Involvement of oxidative stress in patients of gout and antioxidant effect of allopurinol

Acharya, Chetan R; Sharma, Abhinav K.; Kantharia, ND

doi:10.5455/ijmsph.2015.0310201435

Cited by 16 publications

(22 citation statements)

References 17 publications

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“…Serum levels of Superoxide dismutase and Glutathione peroxidase were statistically similar for cases and controls. This result differs from that of Chetan et al who found rates of Superoxide dismutase and Glutathione peroxidase significantly lower in subjects with an acute gout attack compared to healthy subjects (p < 0.01) [8]. This difference can be explained by several factors: 1) the status of patients who were newly diagnosed with gout in the study of Chetan and al unlike ours, where 73% of patients had an acute gout attack on chronic gout; 2) the racial differences of our study populations could influence the level of oxidative stress, genetics and eating habits being conditioned by racial origin, they play an important role in the pathogenesis of oxidative stress [9]; 3) when oxidative stress continues, there is a decrease in serum levels of Superoxide dismutase and Glutathione peroxidase which are antioxidants and are the first lines of the body's defense against oxidants.…”

Section: Discussioncontrasting

confidence: 99%

“…However, malondialdehyde levels were higher among cases compared to controls (p < 0.05). This result is similar to that found by Chetan et al in 2014 [8]. Malondialdehyde is an oxidant, which reflects lipid peroxidation; high levels of Malondialdehyde alone may reflect oxidative damages to lipids in patients with gout who have a metabolic syndrome.…”

Section: Discussionsupporting

confidence: 91%

“…Several experimental, epidemiological and clinical studies have shown that hyperuricemia is associated to the development of high blood pressure, type II diabetes, chronic kidney disease, cardiovascular and cerebrovascular events [5] [6] [7]. Although the relationship between these conditions and hyperuricemia is not clearly established, it appears that the oxidative stress would be common to the pathogenesis of these disorders [8]. Oxidative stress is an imbalance between the oxidant and antioxidant factors of the body in favour of the oxidizing factors with formation of free radicals and other active oxygenated species; these free radicals will be responsible for the cellular damage, leading to aging, increasing cardiovascular risk and promoting many ailments [9].…”

Section: Introductionmentioning

confidence: 99%

“…Oxidative stress is an imbalance between the oxidant and antioxidant factors of the body in favour of the oxidizing factors with formation of free radicals and other active oxygenated species; these free radicals will be responsible for the cellular damage, leading to aging, increasing cardiovascular risk and promoting many ailments [9]. Uric acid has been described in several studies in Caucasian and Indonesian populations as having an antioxidant but also a pro-oxidant effect [8] [10] [11]. The relationship between hyperuricemia, gout and oxidative stress is therefore not clearly established, so it appears important to evaluate the oxidative status of subjects with gout in order to contribute to the improvement of knowledge on the issue.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Oxidative Status of Patients with Gout Attack in a Cameroonian Urban Hospital

Nkeck¹,

Singwé–Ngandeu²,

Moor³

et al. 2017

OJRA

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Background: Gout is the leading cause of microcrystalline arthritis worldwide and the most common cause of arthritis in adult men. The prevalence of cardiovascular disease, type II diabetes and metabolic syndrome is high among gout patients; one of the current hypotheses that may explain this relationship is based on oxidative stress; however, few studies have sought to investigate this relationship. Objective: The aim of this study was to determine the oxidative status of patients with gout attack. Methods: We conducted a case-control study over a 4 months period at the Rheumatology service of the Yaoundé Central Hospital. Cases were patients with an acute gout attack and controls were healthy subjects matched for sex and age. We evaluated uricemia, serum levels of Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx), Catalase and Malondialdehyde (MDA). Oxidative stress was defined by an increase in MDA and/or a decrease in SOD, Catalase and GPx. Statistical analysis was performed by the S.P.S.S. 21.0 software. The Student's T-test was used to compare means; the significance threshold was 0.05. Results: Sixty subjects were recruited of which 30 with an acute gout attack and 30 healthy subjects. The mean ages of the cases and controls were respectively 58 ± 8 years and 57.6 ± 8 years. Uricemia was statistically higher in cases (81 ± 20 mg/L) compared to controls (47 ± 11 mg/L) (p < 0.001). MDA levels were higher among cases (1.37 ± 0.46 mmol/L) compared to controls (1.14 ± 0.39 mmol/L) (p < 0.05). There was no significant difference in serum levels of catalase, SOD and GPx between cases and controls. Conclusion: Patients with gout attack have an elevated serum level of malondialdehyde but their oxidative status seems similar to that of normal individuals.How to cite this paper: Nkeck, J.R., Singwé-Ngandeu, M., Moor, V.A., Chedjou,

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of Oxidative Status of Patients with Gout Attack in a Cameroonian Urban Hospital

Nkeck¹,

Singwé–Ngandeu²,

Moor³

et al. 2017

OJRA

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“…XO is a significant biological source of free radical generation and allopurinol, as an antioxidant, has direct and indirect antioxidant activity on these free radicals. Furthermore, it can scavenge free radicals such as hydroxyl radical and superoxide anion and numerous studies have shown these effects of allopurinol (5). Oxidative tissue damage after the ischemic diseases such as renal IRI (ischemia/reperfusion injury) is related to the XO and using allopurinol can reduce the renal ischemiainduced oxidative tissue damage (6).…”

Section: Introductionmentioning

confidence: 99%

An update on allopurinol and kidney failure; new trend for an old drug

Alirezaei¹,

Argani²,

Asgharpour³

et al. 2017

J Renal Inj Prev

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Findings of this review show that treatment with allopurinol as a purine inhibitor of xanthine oxidase enzyme can decrease oxidative stress and uric acid levels and may help to restore the endothelial function and slow down the progression of renal disorder to end stage renal disease. Allopurinol is an inhibitor of xanthine oxidase (XO) enzyme. This drug is a reducer of uric acid in the body and one of the golden drugs with worldwide administration. XO is an important biological source of free radical generation. Allopurinol as an antioxidant, has direct and indirect antioxidant activity on these free radicals such as hydroxyl radical and superoxide anion. The purpose of this paper is to determine the impact of allopurinol on some aspects of renal disturbances such as renal ischemia/reperfusion injury (IRI), nephrotoxicity and contrast-induced nephropathy (CIN). Please cite this paper as:

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Influence of Pinealectomy and Long-term Melatonin Administration on Inflammation and Oxidative Stress in Experimental Gouty Arthritis

et al. 2022

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Gout is an in ammatory arthritis characterized by the deposition of monosodium urate (MSU) crystals in the joints or soft tissue. MSU crystals are potent in ammation inducers. Melatonin (MLT) is a powerful endogenous anti-in ammatory agent and effective in reducing cellular damage. In the present study, possible underlying mechanisms associated with anti-in ammatory and anti-oxidative effects were investigated in rats with gouty arthritis and melatonin deprivation treated with MLT. Fifty-six rats were divided into seven groups: control, sham control, pinealectomy (PNX), MSU (On the 30th day, single dose 20 mg/ml, intraperitoneal), MSU+MLT (10 mg/kg/day for 30 days, intraperitoneal), MSU+PINX and MSU+PINX+MLT. PNX procedure was performed on the rst day of the study. As compared to the controls, the results showed that MSU administration caused signi cant increases in oxidative stress parameters (malondialdehyde and total oxidant status). Besides, signi cant decreases in antioxidant defense systems (glutathione, superoxide dismutase and total antioxidant status were observed. A statistically signi cant increase was found in the mean histopathological damage score in the groups that received MSU injection. It was found that histopathological changes were signi cantly reduced in the MSU+MLT group given MLT. In our study, it was determined that many histopathological changes, as well as swelling and temperature increase in the joint, which are markers of in ammation, were signi cantly reduced with MLT supplementation. These results suggest that melatonin ameliorates MSU-induced gout in the rat through inhibition of oxidative stress and proin ammatory cytokine production.

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Involvement of oxidative stress in patients of gout and antioxidant effect of allopurinol

Cited by 16 publications

References 17 publications

Evaluation of Oxidative Status of Patients with Gout Attack in a Cameroonian Urban Hospital

Evaluation of Oxidative Status of Patients with Gout Attack in a Cameroonian Urban Hospital

An update on allopurinol and kidney failure; new trend for an old drug

Influence of Pinealectomy and Long-term Melatonin Administration on Inflammation and Oxidative Stress in Experimental Gouty Arthritis

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