Involvement of Nicotinic Receptors in Working Memory Function

Galvin, Veronica C.; Arnsten, Amy F.T.; Wang, Min

doi:10.1007/7854_2020_142

Cited by 14 publications

(12 citation statements)

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“…The heteromeric α4β2 and the homomeric α7 nAChR subtypes are the most relevant ones, among others [31,32]. nAChR are involved in many different behaviours, including memory [33] and addiction [34], and play a pivotal in the anxiolytic activity of nicotine [35]. In relation to gene expression, it has been demonstrated that nicotine administration produces an increment in the mRNA levels of nAChR subunit α7 in mice [36,37], but it has also been observed that nicotine upregulates nAChRs without noticeable changes in mRNA levels [38,39].…”

Section: Introductionmentioning

confidence: 99%

Nicotinic Antagonist UFR2709 Inhibits Nicotine Reward and Decreases Anxiety in Zebrafish

et al. 2020

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Zebrafish is becoming a popular animal model in neuropharmacology and drug discovery, mainly due to its ease of handling and low costs involved in maintenance and experimental work. This animal displays a series of complex behaviours that makes it useful for assessing the effects of psychoactive drugs. Here, adult zebrafish were used for assessment of the anxiolytic and anti-addictive properties of UFR2709, a nicotinic receptor (nAChR) antagonist, using two behavioural paradigms to test for addiction, the novel tank diving test to assess anxiety and the conditioned place preference (CPP). Furthermore, the expression of nAChR subunits α4 and α7 was measured in the zebrafish brain. The results show that UFR2709 exhibits an anxiolytic effect on zebrafish and blocks the effect evoked by nicotine on CPP. Moreover, UFR2709 significantly decreased the expression of α4 nicotinic receptor subunit. This indicates that UFR2709 might be a useful drug for the treatment of nicotine addiction.

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Section: Introductionmentioning

confidence: 99%

Nicotinic Antagonist UFR2709 Inhibits Nicotine Reward and Decreases Anxiety in Zebrafish

et al. 2020

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“…These receptors can be activated by both endogenous ligand, ACh, and exogenous ligands, such as nicotine. ,, They are also involved in the regulation of processes like cell excitability, transmitter release, and neuronal integration by acetylcholine-mediated innervation, which contributes to their critical role in modulating a wide range of physiological processes, including pain, fatigue, cognition function, sleep, and arousal . nAChRs are critical in early pre- and perinatal circuit formation and age-related cell degeneration, making them an important target in the pathogenesis of various neurological disorders and neurodegenerative diseases such as AD, PD, myasthenia gravis, and atherosclerosis. ,− …”

Section: Pet Tracers Targeting Nicotinic Acetylcholine Receptors (Nac...mentioning

confidence: 99%

Imaging Cholinergic Receptors in the Brain by Positron Emission Tomography

Zhang

Lin

et al. 2023

J. Med. Chem.

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“…Subtypes from both cholinergic receptor families function in cortical WM circuitry, including in the PFC. There has recently been considerable interest in how ACh, acting through these receptors, influences neurophysiology of primate PFC during the performance of WM tasks (Baxter and Crimins, 2018;Galvin et al, 2018Galvin et al, , 2020aVijayraghavan et al, 2018). Here, we will review studies of cortical muscarinic neuromodulation of WM performance and recapitulate recent work from our laboratory and others exploring muscarinic neuropharmacology of persistent activity and WM representations in primate PFC.…”

Section: Introductionmentioning

confidence: 98%

Neuromodulation of Persistent Activity and Working Memory Circuitry in Primate Prefrontal Cortex by Muscarinic Receptors

Vijayraghavan

Everling

2021

Front. Neural Circuits

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Neuromodulation by acetylcholine plays a vital role in shaping the physiology and functions of cerebral cortex. Cholinergic neuromodulation influences brain-state transitions, controls the gating of cortical sensory stimulus responses, and has been shown to influence the generation and maintenance of persistent activity in prefrontal cortex. Here we review our current understanding of the role of muscarinic cholinergic receptors in primate prefrontal cortex during its engagement in the performance of working memory tasks. We summarize the localization of muscarinic receptors in prefrontal cortex, review the effects of muscarinic neuromodulation on arousal, working memory and cognitive control tasks, and describe the effects of muscarinic M1 receptor stimulation and blockade on the generation and maintenance of persistent activity of prefrontal neurons encoding working memory representations. Recent studies describing the pharmacological effects of M1 receptors on prefrontal persistent activity demonstrate the heterogeneity of muscarinic actions and delineate unexpected modulatory effects discovered in primate prefrontal cortex when compared with studies in rodents. Understanding the underlying mechanisms by which muscarinic receptors regulate prefrontal cognitive control circuitry will inform the search of muscarinic-based therapeutic targets in the treatment of neuropsychiatric disorders.

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Involvement of Nicotinic Receptors in Working Memory Function

Cited by 14 publications

References 50 publications

Nicotinic Antagonist UFR2709 Inhibits Nicotine Reward and Decreases Anxiety in Zebrafish

Nicotinic Antagonist UFR2709 Inhibits Nicotine Reward and Decreases Anxiety in Zebrafish

Imaging Cholinergic Receptors in the Brain by Positron Emission Tomography

Neuromodulation of Persistent Activity and Working Memory Circuitry in Primate Prefrontal Cortex by Muscarinic Receptors

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