Involvement of the ganglion cholinergic receptors in gonadotropin-releasing hormone, catecholamines, and progesterone release in the rat ovary

Daneri, Cristina; Orozco, Adriana Vega; Bronzi, Daniela; Mohn, Claudia; Rastrilla, Ana María; Sosa, Zulema

doi:10.1016/j.fertnstert.2013.02.037

Cited by 15 publications

(8 citation statements)

References 40 publications

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“…As mentioned previously, these results may be related to the ovarian structural and functional differences between PE and DI and to the different neurotransmitters that are released via this neural pathway (ONP). The main neurotransmitters are norepinephrine, neuropeptide Y and substance P . This is in agreement with other reports that demonstrated that in rats, an i.c.v injection of epinephrine modifies, during a short period, the concentration of P4 in the ovarian vein during DI and DII …”

Section: Discussionsupporting

confidence: 92%

“Rapid actions of the neurosteroid allopregnanolone on ovarian and hypothalamic steroidogenesis: Central and peripheral modulation”

Cáceres

Orozco

Cabrera

et al. 2020

J Neuroendocrinology

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The present study aimed to determine whether an i.c.v. administration of allopregnanolone (ALLO) rapidly modifies the hypothalamic and ovarian 3β‐hydroxysteroid dehydrogenase (3β‐HSD) enzymatic activity and gene expression in in vivo and ex vivo systems in pro‐oestrus (PE) and dioestrus I (DI) rats. Animals were injected with vehicle, ALLO, bicuculline or bicuculline plus ALLO and were then killed. In the in vivo experiment, the hypothalamus, ovaries and serum were extracted and analysed. In the ex vivo experiment, the superior mesenteric ganglion ‐ ovarian nerve plexus ‐ ovary system was extracted and incubated during 120 minutes at 37 ºC. The serum and ovarian compartment fluids were used to determine progesterone by radioimmunoanalysis. In the in vivo experiments, ALLO caused a decrease in hypothalamic and ovarian 3β‐HSD enzymatic activity during PE. During DI, ALLO increased hypothalamic and ovarian 3β‐HSD activity and gene expression. The ovarian 3β‐HSD activity increased in both stages in the ex vivo system; gene expression increased only during DI. ALLO induced an increase in serum progesterone only in D1 and in the ovarian incubation liquids in both stages. All findings were reversed by an injection of bicuculline before ALLO. Ovarian steroidogenic changes could be attributed to signals coming from ganglion neurones, which are affected by the acute central neurosteroid stimulation. The i.c.v. administration of ALLO via the GABAergic system altered 3β‐HSD activity and gene expression, modulating the neuroendocrine axis. The present study reveals the action that ALLO exerts on the GABAA receptor in both the central and peripheral nervous system and its relationship with hormonal variations. ALLO is involved in the “fine tuning” of neurosecretory functions as a potent modulator of reproductive processes in female rats.

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Section: Discussionsupporting

confidence: 92%

“Rapid actions of the neurosteroid allopregnanolone on ovarian and hypothalamic steroidogenesis: Central and peripheral modulation”

Cáceres

Orozco

Cabrera

et al. 2020

J Neuroendocrinology

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“…In previous works, we have demonstrated that when the ovary alone is incubated without ganglionic influence, the control values of P 4 are higher than the control values when using the ex vivo system, where the sympathetic nerves are present [3,21]. In the ovary incubations, all those inhibitory neurotransmitters released from the ganglion are not present, and the ovary remains in contact with some neurotransmitters synthesized in the ovary such as catecholamines, considered as intraovarian regulators [26,27], which explains why the control values are higher.…”

Section: Discussionmentioning

confidence: 90%

“…It is important to emphasize that the decrease of ovarian P 4 in the experimental groups when adding NA in ganglion might be due to the liberation of different neurotransmitters, such as neuropeptide Y(NPY), nitric oxide NO, GnRH, GABA [3,21,25,26] and NA, from the SON to the ovary.…”

Section: Discussionmentioning

confidence: 99%

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Noradrenaline modulates the presence of gonadotropin-releasing hormone in ovary. The importance of its interrelation on the ovarian steroidogenesis and apoptosis on dioestrus II in rat.

Bronzi

Orozco

Rodríguez

et al. 2015

The Journal of Steroid Biochemistry and Molecular Biology

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“…It has been reported that under physiological conditions, ACh acting by muscarinic receptor modulates the ovarian blood flow (Dynarowicz and Dzięgielewski 1987), the follicular development and steroidogenesis (Delgado et al 2010; Daneri et al 2013) as well as takes part in the ovulation (Walles et al 1976). In addition, NO (Masuda et al 2001; Barszczewska and Jaroszewski 2004), VIP (Miyamoto et al 1993; Hulshof et al 1994) and SOM (Panconesi et al 1987; Andreani et al 1995) may participate in the ovarian blood flow and/or steroidogenesis.…”

Section: Discussionmentioning

confidence: 99%

Changes in the Cholinergic Innervation Pattern of Porcine Ovaries with Cysts Induced by Dexamethasone Administration

2014

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We revealed earlier that induction of ovarian cysts in gilts by dexamethasone phosphate disodium salt (DXM) administration from the follicular phase of the estrous cycle (EC) changed the cholinergic innervation of the gonad. In the present study, the innervation of porcine ovaries by vesicular acetylcholine transporter (VAChT)-, neuronal nitric oxide synthase (nNOS)-, vasoactive intestinal peptide (VIP)- and somatostatin (SOM)-immunoreactive (IR) fibres, after induction of cystic changes from the middle luteal phase of the EC, was determined. The cystic changes were induced by DXM injections from days 7 to 21 of the EC, and 11 days later, the ovaries were collected. In the cystic ovaries, VAChT-, nNOS- and SOM-IR fibres were found around cysts and small tertiary follicles; nNOS-IR and also VAChT-IR fibres were observed near secondary follicles and veins; and VAChT- and nNOS-IR fibres were not found around cortical arteries. The number of VIP-IR fibres increased near the cysts and within the ground plexus, while the number of VAChT-IR fibres decreased within the medullar part of this structure. Thus, our study showed changes in the cholinergic innervation pattern of the porcine cystic ovaries induced from the middle phase of the cycle and confirmed that cystic ovary innervation depends partly on the phase of the EC in which the induction of cysts was started.

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Involvement of the ganglion cholinergic receptors in gonadotropin-releasing hormone, catecholamines, and progesterone release in the rat ovary

Cited by 15 publications

References 40 publications

“Rapid actions of the neurosteroid allopregnanolone on ovarian and hypothalamic steroidogenesis: Central and peripheral modulation”

“Rapid actions of the neurosteroid allopregnanolone on ovarian and hypothalamic steroidogenesis: Central and peripheral modulation”

Noradrenaline modulates the presence of gonadotropin-releasing hormone in ovary. The importance of its interrelation on the ovarian steroidogenesis and apoptosis on dioestrus II in rat.

Changes in the Cholinergic Innervation Pattern of Porcine Ovaries with Cysts Induced by Dexamethasone Administration

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