Involvement of Nitric Oxide in the Elimination of a Transient Retinotectal Projection in Development

Wu, Hope H.; Williams, Cheri V.; McLoon, Steven C.

doi:10.1126/science.7521541

Cited by 220 publications

(154 citation statements)

References 48 publications

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“…Because blockade of NOS at early ages does not interfere with the formation of eye-specific layers, it is unlikely that NO produced in the neuropil is involved in early retinogeniculate pattern formation. A developmental role for NO has also been found in the chick retinotectal pathway, where NOS expression is highest during the removal of a transient ipsilateral projection and blockade of NOS results in the retention of this projection (Wu et al, 1994). NO is thus required for the refinement of eye-specific projections from the retina to the optic tectum in the chick.…”

Section: Discussionmentioning

confidence: 94%

“…Nitric oxide (NO) has been proposed as a diffusible retrograde messenger in the maintenance of hippocampal long-term potentiation (LTP) (Bohme et al, 1991;O'Dell et al, 1991;Schuman and Madison, 1991;Haley et al, 1992;cf. Gribkoff and Lum-Ragan, 1992) and, by analogy, in activity-dependent refinement of connections in the visual pathway during development (Montague et al, 1991;Wu et al, 1994;.…”

Section: Abstract: Diffusible Messenger; Visual System; Lateral Genimentioning

confidence: 99%

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A Role for Nitric Oxide in the Development of the Ferret Retinogeniculate Projection

et al. 1996

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The ferret retinogeniculate projection segregates into eyespecific layers during the first postnatal week and into ON/OFF sublaminae, which receive inputs from either on-center or offcenter retinal ganglion cells, during the third and fourth postnatal weeks. The restriction of retinogeniculate axon arbors into eye-specific layers appears to depend on action potential activity (Shatz and Stryker, 1988) but does not require activation of NMDA receptors (Smetters et al., 1994). The formation of ON/OFF sublaminae is also activity-dependent and is disrupted by in vivo blockade of NMDA receptors (Hahm et al., 1991). To investigate a possible mechanism whereby blockade of postsynaptic NMDA receptors in the lateral geniculate nucleus (LGN) results in changes in the size and position of presynaptic axon arbors, we tested the role of the diffusible messenger nitric oxide (NO) in the development of the retinogeniculate pathway. We found previously that NO synthase (NOS) is transiently expressed in LGN cells during the refinement of retinogeniculate projections . In this study, treatment with N G -nitro-L-arginine (L-NoArg), an arginine analog that inhibits NOS, during the third and fourth postnatal weeks resulted in an overall pattern of sublamination that was significantly reduced compared with normal and control animals. Single retinogeniculate axon arbors were located in the middle of eye-specific layers rather than toward the inner or outer half as in normal or control animals. The effect of NOS inhibition was not a consequence of the hypertensive effect of L-NoArg. In contrast to the effect of L-NoArg on the formation of ON/OFF sublaminae, treatment with L-NoArg during the first postnatal week did not disrupt the formation of eye-specific layers. Biochemical assays indicated significant inhibition of NOS during both treatment periods. These data suggest that NO acts together with NMDA receptors in activity-dependent refinement of connections during a specific phase of retinogeniculate development. Key words: diffusible messenger; visual system; lateral geniculate nucleus (LGN); pattern formation; eye-specific layers; ON/ OFF sublaminae; neuronal activityThe precise pattern of connections underlying adult visual processing in mammals arises from the refinement of less specific connectivity present early in development. The mechanisms by which diffuse connections are refined rely at least in part on neuronal activity. In the ferret, retinogeniculate connections are refined in two distinct phases. During the first postnatal week, retinal axons within the lateral geniculate nucleus (LGN) segregate into eye-specific layers (Linden et al., 1981). During the third and fourth postnatal weeks, afferents to the A and A1 layers, which receive input from the contralateral and ipsilateral eye, respectively, further segregate into sublaminae. The inner sublamina receives inputs from on-center retinal ganglion cells, whereas the outer sublamina receives inputs from off-center retinal ganglion cells (Stryker and Zahs, 1983;Hahm and S...

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Section: Discussionmentioning

confidence: 94%

Section: Abstract: Diffusible Messenger; Visual System; Lateral Genimentioning

confidence: 99%

A Role for Nitric Oxide in the Development of the Ferret Retinogeniculate Projection

et al. 1996

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“…Mechanisms of this kind may be involved in the regulation of motility of radial glial cells during development, as described in the optic tectum of Xenopus tadpoles [69] In this model, in vivo observations demonstrated that extension and retraction of filopodial processes from radial glia was modulated by visual stimulation through NO signaling downstream NMDA receptor activation [69]. These interactions may be at the basis of the role ascribed to NO in the refinement of retino-tectal and retino-geniculate projections [70-72] and in the regulation of the wiring of the insect nervous system [73]. NO-mediated interactions are not restricted to mechanisms of axon migration and wiring, but they are also involved in developmental migration of neuroblasts and neuronal precursors [74-76].…”

Section: Nitric Oxide-mediated Metabolic and Functional Interactions mentioning

confidence: 99%

Neuronal-glial Interactions Define the Role of Nitric Oxide in Neural Functional Processes

Contestabile¹,

Monti²,

Polazzi³

2012

Current Neuropharmacology

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Nitric oxide (NO) is a versatile cellular messenger performing a variety of physiologic and pathologic actions in most tissues. It is particularly important in the nervous system, where it is involved in multiple functions, as well as in neuropathology, when produced in excess. Several of these functions are based on interactions between NO produced by neurons and NO produced by glial cells, mainly astrocytes and microglia. The present paper briefly reviews some of these interactions, in particular those involved in metabolic regulation, control of cerebral blood flow, axonogenesis, synaptic function and neurogenesis. Aim of the paper is mainly to underline the physiologic aspects of these interactions rather than the pathologic ones.

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“…NO appears to be involved in the removal of transient retinotectal projections, since the blockade of NOS activity results in the maintenance of such connections [47]. Cramer et al reported that NADPH-d activity reaches a peak at about the fourth postnatal week, and then declines by the sixth postnatal week [48], and suggested that this transient expression of NADPH-d may be involved in the development of mature connections within the ferret lateral geniculate nucleus.…”

Section: Posterior Pituitarymentioning

confidence: 99%

Postnatal Development of NADPH-Diaphorase Activity in the Rat. The Role of Nitric Oxide in the Ontogeny of Arginine Vasopression and Oxytocin.

et al. 2000

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Abstract.To clarify the role of nitric oxide (NO) in the ontogeny of arginine vasopressin (AVP) and oxytocin (OXT) neurons in the hypothalamo-neurohypophysial system (HNS), we observed the coexpression pattern of NADPHdiaphorase (NADPH-d) activity and AVP-or OXT-immunoreactivity (IR) in the rat hypothalamus and posterior pituitary during the postnatal period. The enzymatic activity of NADPH-d was observed in the supraoptic nucleus (SON), paraventricular nucleus (PVN), median eminence (ME) and posterior pituitary throughout the postnatal development. AVP-containing neurons were clearly observed from postnatal day 1 in both the SON and PVN, while OXT-containing neurons were recognized from postnatal day 14. The coexistence of NADPH-d and AVP or OXT was detected in the SON from postnatal day 14. At postnatal day 21, the coexpression pattern was approximately the same as that of the SON and PVN in adult rats. Our findings indicated that the expression of NADPH-d and OXT was observed from almost the same postnatal period in both the SON and PVN. In addition, the pattern of increased numbers of NADPH-d positive fibers was similar to that of OXT-immunoreactive fibers in both the inner layer of the ME and the posterior pituitary.A good correlation was thus obtained between OXT expression and NADPH-d activity in the HNS during postnatal development.The present study suggests that NO is more closely involved in the expression and regulation of secretion of OXT than AVP.

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Involvement of Nitric Oxide in the Elimination of a Transient Retinotectal Projection in Development

Cited by 220 publications

References 48 publications

A Role for Nitric Oxide in the Development of the Ferret Retinogeniculate Projection

A Role for Nitric Oxide in the Development of the Ferret Retinogeniculate Projection

Neuronal-glial Interactions Define the Role of Nitric Oxide in Neural Functional Processes

Postnatal Development of NADPH-Diaphorase Activity in the Rat. The Role of Nitric Oxide in the Ontogeny of Arginine Vasopression and Oxytocin.

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