Involvement of opioid and dopaminergic systems in isolation-induced pinning and social grooming of young rats

Niesink, Raymond; Ree, Jan M. van

doi:10.1016/0028-3908(89)90038-5

Cited by 200 publications

(183 citation statements)

References 25 publications

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“…On the test day, the animals were socially isolated for 3.5 h before testing. This isolation period has been shown to induce a half-maximal increase in the amount of social play behavior (Niesink and Van Ree, 1989). At the appropriate time before testing, pairs of rats were assigned to one of the following treatments: (a) both rats injected with vehicle; (b) both rats injected with a drug (WIN55,212-2, URB597 or morphine); (c) one rat injected with a drug (WIN55,212-2, URB597 or morphine) and the other with the corresponding vehicle.…”

Section: Social Play Behaviormentioning

confidence: 99%

“…Social play is rewarding for adolescent rats (Calcagnetti and Schechter, 1992;Humphreys and Einon, 1981;Normansell and Panksepp, 1990;van den Berg et al, 1999b) and it is modulated by neural systems involved in reward and motivation, such as the opioid and dopaminergic systems (Vanderschuren et al, 1997;Siviy, 1998). Thus, treatment with morphine enhances (Niesink and Van Ree, 1989;Panksepp et al, 1985;Vanderschuren et al, 1995a) and treatment with opioid antagonists decreases social play behavior (Beatty and Costello, 1982;Panksepp et al, 1985;Siegel and Jensen, 1986;Siegel et al, 1985;Vanderschuren et al, 1995c). The role of dopaminergic neurotransmission in the modulation of social play is less clear, as both increases and decreases in social play behavior have been reported after treatment with dopamine receptor agonists (Niesink and Van Ree, 1989;Siviy et al, 1996;Vanderschuren et al, 1997Vanderschuren et al, , -2008Siviy, 1998).…”

Section: Introductionmentioning

confidence: 99%

“…Thus, treatment with morphine enhances (Niesink and Van Ree, 1989;Panksepp et al, 1985;Vanderschuren et al, 1995a) and treatment with opioid antagonists decreases social play behavior (Beatty and Costello, 1982;Panksepp et al, 1985;Siegel and Jensen, 1986;Siegel et al, 1985;Vanderschuren et al, 1995c). The role of dopaminergic neurotransmission in the modulation of social play is less clear, as both increases and decreases in social play behavior have been reported after treatment with dopamine receptor agonists (Niesink and Van Ree, 1989;Siviy et al, 1996;Vanderschuren et al, 1997Vanderschuren et al, , -2008Siviy, 1998).…”

Section: Introductionmentioning

confidence: 99%

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Cannabinoid and opioid modulation of social play behavior in adolescent rats: Differential behavioral mechanisms

Trezza¹,

Vanderschuren²

2008

European Neuropsychopharmacology

118

119

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We have recently shown that the pharmacological mechanisms through which cannabinoid and opioid drugs influence social play behavior in adolescent rats can be partially dissociated. Here, we characterize the effects of the direct cannabinoid agonist WIN55,212-2, the indirect cannabinoid agonist URB597 and the opioid agonist morphine on social play at the behavioral level. By treating either one or both partners of the test dyad, we show that these drugs differentially affect play solicitation and play responsiveness. By testing these drugs in animals which were either familiar or unfamiliar to the test cage, we show that environmental factors differentially modulate the effects of cannabinoid and opioid drugs on social play. These results support and extend our previous findings suggesting that, although cannabinoid and opioid systems interact in the modulation of social play behavior in adolescent rats, they do so through partially dissociable behavioral and pharmacological mechanisms.

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Section: Social Play Behaviormentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cannabinoid and opioid modulation of social play behavior in adolescent rats: Differential behavioral mechanisms

Trezza¹,

Vanderschuren²

2008

European Neuropsychopharmacology

118

119

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“…On the day of the experiment, the animals were socially isolated in cages measuring 43 Â 28 Â 15 cm (l Â w Â h) for 3.5 h prior to the experiment. This isolation period has been shown to produce a half maximal increase in the amount of social play (Niesink and Van Ree, 1989). The test consisted in placing two animals from the same group but different litters (VPA vs VPA, Con vs Con, VPA-E vs VPA-E, Con-E vs Con-E) into the test cage for 15 min.…”

Section: Behavioral Testsmentioning

confidence: 99%

Environmental Enrichment Reverses Behavioral Alterations in Rats Prenatally Exposed to Valproic Acid: Issues for a Therapeutic Approach in Autism

Schneider

Turczak

Przewłocki

2005

Neuropsychopharmacol

249

155

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Environmental enrichment has been repeatedly shown to affect multiple aspects of brain function, and is known to improve cognitive, behavioral, and histopathological outcome after brain injuries. The purpose of the present experiments was to determine the effect of an enriched environment on behavioral aberrations observed in male rats exposed to valproic acid on day 12.5 of gestation (VPA rats), and proposed on the basis of etiological, anatomical, and behavioral data as an animal model of autism. Environmental enrichment reversed almost all behavioral alterations observed in the model. VPA rats after environmental enrichment (VPA-E) compared to VPA rats reared in standard conditions have higher sensitivity to pain and lower sensitivity to nonpainful stimuli; stronger acoustic prepulse inhibition; lower locomotor, repetitive/stereotypic-like activity, and enhanced exploratory activity; decreased anxiety; increased number of social behaviors; and shorter latency to social explorations. In comparison with control animals (Con), VPA-E rats exhibited increased number of pinnings in adolescence and social explorations in adulthood, and were less anxious in the elevated plus maze. Similar differences in social behavior and anxiety were observed between control rats exposed to environmental enrichment (Con-E) and control group reared in standard conditions. These results suggest that postnatal environmental manipulations can counteract the behavioral alterations in VPA rats. We propose environmental enrichment as an important tool for the treatment of autism spectrum disorders.

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“…For example, treatment with dopamine receptor agonists and antagonists alters the expression of social play behavior (Niesink and Van Ree, 1989;Siviy et al, 1996;Vanderschuren et al, 2008;Trezza and Vanderschuren, 2009). In addition, the stimulation of social play by endocannabinoids, ethanol, and nicotine depends upon dopamine receptor stimulation Vanderschuren, 2008, 2009;Trezza et al, 2009b).…”

Section: Introductionmentioning

confidence: 99%

Contrasting Roles of Dopamine and Noradrenaline in the Motivational Properties of Social Play Behavior in Rats

Achterberg

Kerkhof

Servadio

et al. 2015

Neuropsychopharmacol

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Social play behavior, abundant in the young of most mammalian species, is thought to be important for social and cognitive development. Social play is highly rewarding, and as such, the expression of social play depends on its pleasurable and motivational properties. Since the motivational properties of social play have only sporadically been investigated, we developed a setup in which rats responded for social play under a progressive ratio schedule of reinforcement. Dopaminergic neurotransmission plays a key role in incentive motivational processes, and both dopamine and noradrenaline have been implicated in the modulation of social play behavior. Therefore, we investigated the role of dopamine and noradrenaline in the motivation for social play. Treatment with the psychostimulant drugs methylphenidate and cocaine increased responding for social play, but suppressed its expression during reinforced play periods. The dopamine reuptake inhibitor GBR-12909 increased responding for social play, but did not affect its expression, whereas the noradrenaline reuptake inhibitor atomoxetine decreased responding for social play as well as its expression. The effects of methylphenidate and cocaine on responding for social play, but not their play-suppressant effects, were blocked by pretreatment with the dopamine receptor antagonist α-flupenthixol. In contrast, pretreatment with the α2-adrenoceptor antagonist RX821002 prevented the play-suppressant effect of methylphenidate, but left its effect on responding for social play unaltered. In sum, the present study introduces a novel method to study the incentive motivational properties of social play behavior in rats. Using this paradigm, we demonstrate dissociable roles for dopamine and noradrenaline in social play behavior: dopamine stimulates the motivation for social play, whereas noradrenaline negatively modulates the motivation for social play behavior and its expression.

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Involvement of opioid and dopaminergic systems in isolation-induced pinning and social grooming of young rats

Cited by 200 publications

References 25 publications

Cannabinoid and opioid modulation of social play behavior in adolescent rats: Differential behavioral mechanisms

Cannabinoid and opioid modulation of social play behavior in adolescent rats: Differential behavioral mechanisms

Environmental Enrichment Reverses Behavioral Alterations in Rats Prenatally Exposed to Valproic Acid: Issues for a Therapeutic Approach in Autism

Contrasting Roles of Dopamine and Noradrenaline in the Motivational Properties of Social Play Behavior in Rats

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