Involvement of the Chromosomal Translocation t(11;18) in Some Mucosa-Associated Lymphoid Tissue Lymphomas and Diffuse Large B-Cell Lymphomas of the Ocular AdnexaEvidence from Multiplex Reverse Transcriptase-Polymerase Chain Reaction and Fluorescence In Situ Hybridization on Using Formalin-Fixed, Paraffin-Embedded Specimens

Takada, Shinichi; Yoshino, Tadashi; Taniwaki, Masafumi; Nakamura, Naoya; Nakamine, Hirokazu; Oshima, Koichi; Sadahira, Yoshito; Inagaki, Hiroshi; Akagi, Tadaatsu

doi:10.1097/01.mp.0000067421.92575.6e

Cited by 49 publications

(47 citation statements)

References 21 publications

(12 reference statements)

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“…Nevertheless, MALT lymphomas arising at sites other than the gastrointestinal tract display some specific morphological and molecular features. 6,10 This has prompted us to characterize a large series of MALT lymphomas arising in the ocular adnexa with reference to a selected number of molecules that could provide information about the pathogenesis and biological predictors of this disease.…”

Section: Discussionmentioning

confidence: 99%

“…22,24,31,33,34 In particular, the t(11;18) is reported as occurring in MALT lymphomas arising in the ocular adnexa at frequencies between 2.7 and 20%. 10,33,34 The different incidence of this and other translocations in MALT lymphomas from distinct anatomical sites is probably linked to specific prelymphomatous conditions that lead to neoplastic transformation. Another translocation involving MALT1 and IgH genes, t(14;18) (q32;q21) has recently been described as occurring more frequently at sites considered to have a low incidence of t(11;18), such as skin and orbit.…”

Section: Discussionmentioning

confidence: 99%

“…7,8 In general, MALT lymphomas at different extranodal locations share some common morphological, phenotypic and molecular features, which has led to the establishment of gastric MALT lymphoma as the prototype for the definition of the features of MALT lymphoma at different sites. 9,10 Nevertheless, there is increasing evidence to suggest that cases diagnosed with MALT lymphomas arising at different sites differ in the presence of infectious specific antigens-Helicobacter, Campylobacter, Borrelia, Chlamydia-promoting lymphoid cell proliferation, and in the frequency of chromosomal translocations such as t(11;18)(q21;q21), or the newly described t(14;18)(q32;q21) and t(3;14) (p14.1;q32). [10][11][12] As in the case of other extranodal lymphomas, most MALT lymphomas arising in the ocular adnexa have an indolent course with a favorable prognosis; 1,2 previous reports have demonstrated low local aggressivity with a reasonably good possibility of relapse control by radiotherapy.…”

mentioning

confidence: 99%

“…9,10 Nevertheless, there is increasing evidence to suggest that cases diagnosed with MALT lymphomas arising at different sites differ in the presence of infectious specific antigens-Helicobacter, Campylobacter, Borrelia, Chlamydia-promoting lymphoid cell proliferation, and in the frequency of chromosomal translocations such as t(11;18)(q21;q21), or the newly described t(14;18)(q32;q21) and t(3;14) (p14.1;q32). [10][11][12] As in the case of other extranodal lymphomas, most MALT lymphomas arising in the ocular adnexa have an indolent course with a favorable prognosis; 1,2 previous reports have demonstrated low local aggressivity with a reasonably good possibility of relapse control by radiotherapy. 13 This is in keeping with the findings from a large series of MALT lymphomas, which showed that the efficacy of treatment varied accordingly with the site, stage, and clinical status of patients.…”

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confidence: 99%

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Nuclear bcl10 expression characterizes a group of ocular adnexa MALT lymphomas with shorter failure-free survival

Franco

Camacho

Caleo³

et al. 2006

Modern Pathology

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Ocular adnexa B-cell lymphomas are a relatively rare group of extranodal lymphomas, marginal-zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT lymphomas) being the most frequent type at this location. As with other nongastrointestinal MALT lymphomas, ocular adnexa MALT lymphomas have distinct characteristics from those of the gastric MALT model, implying specific pathogenic events, which could be of interest in the prediction of clinical behavior and the choice between therapeutic options. In a series of 39 cases of ocular adnexa MALT lymphomas, studied using a tissue microarray, we observed that the most frequent alteration was related to apoptosis regulation. Thus, caspase 3 activity was completely abolished, and phosphorylated IjBa, a marker of NF-jB activation, showed increased expression, while cases with an increased number of large cells displayed increased expression of survivin and other cell-cycle-related proteins, such as cyclin A, cyclin E and Ki67, and p16 expression was reduced. There were no occurrences of t(11;18)(q21,q21), while 5/37 cases exhibited t(14;18)(q32;q21). Aberrant nuclear expression of bcl10 was observed in 11 cases, independently of the presence of translocations, and was significantly associated with phosphorylated IjBa expression and a reduced TdT-mediated biotin-dUTP nicked-end labeling apoptotic index. Moreover, patients with tumoral bcl10 nuclear expression showed shorter failure-free survival.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Nuclear bcl10 expression characterizes a group of ocular adnexa MALT lymphomas with shorter failure-free survival

Franco

Camacho

Caleo³

et al. 2006

Modern Pathology

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“…We examined FISH directly on paraffin-embedded tissue sections and detected split signal of BCL2 gene as descried earlier. 13 …”

Section: Fluorescence In Situ Hybridizationmentioning

confidence: 99%

Duodenal and nodal follicular lymphomas are distinct: the former lacks activation-induced cytidine deaminase and follicular dendritic cells despite ongoing somatic hypermutations

et al. 2009

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Although most follicular lymphomas are believed to be of nodal origin, they sometimes originate from the duodenum. We have reported that the latter differ from nodal follicular lymphomas in having lower clinical stages and uniformly low histological grades, along with variable region of immunoglobulin heavy chain gene (VH) usage that is more similar to mucosa-associated lymphoid tissue (MALT) lymphomas. Little is known, however, about whether they possess other characteristics of nodal follicular lymphomas, particularly ongoing mutations with follicular dendritic cells. We examined 17 cases for which PCR identified the monoclonal bands of the immunoglobulin gene. The duodenal cases showed ongoing mutations, but they lacked activationinduced cytidine deaminase (AID) expression, a statistically significant difference from the nodal cases (Po0.001), and their follicular dendritic cell networks were disrupted. Moreover, not only were VH deviations observed but also they used very restricted VH genes. Although the mechanisms of ongoing mutation without AID and follicular dendritic cell were not clarified, restricted VH usage strongly suggested that antigen stimulation was involved, and that was similar to MALT lymphomas. In conclusion, duodenal follicular lymphomas were shown to be unique, in that they had ongoing hypermutations such as nodal cases, but the mechanisms involved in the hypermutation were quite different; furthermore, restricted VH usage suggested a strong similarity to the antigen-dependent origin of MALT lymphomas.

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A novel fusion of theMALT1 gene and the microtubule-associated protein 4 (MAP4) gene occurs in diffuse large B-cell lymphoma

Penas

Kawadler

Siebert

et al. 2006

Genes Chromosom. Cancer

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Rearrangements of the MALT1 gene by the t(11;18)(q21;q21) and t(14;18)(q32;q21) are the most frequent structural chromosomal abnormalities in MALT lymphomas. These translocations lead to fusions of BIRC3-MALT1 and IGH-MALT1 respectively, and activate the NF-kappaB pathway. Among 122 diffuse large B-cell lymphomas and 28 Burkitt's lymphomas screened by interphase FISH, we found two cases with a break within MALT1, but without a t(11;18) or a t(14;18). Molecular genetic analyses in one of these cases revealed a novel "in frame" fusion of exon 9 of MALT1 and exon 9 of the microtubule-associated protein 4 (MAP4) gene. The translocation was accompanied by a deletion of MALT1 sequences distal to the breakpoint including the caspase-like domain, which is essential for activation of NF-kappaB. As a result of the deletion, the reciprocal 5'MAP4-3'MALT1 transcript was not present, demonstrating that the 5'MALT1-3'MAP4 fusion represents the pathogenetically relevant transcript. Immunohistochemistry with amino-terminal and carboxy-terminal MALT1 antibodies, indicated a strong expression of the chimeric MALT1-MAP4 protein. Moreover, NF-kappaB activation was not increased in this case as shown by the levels of IkappaBalpha phosphorylation and NEMO ubiquitination. Our data demonstrate that the pathogenetic consequences of the novel MALT1-MAP4 fusion are different from those of the known MALT1-associated chromosomal rearrangements and do not involve NF-kappaB activation.

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Cited by 49 publications

References 21 publications

Nuclear bcl10 expression characterizes a group of ocular adnexa MALT lymphomas with shorter failure-free survival

Nuclear bcl10 expression characterizes a group of ocular adnexa MALT lymphomas with shorter failure-free survival

Duodenal and nodal follicular lymphomas are distinct: the former lacks activation-induced cytidine deaminase and follicular dendritic cells despite ongoing somatic hypermutations

A novel fusion of theMALT1 gene and the microtubule-associated protein 4 (MAP4) gene occurs in diffuse large B-cell lymphoma

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