Involvement of microRNAs and their potential diagnostic, therapeutic, and prognostic role in hepatocellular carcinoma

Zhou, Yunting; Liu, Fan; Ma, Chunyang; Cheng, qiong

doi:10.1002/jcla.24673

Cited by 13 publications

(7 citation statements)

References 129 publications

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“…ncRNAs play a pivotal role in HCC development and progression, and evidence exists to support their utility as diagnostic and prognostic biomarkers for this disease [49][50][51]. Among ncRNAs, miRNAs have showed similar expression patterns in extensive studies on human and canine HCC [11][12][13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Novel Y RNA-Derived Fragments Can Differentiate Canine Hepatocellular Carcinoma from Hepatocellular Adenoma

Ushio,

Hasan,

Arif

et al. 2023

Animals

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Hepatocellular carcinomas (HCC) are common tumors, whereas hepatocellular adenomas (HCA) are rare, benign tumors in dogs. The aberrant expression of noncoding RNAs (ncRNAs) plays a pivotal role in HCC tumorigenesis and progression. Among ncRNAs, micro RNAs have been widely researched in human HCC, but much less widely in canine HCC. However, Y RNA-derived fragments have yet to be investigated in canine HCC and HCA. This study targeted canine HCC and HCA patients. We used qRT-PCR to determine Y RNA expression in clinical tissues, plasma, and plasma extracellular vesicles, and two HCC cell lines (95-1044 and AZACH). Y RNA was significantly decreased in tissue, plasma, and plasma extracellular vesicles for canine HCC versus canine HCA and healthy controls. Y RNA was decreased in 95-1044 and AZACH cells versus normal liver tissue and in AZACH versus 95-1044 cells. In plasma samples, Y RNA levels were decreased in HCC versus HCA and Healthy controls and increased in HCA versus Healthy controls. Receiver operating characteristic analysis showed that Y RNA could be a promising biomarker for distinguishing HCC from HCA and healthy controls. Overall, the dysregulated expression of Y RNA can distinguish canine HCC from HCA. However, further research is necessary to elucidate the underlying Y RNA-related molecular mechanisms in hepatocellular neoplastic diseases. To the best of our knowledge, this is the first report on the relative expression of Y RNA in canine HCC and HCA.

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Section: Discussionmentioning

confidence: 99%

Novel Y RNA-Derived Fragments Can Differentiate Canine Hepatocellular Carcinoma from Hepatocellular Adenoma

Ushio,

Hasan,

Arif

et al. 2023

Animals

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“…According to the researchers, mutations in the ARID1A gene can lead to the loss of a protein function that initiates a series of changes in the gene's expression, that support the normal cell growth and cell reproduction. As a result, conditions that contribute to the development of liver cancer may occur [24][25][26].…”

Section: Methodsmentioning

confidence: 99%

Genetic Mechanisms of Hepatocellular Carcinoma: Literature Review

Amirkulova,

Derbissalina,

Shanazarov

et al. 2024

Onkol. radiol. Kaz.

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Relevance: Hepatocellular carcinoma (HCC) is the most common form of primary liver malignancy. This form of liver cancer is characterized by rapid progression and poor survival prognosis. Understanding the genetic mechanisms that underlie HCC is of great importance for developing new diagnostic and therapeutic approaches. The study aimed to the genetic factors in the development of hepatocellular carcinoma. Methods: This review used various sources of literature, including scientific articles and reviews. We reviewed the results of scientific and clinical studies published in 2018-2023 and indexed in the PubMed, Cochrane library, Scopus and Web of Science databases, using the keywords “hepatocellular carcinoma,” “genes,” and “genetic predictors.” Inclusion of articles in the review was based on their content and relevance to the research topic. Results: Various genes associated with hepatocellular carcinoma were analyzed, including genes frequently mutated in HCC, as well as genes that play a role in the regulation of cell growth, apoptosis, metastasis, and invasion. Epigenetic changes such as DNA methylation and chromatin modifications have been investigated. The roles of microRNAs, long non-coding RNAs, circulating microparticles and other biomarkers in the diagnosis and prognosis of HCC were also reviewed. Conclusion: The materials and methods used in this review allowed us to cover a wide range of genes and molecular mechanisms associated with hepatocellular carcinoma. Understanding these mechanisms plays an important role in the development of new diagnostic and therapeutic approaches to combat this dangerous form of liver cancer. Further research in this area will help expand our knowledge base and improve the HCC treatment.

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“…Both miR-130b and miR-15a were shown to be overexpressed in HCCs serum when testing for HCC, miR-130b was 87.7% sensitive and 81.4% specific, whereas miR-15b was 98.3% sensitive but only 15.3% specific. Their combination as HCC biomarkers may be good, particularly for early-stage HCC patients with low AFP levels (67). High levels of exosomal miRNA 32-5p expression, which targets PTEN, were observed in HCC patients, with downregulation of miRNA-137 and miRNA-940 (66).…”

Section: Mirnas In Hcc (Clinical Application and Therapeutic Applicat...mentioning

confidence: 99%

Hepatocellular Carcinoma Incidence and Risk Factors: Insights into the Significance of Genetic Heterogeneity

M. A. Ibrahim,

Ghazy,

Youssef

2023

ERU Research Journal

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Regarding mortality rates, hepatocellular carcinoma (HCC) ranks third among all cancers and sixth among all primary malignancies in frequency. Preexisting diseases include hepatitis C, hepatitis B viruses, and nonalcoholic cirrhosis; all these factors increase the risk of developing HCC. Regarding population, Egypt is third in Africa and fifteenth around the globe, making HCC a major issue. The greatest HCV prevalence was formerly seen in Egypt. It is critical to investigate the probable relationship between HCV and HCC. In Egypt, the government has implemented a mass screening program for the detection and treatment of HCV, and this strategy is anticipated to result in a future decline in the incidence of HCC. It is vital to investigate genetic markers that may assist in identifying high-risk groups and, hence, adjust screening technique indications. microRNAs and single nucleotide polymorphisms may influence multiple cellular signaling pathways connected to tumor growth and angiogenesis, making diagnosing, prognosis, and treating HCC easier. As a result, further research is required to understand liver carcinogenesis completely. The current research focuses on HCC, its risk factors, and the examination of gene polymorphisms in affected patients.

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Involvement of microRNAs and their potential diagnostic, therapeutic, and prognostic role in hepatocellular carcinoma

Cited by 13 publications

References 129 publications

Novel Y RNA-Derived Fragments Can Differentiate Canine Hepatocellular Carcinoma from Hepatocellular Adenoma

Novel Y RNA-Derived Fragments Can Differentiate Canine Hepatocellular Carcinoma from Hepatocellular Adenoma

Genetic Mechanisms of Hepatocellular Carcinoma: Literature Review

Hepatocellular Carcinoma Incidence and Risk Factors: Insights into the Significance of Genetic Heterogeneity

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