlighting regions involved in social cognition. These differential connectivity results thus indicate that the use of multiple forms of connectivity is advantageous when investigating functional networks as conceptual differences between these approaches might lead to systematic variation in the revealed functional networks.

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Involvement of the mirror neuron system in blunted affect in schizophrenia

Cited by 41 publications

References 42 publications

Reward modulates the mirror neuron system in schizophrenia: A study into the mu rhythm suppression, empathy, and mental state attribution

Reward modulates the mirror neuron system in schizophrenia: A study into the mu rhythm suppression, empathy, and mental state attribution

Mirror neuron dysfunction in schizophrenia and its functional implications: A systematic review

Comparison of structural covariance with functional connectivity approaches exemplified by an investigation of the left anterior insula

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