2003
DOI: 10.1038/sj.leu.2402824
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Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy

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Cited by 1,059 publications
(838 citation statements)
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References 156 publications
(186 reference statements)
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“…Activation of the PI3K/Akt signalling pathway The PI3K/Akt pathway is a signalling network that promotes cell survival and proliferation, and plays a role in oncogenic transformation and in prevention of apoptosis (Lin et al, 1999;Chang et al, 2003). Our microarray experiments previously identify components of the PI3K/Akt/GSK-3b as upregulated in MSTN-null mice.…”
Section: Discussionmentioning
confidence: 85%
“…Activation of the PI3K/Akt signalling pathway The PI3K/Akt pathway is a signalling network that promotes cell survival and proliferation, and plays a role in oncogenic transformation and in prevention of apoptosis (Lin et al, 1999;Chang et al, 2003). Our microarray experiments previously identify components of the PI3K/Akt/GSK-3b as upregulated in MSTN-null mice.…”
Section: Discussionmentioning
confidence: 85%
“…23 PI3K is activated by the interaction of the p85 subunit with phosphorylated tyrosine residues on activated growth factor receptors including the EGFR. 24 To study whether the reduced basal and EGF-stimulated PI3K activity in PC3-AR cells is due to an impairment of PI3K-EGFR interaction, we immunpreciptated PI3K from PC3-Neo and -AR cells using an anti-p110 PI3K antibody and evaluated coimmunoprecipitation with EGFR in both cell lines.…”
Section: Egf-induced Activation Of Pi3k Is Reduced In Pc3-ar Cellsmentioning
confidence: 99%
“…PI3K/ Akt signaling thus plays a major role in oncogenesis and it is not surprising that deregulations of components within this pathway are targets for cancer treatment (Chang et al, 2003;Osaki et al, 2004;Hennessy et al, 2005).…”
Section: Introductionmentioning
confidence: 99%