Involvement of monoaminergic system in the antidepressant-like effect of (octylseleno)-xylofuranoside in the mouse tail suspension test

Brod, Lucimar M. Pinto; Fronza, Mariana G.; Vargas, Jaqueline Pinto; Lüdtke, Diogo S.; Luchese, Cristiane; Savegnago, Lucielli

doi:10.1016/j.pnpbp.2015.10.008

Cited by 45 publications

(11 citation statements)

References 59 publications

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“…In the same manner as previously, FST and OFT were performed after 30 minutes of the compound administration. It is worth mentioning that, these methodologies were based in previous studies from Savegnago et al (2008) [ 42 ]; Martinez et al (2014) [ 43 ]; Pesarico et al (2014) [ 44 ] and Brod et al (2016) [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

“…Several additional studies also demonstrated antidepressant-like activity can be exerted by organoselenium compounds, i.e. (octylseleno)-xylofuranoside [ 24 ], α-(phenylselanyl) acetophenone [ 25 ], α-phenylselenocitronellal [ 26 ], 3-(4-fluorophenylselenyl)-2,5-diphenylselenophene [ 27 ] and m-trifluoromethyl-diphenyl diselenide [ 28 ]. In parallel, studies have reported that insufficient selenium intake may also affect some psychological roles and the supplementation with selenium was found to be associated with improvements in mood and depression status [ 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

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Computational and biological evidences on the serotonergic involvement of SeTACN antidepressant-like effect in mice

et al. 2017

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A series of phenylselanyl-1H-1,2,3-triazole-4-carbonitriles with different substituents were screened for their binding affinity with serotonin transporter (SERT) and dopamine transporter (DAT) by docking molecular. 5-(4methoxyphenyl)-1-(2-(phenylselanyl)phenyl)-1H-1,2,3-triazole-4-carbonitrile (SeTACN) exhibited the best conformation with SERT even higher than fluoxetine and serotonin, suggesting a competitive inhibition. SeTACN demonstrated additional affinity to other serotonergic receptors involved in antidepressant effects: 5HT1a, 5HT2a and 5HT3. In another set of experiments, SeTACN led to significant reductions in the immobility time of mice submitted to forced swimming test (FST) in the dose range of 0.1- 20mg/kg, suggesting an antidepressant-like effect. The possible mechanism of action was investigated using serotonergic and dopaminergic antagonists. The antidepressant-like effect of SeTACN (0.1mg/kg i.g.) was prevented by the pretreatment with WAY100635 (a selective 5HT1a antagonist), ketanserin (a 5HT2a/c antagonist) and ondansetron (a selective 5ht3 antagonist), PCPA (an inhibitor of serotonin synthesis) but not with SCH23390 (dopaminergic D1 antagonist) and sulpiride (D2 antagonist). Sub-effective dose of fluoxetine was able to potentiate the effects of a sub-effective dose of SeTACN in FST. None of the treatments affected locomotor activity in open field test (OFT). These results together, suggest that the SeTACN antidepressant-like effect is mediate, at least in parts, by serotonergic system.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Computational and biological evidences on the serotonergic involvement of SeTACN antidepressant-like effect in mice

et al. 2017

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“…The observed effects of MPI may be related to its chemical structure, which combines selenium and imidazopyridine. Organoselenium compounds can exert a variety of biological actions, including anti-inflammatory, neuroprotective, antioxidant, and antidepressant activities ( da Rocha et al, 2012 ; Pinto Brod et al, 2016 ; Casaril et al, 2017 ). Similarly, imidazopyridines also present several pharmacological properties, such as anti-inflammatory ( Qian et al, 2016 ), antiviral, antioxidant, and neuroprotective ( Dymińska, 2015 ) activities.…”

Section: Discussionmentioning

confidence: 99%

“…In this context, the selenium-containing compounds have received attention, since these molecules demonstrate an amplitude of biological properties ( da Rocha et al, 2012 ). Among the biological functions, they have been widely explored in the literature as anti-inflammatory, antioxidant, and antidepressant ( Tiegs et al, 1998 ; Bortolatto et al, 2013 ; Pinto Brod et al, 2016 ). Donato et al (2015) demonstrated the antidepressant-like effect of an organoselenium molecule in the tail suspension test (TST) through modulation of the noradrenergic and dopaminergic systems.…”

Section: Introductionmentioning

confidence: 99%

Selanylimidazopyridine Prevents Lipopolysaccharide-Induced Depressive-Like Behavior in Mice by Targeting Neurotrophins and Inflammatory/Oxidative Mediators

et al. 2018

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Inasmuch, as the major depressive disorder (MDD) has been characterized as a heterogeneous disease as the inflammatory processes, neurotrophic factors’ dysfunction and oxidative/nitrosative stress are believed to play a vital role in its establishment. Organoselenium compounds stand out due to their antioxidant, anti-inflammatory, neuroprotective, and antidepressant effects. In this sense, the present study investigated the effect of 3-((4-methoxyphenyl)selanyl)-2-phenylimidazo[1,2-a]pyridine (MPI; 20 and 50 mg/kg, intragastrically) pretreatment [30 min prior lipopolysaccharide (LPS) challenge (0.83 mg/kg)] on acute LPS induced depressive-like behavior, neuroinflammation, and oxidative stress. MPI was able to prevent the increased immobility time induced by LPS on the forced swimming test (FST), the increase in pro-inflammatory cytokines’ expression in the hippocampus (HC) of mice after LPS challenge via NFkB downregulation, and the increase of the reactive oxygen species generation and lipid peroxidation in the prefrontal cortex and HC of mice. It was observed that at the doses tested, MPI protected against reducing levels of BDNF in the cortex and HC of mice challenged with LPS. These observations suggest that the antidepressant-like effect of MPI depends on its capacity to modulate the inflammatory, antioxidant, and neurotrophic systems.

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“…As regards the role of the noradrenergic system on the antidepressant-like action of (octylseleno)-xylofuranoside (OSX), it was shown that pretreatment with an α 1 -adrenoceptor antagonist and an α 2 -adrenoceptor antagonist reversed the anti-immobility effect of OSX in the TST in mice [38]. In addition, the same results were obtained with naloxone (a non-selective antagonist of opioid receptors) in the FST, which also demonstrated the possible contribution of the opioid system in the antidepressant activity of m-trifluoromethyl-diphenyl diselenide [9].…”

Section: Preclinical Studiesmentioning

confidence: 99%

Selenium and manganese in depression – preclinical and clinical studies

Sławińska

Bielecka

Iwaniak

et al. 2017

Current Issues in Pharmacy and Medical Sciences

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According to the World Health Organization estimates, approximately 10% of the world's population is affected by depressive disorders. Furthermore, even in high-income countries, many people with depression are not treated, which can lead to serious health consequences and a global economic loss. Unfortunately, the current pharmacotherapy of depressive disorders is characterized by unsatisfactory efficacy and the therapeutic effect is accompanied by many side effects. For this reason, there is still ongoing worldwide research to find new antidepressant therapies. In recent years, many data have been shown that essential elements demonstrate the antidepressant action and increase the effect of antidepressants. In this paper we present the results from the preclinical and clinical studies published over the years which show the involvement of selenium and manganese in depressive disorders. In this article, the relationship between the amount of these microelements in a diet and depression is reviewed and what's more, the association among these elements in different biomaterial and their relations to depressive symptoms is presented. Additionally, we discuss the possible influence of selenium and manganese on modulating neurotransmitter system involved in depression.

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Involvement of monoaminergic system in the antidepressant-like effect of (octylseleno)-xylofuranoside in the mouse tail suspension test

Cited by 45 publications

References 59 publications

Computational and biological evidences on the serotonergic involvement of SeTACN antidepressant-like effect in mice

Computational and biological evidences on the serotonergic involvement of SeTACN antidepressant-like effect in mice

Selanylimidazopyridine Prevents Lipopolysaccharide-Induced Depressive-Like Behavior in Mice by Targeting Neurotrophins and Inflammatory/Oxidative Mediators

Selenium and manganese in depression – preclinical and clinical studies

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