Involvement of the ABCB1 C3435T Variant but Not the MTHFR C677T or MTHFR A1298C Variant in High-Dose Methotrexate-Induced Toxicity in Pediatric Acute Lymphoblastic Leukemia Patients in China
Qie Guo,
Jia-Lin Sun,
Ran Li
et al.
Abstract:Purpose
It remains unclear whether the
MTHFR C677T, MTHFR A1298C
and
ABCB1 C3435T
genetic variants are associated with methotrexate (MTX) elimination delay and high-dose MTX (HD-MTX) toxicities in the treatment of pediatric acute lymphoblastic leukemia (ALL). The aim of our study was to analyze the potential predictive role of
MTHFR C677T, MTHFR A1298C
and
ABCB1 C3435T
in toxicities and the … Show more
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