Involvement of the mediodorsal thalamic nucleus in mediating recollection and familiarity

Zoppelt, Diana; Koch, Benno; Schwarz, Michael; Daum, Irene

doi:10.1016/s0028-3932(03)00019-8

Cited by 73 publications

(70 citation statements)

References 33 publications

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“…In five cases, the infarct involved the medial dorsal nucleus, while in four others the ventral lateral nucleus was damaged, prompting the opportunity to test whether damage to the medial dorsal nucleus might specifically impair familiarity (as predicted by Aggleton and Brown [1999]). Analyses using ROC curves for all nine thalamic patients in a single group indicated decreases in both recollection and familiarity (Zoppelt et al 2003). There was no evidence that those patients with medial dorsal nucleus damage had a greater loss of familiarity (Zoppelt et al 2003).…”

Section: Intralaminar and Midline Thalamic Nucleimentioning

confidence: 83%

“…Analyses using ROC curves for all nine thalamic patients in a single group indicated decreases in both recollection and familiarity (Zoppelt et al 2003). There was no evidence that those patients with medial dorsal nucleus damage had a greater loss of familiarity (Zoppelt et al 2003). However, in none of these cases was the pathology thought to be confined to one nucleus, and it can be assumed that the intralaminar nuclei and the internal medullary lamina would have been variably affected.…”

Section: Intralaminar and Midline Thalamic Nucleimentioning

confidence: 85%

“…While two stroke cases with varying amounts of medial dorsal nucleus damage (in one case, only on the left, the other bilateral) also showed recognition memory deficits (Cipolotti et al 2008), in both cases there was additional damage in other thalamic nuclei, producing a complex pattern of pathology that is difficult to interpret. Another study implicating the medial dorsal nucleus described five patients with unilateral infarcts that involved the medial dorsal nucleus but spread into adjacent regions (Zoppelt et al 2003). The patients showed impaired recognition.…”

Section: Medial Dorsal Thalamic Nucleusmentioning

confidence: 99%

“…This outcome is not surprising given the intimate anatomical relationship between the medial dorsal thalamic nucleus and the prefrontal cortex and the importance of the prefrontal cortex for executive function. In those studies that suggest a more direct contribution for the medial dorsal nucleus to recognition (e.g., Isaac et al 1998;Zoppelt et al 2003;Cipolotti et al 2008), there remain problems regarding the potential contributions from immediately adjacent nuclei and tracts, e.g., the internal medullary lamina.…”

Section: Medial Dorsal Thalamic Nucleusmentioning

confidence: 99%

“…Less support for the two-process model of Aggleton and Brown (1999) comes from an analysis of nine patients with unilateral thalamic infarcts (Zoppelt et al 2003). In five cases, the infarct involved the medial dorsal nucleus, while in four others the ventral lateral nucleus was damaged, prompting the opportunity to test whether damage to the medial dorsal nucleus might specifically impair familiarity (as predicted by Aggleton and Brown [1999]).…”

Section: Intralaminar and Midline Thalamic Nucleimentioning

confidence: 99%

See 4 more Smart Citations

Unraveling the contributions of the diencephalon to recognition memory: A review

Aggleton¹,

Dumont²,

Warburton³

2011

Learn. Mem.

137

111

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Both clinical investigations and studies with animals reveal nuclei within the diencephalon that are vital for recognition memory (the judgment of prior occurrence). This review seeks to identify these nuclei and to consider why they might be important for recognition memory. Despite the lack of clinical cases with circumscribed pathology within the diencephalon and apparent species differences, convergent evidence from a variety of sources implicates a subgroup of medial diencephalic nuclei. It is supposed that the key functional interactions of this subgroup of diencephalic nuclei are with the medial temporal lobe, the prefrontal cortex, and with cingulate regions. In addition, some of the clinical evidence most readily supports dual-process models of recognition, which assume two independent cognitive processes (recollective-based and familiarity-based) that combine to direct recognition judgments. From this array of information a "multi-effect multinuclei" model is proposed, in which the mammillary bodies and the anterior thalamic nuclei are of preeminent importance for recollective-based recognition. The medial dorsal thalamic nucleus is thought to contribute to familiarity-based recognition, but this nucleus, along with various midline and intralaminar thalamic nuclei, is also assumed to have broader, indirect effects upon both recollective-based and familiarity-based recognition.Clinical studies repeatedly show that diencephalic pathology can impair recognition memory. Even so, there is no agreed locus within the diencephalon responsible for this memory loss and, hence, no agreed mechanism to explain the impairment. The present review examines both clinical and animal findings, and from this information a multi-effect multi-nuclei (MEMN) model emerges to explain the contributions of the diencephalon to recognition memory.At the outset, it is necessary to refine the focus of this review and to define some of its principal terms. The diencephalon comprises the thalamus and hypothalamus but, as will be explained, only the more medial parts of the diencephalon will be considered in detail. Recognition memory refers to the ability to detect whether a stimulus (e.g., a word, face, picture, object, or sound) has previously been encountered. As a consequence, this review is not about item identification (sometimes also confusingly referred to as recognition). Likewise, conditions that have broad disruptive effects on cognition, e.g., dementia, will not be considered even though recognition is typically impaired. Distinctions will be made between "item recognition," where the task is to determine if an individual item is novel or familiar, and "associative recognition," where all the individual items being experienced are familiar, but their particular combination is novel. A further, distinct ability is "recency" discrimination-the ability to determine which of two familiar stimuli has been experienced more recently. Both studies of amnesia and electrophysiological recordings show how recency memory and recogniti...

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Section: Intralaminar and Midline Thalamic Nucleimentioning

confidence: 83%

Section: Intralaminar and Midline Thalamic Nucleimentioning

confidence: 85%

Section: Medial Dorsal Thalamic Nucleusmentioning

confidence: 99%

Section: Medial Dorsal Thalamic Nucleusmentioning

confidence: 99%

Section: Intralaminar and Midline Thalamic Nucleimentioning

confidence: 99%

See 3 more Smart Citations

Unraveling the contributions of the diencephalon to recognition memory: A review

Aggleton¹,

Dumont²,

Warburton³

2011

Learn. Mem.

137

111

View full text Add to dashboard Cite

show abstract

Functional neuroimaging of visual creativity: a systematic review and meta‐analysis

et al. 2016

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IntroductionThe generation of creative visual imagery contributes to technological and scientific innovation and production of visual art. The underlying cognitive and neural processes are, however, poorly understood.MethodsThis review synthesizes functional neuroimaging studies of visual creativity. Seven functional magnetic resonance imaging (fMRI) and 19 electroencephalography (EEG) studies were included, comprising 27 experiments and around 800 participants.ResultsActivation likelihood estimation meta‐analysis of the fMRI studies comparing visual creativity to non‐rest control tasks yielded significant clusters in thalamus, left fusiform gyrus, and right middle and inferior frontal gyri. The EEG studies revealed a tendency for decreased alpha power during visual creativity compared to baseline, but comparisons of visual creativity to non‐rest control tasks revealed inconsistent findings.ConclusionsThe findings are consistent with suggested contributions to visual creativity of prefrontally mediated inhibition, evaluation, and working memory, as well as visual imagery processes. Findings are discussed in relation to prominent theories of the neural basis of creativity.

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Subcortical roles in lexical task processing: Inferences from thalamic and subthalamic event‐related potentials

Tiedt

Ehlen

Krugel

et al. 2016

Human Brain Mapping

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Subcortical functions for language capacities are poorly defined, but may be investigated in the context of deep brain stimulation. Here, we studied event-related potentials recorded from electrodes in the subthalamic nucleus (STN) and the thalamic ventral intermediate nucleus (VIM) together with surface-EEG. Participants completed a lexical decision task (LDT), which required the differentiation of acoustically presented words from pseudo-words by button press. Target stimuli were preceded by prime-words. In recordings from VIM, a slow potential shift apparent at the lower electrode contacts persisted during target stimulus presentation (equally for words and pseudo-words). In contrast, recordings from STN electrodes showed a short local activation on prime-words but not target-stimuli. In both depth-recording regions, further components related to contralateral motor responses to target words were evident. On scalp level, mid-central activations on (pseudo)lexical stimuli were obtained, in line with the expression of N400 potentials. The prolonged activity recorded from VIM, exclusively accompanying the relevant LDT phase, is in line with the idea of thalamic "selective engagement" for supporting the realization of the behavioral focus demanded by the task. In contrast, the phasic prime related activity rather indicates "procedural" STN functions, for example, for trial sequencing or readiness inhibition of prepared target reactions. Hum Brain Mapp 38:370-383, 2017. © 2016 Wiley Periodicals, Inc.

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Involvement of the mediodorsal thalamic nucleus in mediating recollection and familiarity

Cited by 73 publications

References 33 publications

Unraveling the contributions of the diencephalon to recognition memory: A review

Unraveling the contributions of the diencephalon to recognition memory: A review

Functional neuroimaging of visual creativity: a systematic review and meta‐analysis

Subcortical roles in lexical task processing: Inferences from thalamic and subthalamic event‐related potentials

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