Involvement of MTHFR rs1801133 in the Susceptibility of Acute Lymphoblastic Leukemia: A Preliminary Study

Abstract

Background: Acute lymphoblastic leukemia (ALL), a common blood cancer, is characterized by the interaction between genetic and environmental factors. Several variants of the Methylenetetrahydrofolate reductase (MTHFR), mainly the C677T (rs1801133), may affect susceptibility to ALL. Aim of the Study: The authors conducted this case-control study to evaluate the relationship between this variant of the MTHFR gene and the risk of ALL. Materials and Methods: Forty-one patients with ALL and 35 non-ALL controls recruited in this study were genotyped utilizing polymerase chain reaction-restriction fragment length polymorphism methodology. Results: The MTHFR 677CT genotype was significantly more frequently found in patients with ALL having a 2-fold increase in risk (P <0.01). Conclusion: Our results suggest that rs1801133 of MTHFR is a predictive risk marker to ALL in Tunisian ALL.

Polymorphisms in the CYP2A6 and ABCC4 genes are associated with a protective effect on chronic myeloid leukemia in the Brazilian Amazon population

“…Carcinogenesis is a multistep process that involves both genetic and environmental risk factors. The presence of genetic polymorphisms in pivotal genes may affect the structure, function, stability or folding of the encoded proteins, which may initiate a carcinogenic event (Frikha et al, 2020 ; Zhang & Zhu, 2020 ). The present study evaluated the possible association of SNPs in genes of key cellular pathways, such as the transport of substances across cell membranes, DNA repair, the folate and xenobiotic metabolisms, and pyrimidine synthesis, with a predisposition to the development of CML.…”