Involvement of mitochondrial dynamics and mitophagy in diabetic endothelial dysfunction and cardiac microvascular injury

Zhang, Xiao; Zhou, Hao; Chang, Xing

doi:10.1007/s00204-023-03599-w

Cited by 7 publications

(1 citation statement)

References 132 publications

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“…While autophagy is usually thought to play a protective role in preserving EC function, overactivation can have a damaging effect and lead to cell death [65]. For example, while moderate mitophagy selectively eliminates damaged organelles and can lead to increased ATP production [63,66], overactivation of mitophagy leads to cell death due to no energy supply [67].…”

Section: Role Of Autophagy In Endothelial Cell Survivalmentioning

confidence: 99%

The Role of Autophagy in Vascular Endothelial Cell Health and Physiology

Hu,

Ladowski,

2024

Cells

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Autophagy is a highly conserved cellular recycling process which enables eukaryotes to maintain both cellular and overall homeostasis through the catabolic breakdown of intracellular components or the selective degradation of damaged organelles. In recent years, the importance of autophagy in vascular endothelial cells (ECs) has been increasingly recognized, and numerous studies have linked the dysregulation of autophagy to the development of endothelial dysfunction and vascular disease. Here, we provide an overview of the molecular mechanisms underlying autophagy in ECs and our current understanding of the roles of autophagy in vascular biology and review the implications of dysregulated autophagy for vascular disease. Finally, we summarize the current state of the research on compounds to modulate autophagy in ECs and identify challenges for their translation into clinical use.

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Section: Role Of Autophagy In Endothelial Cell Survivalmentioning

confidence: 99%

The Role of Autophagy in Vascular Endothelial Cell Health and Physiology

Hu,

Ladowski,

2024

Cells

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Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction

Pang,

Dong,

Pang

et al. 2024

Angiogenesis

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As a vital component of blood vessels, endothelial cells play a key role in maintaining overall physiological function by residing between circulating blood and semi-solid tissue. Various stress stimuli can induce endothelial injury, leading to the onset of corresponding diseases in the body. In recent years, the importance of mitochondria in vascular endothelial injury has become increasingly apparent. Mitochondria, as the primary site of cellular aerobic respiration and the organelle for “energy information transfer,” can detect endothelial cell damage by integrating and receiving various external stress signals. The generation of reactive oxygen species (ROS) and mitochondrial dysfunction often determine the evolution of endothelial cell injury towards necrosis or apoptosis. Therefore, mitochondria are closely associated with endothelial cell function, helping to determine the progression of clinical diseases. This article comprehensively reviews the interconnection and pathogenesis of mitochondrial-induced vascular endothelial cell injury in cardiovascular diseases, renal diseases, pulmonary-related diseases, cerebrovascular diseases, and microvascular diseases associated with diabetes. Corresponding therapeutic approaches are also provided. Additionally, strategies for using clinical drugs to treat vascular endothelial injury-based diseases are discussed, aiming to offer new insights and treatment options for the clinical diagnosis of related vascular injuries.

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