Involvement of peripheral and central catecholamine systems in neural-immune interactions

Livnat, Shmuel; Felten, Suzanne Y.; Carlson, Sonia L.; Bellinger, Denise L.; Felten, David L.

doi:10.1016/0165-5728(85)90031-1

Cited by 279 publications

(96 citation statements)

References 84 publications

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“…Of note, immune responses to antigen and mitogen are dramatically different in chemically sympathectomized mice. The immune response to mitogens seems to be depressed, whereas the response to antigen is enhanced in 6-OHDA-treated mice (6,18). The seemingly divergent results are most likely due to variations in mouse strain and type of immune stimuli used.…”

mentioning

confidence: 80%

“…Chemical sympathectomy decreases bacterial loads and increases innate immune responses to Listeria monocytogenes (16). However, 6-OHDA-treated mice have also exhibited decreased antibody responses to sheep red blood cells (17), although the extent of inhibition varies between inbred mouse strains (6). Of note, immune responses to antigen and mitogen are dramatically different in chemically sympathectomized mice.…”

mentioning

confidence: 96%

“…The SNS consists of adrenergic nerve fibers that exit the spinal cord to form para-spinal ganglia that innervate peripheral organs, including all primary and secondary lymphoid tissues (3)(4)(5). Studies of splenic architecture identified adrenergic nerve fibers in the capsule, traberculae, and white pulp (6). The close proximity of adrenergic fibers to immune cells in lymphoid organs suggests that the SNS may regulate immune responses.…”

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confidence: 99%

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Sympathetic nervous system control of anti-influenza CD8⁺T cell responses

Grebe

Hickman

Irvine

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

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Despite the longstanding appreciation of communication between the nervous and the immune systems, the nature and significance of these interactions to immunity remain enigmatic. Here, we show that 6-hydroxydopamine-mediated ablation of the mouse peripheral sympathetic nervous system increases primary CD8 ؉ T cell responses to viral and cellular antigens presented by direct priming or crosspriming. The sympathetic nervous system also suppresses antiviral CD4 ؉ T cell responses, but this is not required for suppressing CD8 ؉ T cell responses. Adoptive transfer experiments indicate that enhanced CD8 ؉ responses do not result from permanent alterations in CD8 ؉ T cell function in sympathectomized mice. Rather, additional findings suggest that the sympathetic nervous system tempers the capacity of antigen-presenting cells to activate naïve CD8 ؉ T cells. We also show that antiviral CD8 ؉ T cell responses are enhanced by administration of a ␤2 (but not ␤1 or ␣) adrenergic antagonist. These findings demonstrate a critical role for the sympathetic nervous system in limiting CD8 ؉ T cell responses and indicate that CD8 ؉ T cell responses may be altered in patients using ␤-blockers, one of the most widely prescribed classes of drugs.antigen presentation ͉ vaccine ͉ cross-priming ͉ direct-priming ͉ dendritic cell

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confidence: 80%

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confidence: 96%

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confidence: 99%

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Sympathetic nervous system control of anti-influenza CD8⁺T cell responses

Grebe

Hickman

Irvine

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

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“…Conversely, electrical stimulation of hypothalamic regions has been reported to augment several immune parameters (Korneva, 1967). With regard to the autonomic nervous system, chemical destruction with 6-hydroxydopamine can impair some aspects of immune function (Livnat, Felten, Carlson, Bellinger, & Felten, 1985). The point is that destruction or stimulation of neural pathways that are connected to the immune system do, in fact, alter the function of the immune system, and so the connection between the CNS is of real significance, not merely an anatomic curiosity.…”

Section: Connections From the Central Nervous System To The Immune Symentioning

confidence: 99%

Psychoneuroimmunology: The interface between behavior, brain, and immunity.

Maier¹,

Watkins²,

Fleshner³

1994

American Psychologist

319

168

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Psychoneuroimmunology is the study of interactions between behavior, the brain, and the immune system. This article is designed to provide an overview of this new field for the general psychologist. The existence of bidirectional communication pathways between the brain and the immune system and the implications of this network for behavior are emphasized. Implications are that behavioralpsychological processes ought to be capable of altering immune function and that events that occur as part of immune responses should modulate behavior. Evidence for influences in both of these directions is reviewed. The discussion of psychological modulation of immunity focuses on classical conditioning and stress, whereas that of immune modification of behavior highlights behavioral effects produced by substances released by the immune system. Finally, the adaptive role that such changes might play is considered. Lyle E. Bourne served as action editor for this article.

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“…Moreover, evidence indicates the existence of neural-mediated immunomodulatory mechanisms involving the sympathetic and parasympathetic innervation of primary and secondary lymphoid organs. 24 These mechanisms may modulate MNL G proteins. Altered autonomic functions occur in AN and, to a lesser degree, in BN; 25,26 thus, MNL G protein alterations in our anorexic and bulimic patients may reflect secondary influences of altered autonomic innervation of lymphoid organs.…”

Section: Discussionmentioning

confidence: 99%

Altered immunoreactive levels of G proteins in peripheral mononuclear cells of patients with anorexia nervosa and bulimia nervosa

et al. 2003

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Alterations of cellular G proteins have been implicated in the pathophysiology of some psychiatric disorders. So far, no study assessed G protein function in anorexia nervosa (AN) and bulimia nervosa (BN). Therefore, we measured immunoreactive levels of G as , G ai , G aq/11 and G b protein subunits in mononuclear leukocytes of 71 drug-free women, including 25 subjects with AN, 26 individuals with BN and 20 healthy controls. As compared to healthy women, anorexic patients exhibited significantly increased levels of G ai and G b proteins, while bulimic patients had significantly increased levels of G as , G ai and G b proteins. Immunoreactive levels of peripheral G protein subunits were not significantly correlated with demographic or nutritional parameters. These findings, although obtained in peripheral blood cells, may suggest a derangement of G protein-mediated signal transduction in the pathophysiology of eating disorders.

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Involvement of peripheral and central catecholamine systems in neural-immune interactions

Cited by 279 publications

References 84 publications

Sympathetic nervous system control of anti-influenza CD8⁺T cell responses

Sympathetic nervous system control of anti-influenza CD8⁺T cell responses

Psychoneuroimmunology: The interface between behavior, brain, and immunity.

Altered immunoreactive levels of G proteins in peripheral mononuclear cells of patients with anorexia nervosa and bulimia nervosa

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Involvement of peripheral and central catecholamine systems in neural-immune interactions

Cited by 279 publications

References 84 publications

Sympathetic nervous system control of anti-influenza CD8+T cell responses

Sympathetic nervous system control of anti-influenza CD8+T cell responses

Psychoneuroimmunology: The interface between behavior, brain, and immunity.

Altered immunoreactive levels of G proteins in peripheral mononuclear cells of patients with anorexia nervosa and bulimia nervosa

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Sympathetic nervous system control of anti-influenza CD8⁺T cell responses

Sympathetic nervous system control of anti-influenza CD8⁺T cell responses