Involvement of microglial P2X7 receptor in pain modulation
Jing Zhang,
Lei Gao,
Yaoyuan Zhang
et al.
Abstract:BackgroundPain is a rapid response mechanism that compels organisms to retreat from the harmful stimuli and triggers a repair response. Nonetheless, when pain persists for extended periods, it can lead to adverse changes into in the individual’s brain, negatively impacting their emotional state and overall quality of life. Microglia, the resident immune cells in the central nervous system (CNS), play a pivotal role in regulating a variety of pain‐related disorders. Specifically, recent studies have shed light … Show more
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