2006
DOI: 10.1073/pnas.0605146103
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Involvement of Rad18 in somatic hypermutation

Abstract: Somatic hypermutation of Ig genes is initiated by transcriptioncoupled cytidine deamination in Ig loci. Error-prone processing of the resultant DNA lesions is thought to cause extensive mutagenesis, but it is presently an enigma how and why error-prone rather than error-free repair pathways are recruited. During DNA replication, recruitment of error-prone translesion polymerases may be mediated by Rad6͞Rad18-mediated ubiquitination of proliferating cell nuclear antigen, a major switchboard controlling the fide… Show more

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Cited by 31 publications
(32 citation statements)
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“…It remains to be determined whether human carriers of POLH [31]. RAD 18 is an E3 ubiquitin ligase which, together with RAD6, monoubiquitinates PCNA on stalled replication forks and has been implicated in SHM of Ig genes in chicken DT40 cells [32,33]. REV1 has been shown to interact with multiple Y-family DNA polymerases [34] and contribute to the generation of C to G and G to C transversions in Ig genes in mice [10,11].…”
Section: Discussionmentioning
confidence: 99%
“…It remains to be determined whether human carriers of POLH [31]. RAD 18 is an E3 ubiquitin ligase which, together with RAD6, monoubiquitinates PCNA on stalled replication forks and has been implicated in SHM of Ig genes in chicken DT40 cells [32,33]. REV1 has been shown to interact with multiple Y-family DNA polymerases [34] and contribute to the generation of C to G and G to C transversions in Ig genes in mice [10,11].…”
Section: Discussionmentioning
confidence: 99%
“…On the basis of previous work with yeast (12), human cells (11), and DT40 chicken cells (16,17,19), we examined whether the K164R mutation would interfere with the second phase of SHM that is responsible for the mutations in A:T residues, which have *Theoretical maximum number of unique mutations: number of sites ϫ the number of mice in the category ϫ 3 (because 3 possible substitutions can occur at each site). † Observed number of unique mutations: within each mouse, identical mutations were counted once.…”
Section: Discussionmentioning
confidence: 99%
“…The monoubiquitylation of PCNA is regulated by a complex mechanism that involves the E2 and E3 ubiquitin ligases, RAD6 and RAD18, and deubiquitylation primarily by USP1 (12,15,16). Recent studies in the DT40 chicken B cell line (16,17) suggest that the recruitment and activation of Pol to the Ig V regions is mediated by PCNA that is monoubiquitylated at residue K164.…”
mentioning
confidence: 99%
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