Involvement Of Mitophagy In Cigarette Smoke Extract (CSE)-Induced Cellular Senescence In Human Bronchial Epithelial Cells (HBEC)

Ito, Saburo; Hara, Hiromochi; Araya, Jun; Mikami, Jiro; Takasaka, Naoki; Yumino, Yoko; Fujii, Satoko; Tsurushige, Chikako; Kojima, Jun; Shimizu, Kenichiro; Numata, Takanori; Ishikawa, Takeo; Kawaishi, Makoto; Saito, Keisuke; Nakayama, Katsutoshi; Kuwano, Kazuyoshi

doi:10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a5099

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2015

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“…Elevated levels of autophagy have been measured in rodents exposed to CS as well as in cell culture models (3,82). Ito et al have observed that knockdown of PINK1 or Parkin knockdown in vitro increased mitochondrial ROS production and cellular senescence (84). In both pulmonary epithelial cells and mice, CS stabilized the mitophagy regulator PINK1 (114).…”

Section: Cigarette Smokementioning

confidence: 99%

Mitochondrial Redox Dysfunction and Environmental Exposures

Caito

Aschner

2015

Antioxidants & Redox Signaling

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Here, we discuss the mechanisms underlying the sensitivity of the mitochondrial respiratory complexes to redox modulation, as well as examine the effects of environmental contaminants that have well-characterized mitochondrial toxicity. The contaminants discussed in this review are some of the most prevalent and potent environmental contaminants that have been linked to neurological dysfunction, altered cellular respiration, and oxidation.

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