Involvement of Na+/Ca2+ exchanger in catecholamine-induced increase in intracellular calcium in cardiomyocytes

Saini, Harjot K.; Tripathi, O.; Zhang, Shetuan; Elimban, Vijayan; Dhalla, Naranjan S.

doi:10.1152/ajpheart.00613.2005

Cited by 31 publications

(35 citation statements)

References 37 publications

(76 reference statements)

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“…Magnesium deficiency, in particular when combined with stress and catecholamine secretion, might lead to enhanced entry of calcium into VSMC, which in turn can result in increased arteriolar tone and coronary spasm. Hypertension and its complications may also be the final consequences of increased calcium influx and contraction of VSMC [1,51] . Moreover, it was observed that magnesium acts on most types of calcium channels in VSMC exerting substantial arterial blood pressure-lowering properties, resulting in a reduction of peripheral and cerebral vascular resistance [37,52] .…”

Section: Discussionmentioning

confidence: 99%

Lower Serum Magnesium Is Associated with Cardiovascular Risk Factors and Mortality in Haemodialysis Patients

et al. 2014

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Background: Hypomagnesaemia is a cardiovascular (CV) risk factor in the general population. The aim of this study was to evaluate the relationship between pre-dialysis magnesium (Mg) and CV risk markers, [including pulse pressure (PP), left ventricular mass index (LVMI) and vascular calcifications (VC)], and mortality in haemodialysis (HD) patients. Methods: We performed a 48-month prospective study in 206 patients under pre-dilution haemodiafiltration with a dialysate Mg concentration of 1 mmol/l. Results: Lower Mg concentrations were predictors of an increased PP (≥65 mm Hg) (p = 0.002) and LVMI (≥140 g/m2) (p = 0.03) and of a higher VC score (≥3) (p = 0.01). Patients with Mg <1.15 mmol/l had a lower survival at the end of the study (p = 0.01). Serum Mg <1.15 mmol/l was an independent predictor of all-cause (p = 0.01) and CV mortality (p = 0.02) when adjusted for multiple CV risk factors. Conclusions: Lower Mg levels seem to be associated with increased CV risk markers, like PP, LVMI and VC, and with higher mortality in HD patients.

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Section: Discussionmentioning

confidence: 99%

Lower Serum Magnesium Is Associated with Cardiovascular Risk Factors and Mortality in Haemodialysis Patients

et al. 2014

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“…Severe hyponatremia also leads to intracellular accumulation of calcium due to functional disturbance of membrane sodium/calcium ion pumps, because, in addition to L-type calcium ion channels, the sodium/ calcium ion exchanger may play an important role in catecholamine-induced increases in intracellular calcium in cardiomyocytes [18]. Thus, cardiac sodium/ calcium ion exchange is critical in the regulation of cardiac myocyte calcium, and its altered function contributes to systolic dysfunction in heart failure and arrhythmogenesis [19].…”

Section: Discussionmentioning

confidence: 99%

Ampulla (Takotsubo) Cardiomyopathy Caused by Secondary Adrenal Insufficiency in ACTH Isolated Deficiency

et al. 2007

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Abstract. We describe here a case of reversible ampulla (takotsubo) cardiomyopathy caused by secondary adrenal insufficiency in ACTH isolated deficiency. A 53-year-old woman was referred to our department for evaluation and treatment of unconsciousness. On admission, her plasma glucose level was 34 mg/dL, suggesting loss of consciousness due to hypoglycemia. Basal levels of ACTH, cortisol, and dehydroepiandrosterone sulfate in blood, and urinary free cortisol levels were all decreased. ACTH and cortisol levels were not adequately increased in response to CRH administration and the insulin tolerance test. Electrocardiography showed ST segment elevation and T wave inversion in leads V 1-6 . The coronary arteries were free of organic stenosis, and a left ventriculogram revealed severe hypokinesis, particularly in the anterior and posterior walls. Based on a diagnosis of adrenocortical insufficiency caused by ACTH isolated deficiency, hydrocortisone was administered. Two weeks after treatment, ultrasound studies of the heart showed recovery of left ventricular wall motion. Activation of the sympathetic nervous system, adrenocortical failure, and hypoglycemic attack were considered to be triggering factors for the takotsubo cardiomyopathy. Careful monitoring of cardiac function and appropriate treatments for both cardiomyopathy and adrenocortical failure are required to recover cardiac dysfunction.

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“…The results regarding the effects of Ca 2ϩ antagonists verapamil and diltiazem (38), as well as Na ϩ /Ca 2ϩ exchange inhibitors amiloride and KB- R7943 (38), on recovery of cardiac performance and mitochondrial function of the 30-min I/R hearts are shown in Table 3. Although the increased LVEDP in I/R hearts was significantly reduced by all these agents, both verapamil and amiloride further attenuated the recovery of depressed LVDP, whereas diltiazem and KB-R7943 had no effect on the recovery of depressed LVDP due to I/R.…”

Section: Duration Of Ischemia and Mitochondrial Functionmentioning

confidence: 99%

Role of oxidative stress in alterations of mitochondrial function in ischemic-reperfused hearts

Makazan¹,

Saini²,

Dhalla³

2007

American Journal of Physiology-Heart and Circulatory Physiology

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Makazan Z, Saini HK, Dhalla NS. Role of oxidative stress in alterations of mitochondrial function in ischemic-reperfused hearts. Am J Physiol Heart Circ Physiol 292: H1986 -H1994, 2007. First published December 15, 2006; doi:10.1152/ajpheart.01214.2006.-To study the mechanisms of mitochondrial dysfunction due to ischemiareperfusion (I/R) injury, rat hearts were subjected to 20 or 30 min of global ischemia followed by 30 min of reperfusion. After recording both left ventricular developed pressure (LVDP) and end-diastolic pressure (LVEDP) to monitor the status of cardiac performance, mitochondria from these hearts were isolated to determine respiratory and oxidative phosphorylation activities. Although hearts subjected to 20 min of ischemia failed to generate LVDP and showed a marked increase in LVEDP, no changes in mitochondrial respiration and phosphorylation were observed. Reperfusion of 20-min ischemic hearts depressed mitochondrial function significantly but recovered LVDP completely and lowered the elevated LVEDP. On the other hand, depressed LVDP and elevated LVEDP in 30-min ischemic hearts were associated with depressions in both mitochondrial respiration and oxidative phosphorylation. Reperfusion of 30-min ischemic hearts elevated LVEDP, attenuated LVDP, and decreased mitochondrial state 3 and uncoupled respiration, respiratory control index, ADP-to-O ratio, as well as oxidative phosphorylation rate. Alterations of cardiac performance and mitochondrial function in I/R hearts were attenuated or prevented by pretreatment with oxyradical scavenging mixture (superoxide dismutase and catalase) or antioxidants [N-acetyl-L-cysteine or N-(2-mercaptopropionyl)-glycine]. Furthermore, alterations in cardiac performance and mitochondrial function due to I/R were simulated by an oxyradical-generating system (xanthine plus xanthine oxidase) and an oxidant (H 2O2) either upon perfusing the heart or upon incubation with mitochondria. These results support the view that oxidative stress plays an important role in inducing changes in cardiac performance and mitochondrial function due to I/R. cardiac performance; oxidative phosphorylation; mitochondrial respiration; oxyradicals; antioxidants BY VIRTUE OF THEIR ABILITY to carry on the processes of oxidative phosphorylation and electron transport, mitochondria are the major source of energy production in the form of ATP, which is required for cardiac contraction and relaxation (19,26,46). Mitochondria are also known to accumulate a substantial amount of Ca 2ϩ and are considered to serve as a sink to maintain the intracellular concentration of free Ca 2ϩ within certain limits (18,19,26). However, an excessive amount of intracellular Ca 2ϩ results in the overloading of mitochondria with Ca 2ϩ

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Involvement of Na⁺/Ca²⁺ exchanger in catecholamine-induced increase in intracellular calcium in cardiomyocytes

Cited by 31 publications

References 37 publications

Lower Serum Magnesium Is Associated with Cardiovascular Risk Factors and Mortality in Haemodialysis Patients

Lower Serum Magnesium Is Associated with Cardiovascular Risk Factors and Mortality in Haemodialysis Patients

Ampulla (Takotsubo) Cardiomyopathy Caused by Secondary Adrenal Insufficiency in ACTH Isolated Deficiency

Role of oxidative stress in alterations of mitochondrial function in ischemic-reperfused hearts

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