Involvement of Secretin in the Control of Cell Survival and Synaptic Plasticity in the Central Nervous System

Wang, Lei; Zhang, Li

doi:10.3389/fnins.2020.00387

Cited by 4 publications

(2 citation statements)

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“…Secretin is a hormone which is originally found to be released from the enteroendocrine S-cells in the duodenum in response to intestinal acidification and participates in food digestion ( 40 ). Some additional effects of secretin on distant organs have been previously discovered, such as promoting lipolysis in WAT, nourishing the nervous system, and regulating renal reabsorption ( 40 – 43 ). Inspiringly, it has been demonstrated to play a role in the regulation of energy metabolism through the binding to its receptors in brown adipocytes, which in turn rouses BAT activation and stimulates lipolysis in mice ( 44 ).…”

Section: Recent Progress In Targeting Human Brown/beige Adipose Tissu...mentioning

confidence: 99%

Latest Advancements on Combating Obesity by Targeting Human Brown/Beige Adipose Tissues

Pan

Chen

2022

Front. Endocrinol.

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Obesity is defined as overaccumulation of white adipose tissue in the body, mainly under the skin (subcutaneous adiposity) or in the abdominal cavity (visceral adiposity). It could be the origin of various metabolic disorders including hypertension, hyperlipidemia, type 2 diabetes, cardiovascular diseases etc. Active adipose tissue was discovered in humans through 18F-fluorodeoxyglucose Positron Emission Tomography coupled with Computer Tomography (18F FDG-PET/CT), which was initially performed for tumor scanning. Since human active adipose tissue is probably composed of brown and beige adipose tissues and they burn white adipose tissue to generate heat, targeting human brown/beige adipose tissue to induce their thermogenic function is considered significant to combat obesity. In this review, we describe the latest advancements on promising therapeutic strategies to combat obesity by targeting human thermogenic adipose tissues to achieve further metabolic balance in humans.

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Section: Recent Progress In Targeting Human Brown/beige Adipose Tissu...mentioning

confidence: 99%

Latest Advancements on Combating Obesity by Targeting Human Brown/Beige Adipose Tissues

Pan

Chen

2022

Front. Endocrinol.

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“…Secretin is primarily known for its role in regulating neurodevelopment and memory function via 4 effects on synaptic plasticity (Wang and Zhang, 2020). Synaptic plasticity, learning, and memory 4 specifically, secretin regulates GABAergic transmission to gonadotropin-releasing hormone-4 producing cells (Csillag et al, 2019), as well as affecting the firing rate of over 50% of examined 4 paraventricular hypothalamus neurons in rat in vivo studies (Chen et al, 2013).…”

Section: Differentially Expressed Genes and A Regulatory Role For The Ventromedial Hypothalamusmentioning

confidence: 99%

Social boldness correlates with brain gene expression in male green anoles

Kabelik

Julien

Ramirez

et al. 2021

Preprint

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Within populations, some individuals tend to exhibit a bold or shy social behavior phenotype relative to the mean. The neural underpinnings of these differing phenotypes – also described as syndromes, personalities, and coping styles – is an area of ongoing investigation. Although a social decision-making network has been described across vertebrate taxa, most studies examining activity within this network do so in relation to exhibited differences in behavioral expression. Our study instead focuses on constitutive gene expression in bold and shy individuals by isolating baseline gene expression profiles that influence social boldness predisposition, rather than those reflecting the results of social interaction and behavioral execution. We performed this study on male green anole lizards (Anolis carolinensis), an established model organism for behavioral research, which provides a crucial comparison group to investigations of birds and mammals. After identifying subjects as bold or shy through repeated reproductive and agonistic behavior testing, we used RNA sequencing to compare gene expression profiles between these groups within various forebrain, midbrain, and hindbrain regions. The ventromedial hypothalamus had the largest group differences in gene expression, with bold males having increased expression of calcium channels and neuroendocrine receptor genes compared to shy males. Conversely, shy males express more integrin alpha-10 in the majority of examined regions. There were no significant group differences in physiology or hormone levels. Our results highlight the ventromedial hypothalamus as an important center of behavioral differences across individuals and provide novel candidates for investigation into the regulation of individual variation in social behavior phenotype.

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