Involvement of nuclear factor κB and descending pain pathways in the anti-hyperalgesic effect of β-citronellol, a food ingredient, complexed in β-cyclodextrin in a model of complex regional pain syndrome - Type 1

Santos, Priscila L.; Rabelo, Thallita Kelly; Matos, João Pedro S. C. F.; Anjos, Klécia Santos dos; Melo, Marlange Almeida Oliveira; Carvalho, Yasmim Maria Barbosa Gomes de; Lima, Bruno S.; Menezes, Paula P.; Araújo, Adriano A. S.; Picot, Laurent; Almeida, Jackson Roberto Guedes da Silva; Brito, Renan Guedes de; Quintans‐Júnior, Lucindo J.

doi:10.1016/j.fct.2021.112260

Cited by 6 publications

(3 citation statements)

References 35 publications

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“…The concentrations of TNF in the paw skin and muscle in mice from the Saline/CPIP group at 2 days post-CPIP were not significantly changed compared to the Saline/Sham group. In a prior study using the CPIP model, TNF concentrations were found to be increased 1, 2, and 7 days post-I/R in the skin and muscle of the paw ( Hsiao et al, 2016 ; Santos et al, 2021 ) although this study was conducted in male rather than female Swiss mice. On the other hand, Laferrière et al (2008) observed in male rats that TNF levels were increased at 2 h post-injury and returned to baseline levels on the 2nd-day post-I/R, consistent with our findings.…”

Section: Discussionmentioning

confidence: 92%

“…Following I/R injury, there is a significant increase in the formation of reactive oxygen species, oxidative stress, and activation of resident immune cells (mainly macrophages). More specifically, there is increased activity in pro-inflammatory cytokine signaling pathways involving TNF, IL-1β, and IL-6 in the paw skin and muscle ( Laferrière et al, 2008 ; Hsiao et al, 2016 ; Klafke et al, 2016 ; Hewedy, 2018 ; Santos et al, 2021 ). These changes are typical of early CRPS-I in humans, causing induction and regulation of the inflammatory response and contributing to neurogenic inflammation ( Laferrière et al, 2008 ; Marinus et al, 2011 ; Klafke et al, 2016 ; Hewedy, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

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Immunoregulatory Effect of Preventive Supplementation of Omega-3 Fatty Acid in a Complex Regional Pain Syndrome Type I Model in Mice

Fernandes

Galassi

Horewicz

et al. 2022

Front. Integr. Neurosci.

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ObjectiveComplex regional pain syndrome (CRPS) is usually triggered by trauma or a surgical procedure, and it typically becomes an established one after an intense inflammatory process with chronic pain and edema as the main symptoms. Available treatments for CRPS have low efficacy. This study aimed to evaluate the clinical and immunoregulatory effects of omega-3 polyunsaturated fatty acid (PUFA) supplementation on paw edema and anti- and pro-inflammatory cytokines and macrophage phenotypes in the chronic post-ischemia pain (CPIP) preclinical model of CRPS-Type I.MethodsFemale Swiss mice were supplemented with omega-3, corn oil, or saline and then submitted to the CPIP model of ischemia/reperfusion (I/R) injury. Supplementation was carried out for 30 days prior to and up to 2 or 15 days after the induction of CPIP, according to experimental protocols. The supplementation protocol included 1,500 mg/kg of omega-3 or corn oil through an intragastric route (gavage). Paw edema, interleukin- (IL-) 4, IL-10, transforming growth factor-β1 (TGF-β1), monocyte chemotactic protein-1 (MCP-1), and tumor necrosis factor (TNF) were then measured in the paw skin and muscle by enzyme-linked immunosorbent assay (ELISA), and macrophage phenotypes (M1 and M2) assessed in the paw muscle by Western blotting.ResultsThe CPIP model induced an increase in paw thickness up to 72 h post-I/R. Mice supplemented with omega-3 compared to the saline group displayed reduced edema but neither altered skin IL-4 or skin and muscle TGF-β1, TNF, and MCP-1 concentrations, nor did they exhibit significantly altered muscle macrophage phenotype on the 2nd-day post-CPIP. However, omega-3 supplementation reversed the I/R-related reduction in IL-4 in the paw muscle compared to groups supplemented with saline and corn oil. Furthermore, omega-3 promoted the reduction of IL-10 levels in the paw skin, compared to animals with lesions supplemented with saline, until the 2nd-day post-CPIP. On the 15th day post-CPIP, IL-10 was significantly increased in the muscle of animals supplemented with omega-3 compared to the saline group.ConclusionThe results suggest that omega-3 PUFA supplementation has anti-inflammatory effects in the CPIP model of CRPS-Type I, significantly reducing paw edema and regulating concentrations of anti-inflammatory cytokines, including IL-4 and IL-10.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Immunoregulatory Effect of Preventive Supplementation of Omega-3 Fatty Acid in a Complex Regional Pain Syndrome Type I Model in Mice

Fernandes

Galassi

Horewicz

et al. 2022

Front. Integr. Neurosci.

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“…Numerous research works have been carried out in this important field in the last decade. High analgesic activity was demonstrated for (−)-linalool [37] and its acetate [38], citronellal [39], p-cymene [40,41], camphor [42], α-terpineol [43][44][45][46], menthol [47], myrcene [48], limonene [49,50], pulegone [51], citronellol [52], cuminic alcohol [53], and 1,8-cineole [54]. The anti-inflammatory activity of monoterpenes was reviewed by Araruna et al (2020) [55].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Myrtenal and Its Derivatives—A Review

Dragomanova,

Andonova,

Volcho

et al. 2023

Life

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The investigation of monoterpenes as natural products has gained significant attention in the search for new pharmacological agents due to their ability to exhibit a wide range in biological activities, including antifungal, antibacterial, antioxidant, anticancer, antispasmodic, hypotensive, and vasodilating properties. In vitro and in vivo studies reveal their antidepressant, anxiolytic, and memory-enhancing effects in experimental dementia and Parkinson’s disease. Chemical modification of natural substances by conjugation with various synthetic components is a modern method of obtaining new biologically active compounds. The discovery of new potential drugs among monoterpene derivatives is a progressive avenue within experimental pharmacology, offering a promising approach for the therapy of diverse pathological conditions. Biologically active substances such as monoterpenes, for example, borneol, camphor, geraniol, pinene, and thymol, are used to synthesize compounds with analgesic, anti-inflammatory, anticonvulsive, antidepressant, anti-Alzheimer’s, antiparkinsonian, antiviral and antibacterial (antituberculosis) properties. Myrtenal is a perspective monoterpenoid with therapeutic potential in various fields of medicine. Its chemical modifications often lead to new or more pronounced biological effects. As an example, the conjugation of myrtenal with the established pharmacophore adamantane enables the augmentation of several of its pivotal properties. Myrtenal–adamantane derivatives exhibited a variety of beneficial characteristics, such as antimicrobial, antifungal, antiviral, anticancer, anxiolytic, and neuroprotective properties, which are worth examining in more detail and at length.

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Nigella sativa L. and its bioactive and nutraceutical components in the management of diabetic peripheral neuropathy

Khodaie,

Razavi,

Nikkhah

et al. 2024

Inflammopharmacol

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Involvement of nuclear factor κB and descending pain pathways in the anti-hyperalgesic effect of β-citronellol, a food ingredient, complexed in β-cyclodextrin in a model of complex regional pain syndrome - Type 1

Cited by 6 publications

References 35 publications

Immunoregulatory Effect of Preventive Supplementation of Omega-3 Fatty Acid in a Complex Regional Pain Syndrome Type I Model in Mice

Immunoregulatory Effect of Preventive Supplementation of Omega-3 Fatty Acid in a Complex Regional Pain Syndrome Type I Model in Mice

Therapeutic Potential of Myrtenal and Its Derivatives—A Review

Nigella sativa L. and its bioactive and nutraceutical components in the management of diabetic peripheral neuropathy

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