Involvement of oxytocin and GABA in consolation behavior elicited by socially defeated individuals in mandarin voles

Li, Lai-Fu; Yuan, Wei; He, Zhixue; Wang, Limin; Jing, Xiao-Yuan; Zhang, Jing; Yang, Yang; Guo, Qianqian; Zhang, Xueni; Cai, Wenqi; Hou, Wenjuan; Jia, Rui; Tai, Fadao

doi:10.1016/j.psyneuen.2018.12.238

Cited by 41 publications

(54 citation statements)

References 48 publications

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“…60 These findings suggest that activation of oxytocin neurones by social support reduces stress responses. 63 Oxytocin has also been shown to have analgesic effects. 62 Oxytocin receptor-dependent consolation behaviour toward distressed partners has also been reported in mandarin voles.…”

Section: Roles Of Oxytocin In Stress Responses: Attenuation or Facimentioning

confidence: 99%

“…62,63 Consolation reduces anxiety-related behaviour and activity of the hypothalamo-pituitary adrenal axis in both givers and receivers of consolation. 62,63 Consolation reduces anxiety-related behaviour and activity of the hypothalamo-pituitary adrenal axis in both givers and receivers of consolation.…”

Section: Medial Prefrontal Cortexmentioning

confidence: 99%

“…62 Oxytocin receptor-dependent consolation behaviour toward distressed partners has also been reported in mandarin voles. 63 Oxytocin has also been shown to have analgesic effects. 64 Oxytocin neurones are activated after noxious stimuli 10 and oxytocin acts on multiple sites, including the spinal cord and dorsal root ganglia, to induce analgesia.…”

Section: Roles Of Oxytocin In Stress Responses: Attenuation or Facimentioning

confidence: 99%

“…Consolation behaviour of male prairie voles and mandarin voles toward distressed female partners has been shown to be mediated by the oxytocin receptor in the anterior cingulate. 62,63 Consolation reduces anxiety-related behaviour and activity of the hypothalamo-pituitary adrenal axis in both givers and receivers of consolation.…”

Section: Medial Prefrontal Cortexmentioning

confidence: 99%

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Role of oxytocin in the control of stress and food intake

Onaka

Takayanagi

2019

J Neuroendocrinology

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Oxytocin neurones in the hypothalamus are activated by stressful stimuli and food intake. The oxytocin receptor is located in various brain regions, including the sensory information‐processing cerebral cortex; the cognitive information‐processing prefrontal cortex; reward‐related regions such as the ventral tegmental areas, nucleus accumbens and raphe nucleus; stress‐related areas such as the amygdala, hippocampus, ventrolateral part of the ventromedial hypothalamus and ventrolateral periaqueductal gray; homeostasis‐controlling hypothalamus; and the dorsal motor complex controlling intestinal functions. Oxytocin affects behavioural and neuroendocrine stress responses and terminates food intake by acting on the metabolic or nutritional homeostasis system, modulating emotional processing, reducing reward values of food intake, and facilitating sensory and cognitive processing via multiple brain regions. Oxytocin also plays a role in interactive actions between stress and food intake and contributes to adaptive active coping behaviours.

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Section: Roles Of Oxytocin In Stress Responses: Attenuation or Facimentioning

confidence: 99%

Section: Medial Prefrontal Cortexmentioning

confidence: 99%

Section: Roles Of Oxytocin In Stress Responses: Attenuation or Facimentioning

confidence: 99%

Section: Medial Prefrontal Cortexmentioning

confidence: 99%

See 2 more Smart Citations

Role of oxytocin in the control of stress and food intake

Onaka

Takayanagi

2019

J Neuroendocrinology

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“…Prairie voles also have a unique set of social behaviors significantly regulated by dopamine throughout the mesolimbic pathway and extended amygdala (Gobrogge and Wang, 2016;Northcutt and Lonstein, 2009). While the closely related Mandarin vole (Microtus mandarinus) has recently been used to model social defeat, a direct comparison of males and females has yet to be performed (Li et al, 2018;Wang et al, 2018). Additionally, recent Tickerhoof (Manuscript) 5 work in developing transgenic prairie voles has begun to examine the effects of developmental gene manipulation on prairie vole sociality (Horie et al, 2018), increasing the utility of this species in examining the neurobiology connecting stress and social behavior as more tools become available.…”

Section: Introductionmentioning

confidence: 99%

Regulation of defeat-induced social avoidance by medial amygdala DRD1 in male and female prairie voles

Tickerhoof

Hale

Smith

2019

Preprint

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Social interaction with unfamiliar individuals is necessary for species-preserving behaviors such as finding mates and establishing social groups. However, social conflict is a potential negative outcome to interaction with a stranger that can be distressing enough to cause an individual to later avoid interactions with other unfamiliar conspecifics. Unfortunately, stress research using a prominent model of social conflict, social defeat stress, has largely omitted female subjects. This has left a void in the literature regarding social strain on female stress biology and adequate comparison of the effect of sex in stress pathways. The prairie vole (Microtus ochrogaster) exhibits aggressive behavior in both sexes, making voles an attractive candidate to model social defeat in both sexes. This study sought to establish a model of social defeat stress in both male and female prairie voles, characterize behavioral changes in response to this stressor, and investigate the role of dopamine signaling in the response to social defeat stress. Defeated male and female prairie voles displayed social avoidance as well as an increase in expression of dopamine receptor D1 (DRD1) in the medial amygdala (MeA). Pharmacological manipulation of DRD1 signaling in the MeA revealed that increased DRD1 signaling is sufficient to induce a social avoidant state, and could be a necessary component in the defeat-induced social avoidance response. These findings provide the prairie vole as a model of social defeat in both sexes, and implicate the MeA in avoidance of unfamiliar conspecifics after a distressing social encounter.

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Mean Girls: Social Stress Models for Female Rodents

Kuske

Trainor

2021

Current Topics in Behavioral Neurosciences

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Involvement of oxytocin and GABA in consolation behavior elicited by socially defeated individuals in mandarin voles

Cited by 41 publications

References 48 publications

Role of oxytocin in the control of stress and food intake

Role of oxytocin in the control of stress and food intake

Regulation of defeat-induced social avoidance by medial amygdala DRD1 in male and female prairie voles

Mean Girls: Social Stress Models for Female Rodents

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