Involvement of oxidative stress in subacute toxicity induced by fumonisin B1 in broiler chicks

Poersch, A.B.; Trombetta, F.; Braga, Ana Cláudia Monteiro; Boeira, Silvana Peterini; Dilkin, Paulo; Mallmann, Carlos Augusto; Fighera, Michele Rechia; Royes, Luiz Fernando Freire; Oliveira, Mauro Schneider; Furian, Ana Flávia

doi:10.1016/j.vetmic.2014.08.020

Cited by 40 publications

(26 citation statements)

References 30 publications

(40 reference statements)

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“…In vitro studies conducted on several cell lines have suggested the possible role of oxidative stress on FB 1 -induced cytotoxicity and apoptosis (Bernabucci et al 2011;Domijan et al 2015;Ferrante et al 2002;Kang and Alexander 1996;Klaric et al 2007;Kouadio et al 2005;Mary et al 2012;Mobio et al 2003;Stockmann-Juvala et al 2004a, b). Similar results were also observed in mice (Abbes et al 2015), rats (Hassan et al 2014) and broiler chicks (Poersch et al 2014). Oxidative stress will occur in cells when the concentration of ROS exceeds the antioxidant capacity (Mishra et al 2014).…”

supporting

confidence: 76%

“…for 12 weeks decreased GSH content in the liver and kidney and down-regulated the gene expression of antioxidants enzymes such as GPX, SOD and CAT (Hassan et al 2014). When broiler chicks were administered the FB 1 diet (100 mg/kg) for 21 days, the hepatic CAT activity in the liver was significantly increased, showing that subacute exposure of FB 1 induced liver oxidative stress in broiler chicks (Poersch et al 2014). In SMC of male Wistar rats subchronically (90 days) fed with culture material containing 100 mg/kg of FB 1 , the CAT and SOD activities were increased in the poisoned animals, indicating the hypothesis of an oxidative stress-mediated genotoxicity induced by FB 1 (Theumer et al 2010).…”

Section: Alterations In Antioxidant Statusmentioning

confidence: 96%

“…resulted in a significant increase in MDA level in liver and kidney tissues (Hassan et al 2014). After feeding a diet contaminated with FB 1 (100 mg/kg) for 21 days, hepatic TBARS levels in male broiler chicks were also increased (Poersch et al 2014). Theumer et al (2010) reported that after exposure to experimental diets contaminated with a culture material containing 100 mg/kg of FB 1 for 90 days, the MDA levels were increased in SMC (Theumer et al 2010).…”

Section: Damage To Lipidsmentioning

confidence: 99%

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Fumonisins: oxidative stress-mediated toxicity and metabolism in vivo and in vitro

Wang

Wan

et al. 2015

Arch Toxicol

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Fumonisins (FBs) are widespread Fusarium toxins commonly found as corn contaminants. FBs could cause a variety of diseases in animals and humans, such as hepatotoxic, nephrotoxic, hepatocarcinogenic and cytotoxic effects in mammals. To date, almost no review has addressed the toxicity of FBs in relation to oxidative stress and their metabolism. The focus of this article is primarily intended to summarize the progress in research associated with oxidative stress as a plausible mechanism for FB-induced toxicity as well as the metabolism. The present review showed that studies have been carried out over the last three decades to elucidate the production of reactive oxygen species (ROS) and oxidative stress as a result of FBs treatment and have correlated them with various types of FBs toxicity, indicating that oxidative stress plays critical roles in the toxicity of FBs. The major metabolic pathways of FBs are hydrolysis, acylation and transamination. Ceramide synthase, carboxylesterase FumD and aminotransferase FumI could degrade FB1 and FB2. The cecal microbiota of pigs and alkaline processing such as nixtamalization can also transform FB1 into metabolites. Most of the metabolites of FB1 were less toxic than FB1, except its partial (pHFB1) metabolites. Further understanding of the role of oxidative stress in FB-induced toxicity will throw new light on the use of antioxidants, scavengers of ROS, as well as on the blind spots of metabolism and the metabolizing enzymes of FBs. The present review might contribute to reveal the toxicity of FBs and help to protect against their oxidative damage.

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supporting

confidence: 76%

Section: Alterations In Antioxidant Statusmentioning

confidence: 96%

Section: Damage To Lipidsmentioning

confidence: 99%

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Fumonisins: oxidative stress-mediated toxicity and metabolism in vivo and in vitro

Wang

Wan

et al. 2015

Arch Toxicol

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“…In particular, DON decreased SOD activity in embryo fibroblast DF-1 cells [161] and AFB1 feed contamination was associated with decreased SOD in the chicken liver [162][163] and erythrocytes [164]. However, the activities of SOD, GST and non-protein thiol levels in the chicken liver were not altered by the FB1-containing (100 mg/kg) diet fed for 21 days [165].…”

Section: Toxicological Stressesmentioning

confidence: 93%

Antioxidant Systems in Poultry Biology: Superoxide Dismutase

Surai¹

2016

J Anim Res Nutr

160

135

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Commercial poultry production is associated with various stresses responsible for decreasing productive and reproductive performance of growing chicks, breeders and commercial layers. A growing body of evidence shows that most of stresses in poultry production at the cellular level are associated with oxidative stress. Recently, a concept of the cellular antioxidant defense has been revised with special attention paid to cellular redox status maintenance and cell signaling. In fact, antioxidant systems of the living cell are based on three major levels of defense and superoxide dismutase (SOD) is shown to belong to the first level of the antioxidant defense network. Cellular antioxidant defenses are shown to include several options and vitagene activation in stress conditions is considered as a fundamental adaptive mechanism. The vitagene family includes various genes regulating synthesis of protective molecules including thioredoxins, sirtuins, heat shock proteins and SOD. However, by the time of writing no comprehensive review on the roles and effects of SOD in poultry biology has appeared. Therefore, the aim of this review is a critical analysis of the role of SOD in poultry biology with specific emphasis to its functions as an essential part of the vitagene network. From the analysis of the recent data related to SOD in poultry physiology and adaptation to stresses it is possible to conclude that: a) SOD as important vitagene is the main driving force in cell/body adaptation to various stress conditions. Indeed, in stress conditions additional synthesis of SOD is an adaptive mechanism to decrease ROS formation; b) If the stress is too high SOD activity is decreased and apoptosis is activated; c) there are tissue-specific differences in SOD expression which also depends on the strength of such stress-factors as heat, heavy metals, mycotoxins and other stressors; d) SOD is shown to provide an effective protection against lipid peroxidation in chicken embryonic tissues and semen; e) SOD is shown to be protective in heat and cold stress, toxicity stress as well as in other oxidative-stress related conditions in poultry production; f) there are complex interactions inside the antioxidant network of the cell/body to ensure an effective maintenance of homeostasis in stress conditions. Indeed, in many cases, nutritional antioxidants (vitamin E, selenium, carotenoids, phytochemicals, etc.) in the feed can increase SOD expression; g) nutritional means of SOD upregulation in stress conditions of poultry production and physiological and commercial consequences await further investigation; h) vitagene upregulation in stress conditions is emerging as an effective means for stress management.

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“…It has been shown that subacute treatment with FB 1 (100 mg/kg FB 1 in feed fed for 21 days) had significant negative effect on oxidative stress parameters in the liver of broiler chicks. It increased hepatic thiobarbituric acid reactive substance (TBARS) levels and catalase activity, however the superoxide dismutase and GST level were not altered (Poersch et al, 2014). Wang and Groopman (1999) reported that fumonisins are the only carcinogenic mycotoxins not having a direct DNA damage inducing effect, so genotoxicity is an indirect consequence of the oxidative damage caused by the toxin.…”

Section: Antioxidants and Genotoxicitymentioning

confidence: 99%

Individual and combined effects of feed artificially contaminated with with fumonisin B1 and T-2 toxin in weaned rabbits

Hafner

Szabó

D’Costa

et al. 2016

WMJ

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Co-contamination of feed and feed raw materials with two or more mycotoxins is frequently reported, however, only a few studies have investigated the combined effects of low doses of multiple mycotoxins. In the present study the individual and combined effects of 10 mg/kg fumonisin B 1 and 2 mg/kg T-2 toxin (n=12/group) were investigated in weaned rabbits. Mycotoxin contaminated feed was produced by adding fungal cultures of Fusarium verticillioides and Fusarium sporotrichioides, and fed to 40 days old rabbits during 28 days. Feed intake and body weight were measured weekly, serum biochemistry and antioxidant parameters on day 0, 14 and 28, while histopathological examination and comet assay were performed at the end of the experiment. T-2 exposure both alone and in combination resulted in 15-18% less final body weight compared to the control and FB 1 treatment. There was a significant increase in the concentration of plasma total protein, albumin, fructosamine and creatinine in the group treated with FB 1 compared to the control. The liver and the kidney of most animals treated with T-2 toxin, FB 1 and their combination showed pathological changes, occurring more frequent in animals exposed to both toxins. T-2 resulted in depletion of lymphocytes in the spleen. FB 1 and T-2 exerted synergistic effect on the antioxidant/oxidative parameters after 2 weeks of exposure, manifesting in less glutathione and glutathione peroxidase, while more malondialdehyde was produced. Both toxins caused DNA damage in the lymphocytes, which was more pronounced in the group fed T-2 toxin and T-2 combined with FB 1 , without additive or synergistic effects.

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Involvement of oxidative stress in subacute toxicity induced by fumonisin B1 in broiler chicks

Cited by 40 publications

References 30 publications

Fumonisins: oxidative stress-mediated toxicity and metabolism in vivo and in vitro

Fumonisins: oxidative stress-mediated toxicity and metabolism in vivo and in vitro

Antioxidant Systems in Poultry Biology: Superoxide Dismutase

Individual and combined effects of feed artificially contaminated with with fumonisin B1 and T-2 toxin in weaned rabbits

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