Involvement of long non‐coding RNAs in the progression of esophageal cancer

Xue, Wenhua; Zheng, Yuanyuan; Shen, Zhibo; Li, Lifeng; Fan, Zhirui; Wang, Wenbin; Zhu, Zhihao; Zhai, Yunkai; Zhao, Jie; Kan, Quancheng

doi:10.1002/cac2.12146

Cited by 13 publications

(12 citation statements)

References 99 publications

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“…Increasing evidence reveals lncRNAs play a critical role in ESCC progression [ 21 ]. Besides well-characterized lncRNAs, potential critical lncRNAs mediating ESCC formation and progression should be examined.…”

Section: Discussionmentioning

confidence: 99%

Long noncoding RNA LIPH-4 promotes esophageal squamous cell carcinoma progression by regulating the miR-216b/IGF2BP2 axis

et al. 2022

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Introduction Esophageal squamous cell carcinoma (ESCC) represents a major malignancy with poor clinical outcomes. Long noncoding RNAs (lncRNAs) are known to regulate the development and progression of multiple cancers. However, how lncRNAs are involved in ESCC is currently undefined. Methods LIPH-4 levels in ESCC tissue specimens and cells were assessed by qRT-PCR. The biological function of LIPH-4 was examined in cell and animal studies, applying CCK-8, EdU, colony formation and flow cytometry assays as well as xenograft model experiments. The underlying mechanisms of action of LIPH-4 were explored through bioinformatics, luciferase reporter assay, RNA-immunoprecipitation assay and immunoblot. Results We identified a novel lncRNA, LIPH-4, which showed elevated amounts in ESCC tissues and positive correlations with increased tumor size and poor prognosis in ESCC patients. Functional studies showed that LIPH-4 promoted the growth, mediated cell cycle progression and inhibited apoptosis in ESCC cells in vitro, and promoted tumor growth in mice. In terms of mechanism, LIPH-4 could bind to miR-216b and act as a competing endogenous RNA (ceRNA) to induce the expression of miR-216’s target gene IGF2BP2. LIPH-4 played an oncogenic role in ESCC through the miR-216b/IGF2BP2 axis. Conclusions This study suggested that LIPH-4 functions as a novel oncogenic lncRNA by acting as a ceRNA for miR-216b to regulate IGF2BP2, indicating LIPH-4 likely constitutes a prognostic biomarker and therapeutic target in ESCC.

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Section: Discussionmentioning

confidence: 99%

Long noncoding RNA LIPH-4 promotes esophageal squamous cell carcinoma progression by regulating the miR-216b/IGF2BP2 axis

et al. 2022

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“…Esophageal squamous cell carcinoma (ESCC) is the sixth leading cause of cancer death worldwide (57,58). To advance the study of non-invasive biomarker detection, Lin et al (59) extracted and analyzed the G-Nchirna in exosomes from the tissues and saliva of mice and ESCC patients.…”

Section: Esophageal Squamous Cell Carcinomamentioning

confidence: 99%

“…Esophageal squamous cell carcinoma (ESCC) is the sixth leading cause of cancer death worldwide ( 57 , 58 ). To advance the study of non-invasive biomarker detection, Lin et al.…”

Section: Applications In Cancer Researchmentioning

confidence: 99%

Extracellular RNA as a kind of communication molecule and emerging cancer biomarker

Tao

Eshraghian

et al. 2022

Front. Oncol.

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Extracellular RNA (exRNA) is a special form of RNA in the body. RNA carries information about genes and metabolic regulation in the body, which can reflect the real-time status of cells. This characteristic renders it a biomarker for disease diagnosis, treatment, and prognosis. ExRNA is transported through extracellular vesicles as a signal medium to mediate communication between cells. Tumor cells can release more vesicles than normal cells, thereby promoting tumor development. Depending on its easy detection, the advantages of non-invasive molecular diagnostic technology can be realized. In this systematic review, we present the types, vectors, and biological value of exRNA. We briefly describe new methods of tumor diagnosis and treatment, as well as the difficulties faced in the progress of such research. This review highlights the groundbreaking potential of exRNA as a clinical biomarker.

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“…It has been proved that lncRNAs play important roles in the pathogenesis of different types of tumors (e.g., ovarian cancer, clear renal cell carcinoma, and colorectal cancer) by regulating target gene expression [ 9–13 ]. Recently, accumulated evidence suggested that many lncRNAs are dysregulated in EC and regulate cell proliferation, apoptosis, and metastasis [ 14 ]. Vascular endothelial growth factor C ( VEGFC ) mRNA stability–associated long noncoding RNA (lncRNA VESTAR) promotes lymphangiogenesis and lymph node metastasis of ESCC by enhancing VEGF-C mRNA stability [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNA TRPM2 antisense RNA as a potential therapeutic target promotes tumorigenesis and metastasis in esophageal cancer

et al. 2022

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Esophageal cancer (EC) is one type of aggressive gastrointestinal cancers. The treatment of EC is challenging. Effective therapeutic targets require development. Long non-coding RNA TRPM2 antisense RNA (LncRNA TRPM2-AS) is considering a novel biomarker and therapeutic target for various types of cancer. However, the role of lncRNA TRPM2-AS in EC remains unknown. This study aimed to illustrate effects of LncRNA TRPM2-AS on EC growth and metastasis and potential underlying molecular mechanisms. LncRNA TRPM2-AS expression was determined in both EC tissues and cell lines by quantitative real-time polymerase-chain reaction (qRT-PCR). Cell proliferation ability was evaluated by cell counting kit-8 and colony formation assays. Cell apoptosis was analyzed by flow cytometry. Cell migration and invasion were determined using transwell. Epithelial–mesenchymal transition (EMT)-related markers expression were determined using qRT-PCR and Western blotting. Furthermore, potential lncRNA TRPM2-AS targeting miRNAs were predicted by public databases. The expression of five selected miRNAs were validated by qRT-PCR. We found that lncRNA TRPM2-AS expression was increased in EC tissues and cell lines compared with respective control. Silencing lncRNA TRPM2-AS suppressed EC cell proliferation, migration, and invasion while promoted cell apoptosis. Moreover, lncRNA TRPM2-AS knockdown reduced neural cadherin, vimentin, and matrix metallopeptidase 9 gene and protein expressions while increased epithelial cadherin expression. Furthermore, lncRNA TRPM2-AS knockdown promoted microRNA (miR)-1291, miR-6852-5p, and miR-138-5p expressions. Taken together, this study for the first time demonstrates that upregulation of lncRNA TRPM2-AS in EC promotes the growth and metastasis of EC likely through interacting with miR-1291, miR-6852-5p, and miR-138-5p.

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Involvement of long non‐coding RNAs in the progression of esophageal cancer

Cited by 13 publications

References 99 publications

Long noncoding RNA LIPH-4 promotes esophageal squamous cell carcinoma progression by regulating the miR-216b/IGF2BP2 axis

Long noncoding RNA LIPH-4 promotes esophageal squamous cell carcinoma progression by regulating the miR-216b/IGF2BP2 axis

Extracellular RNA as a kind of communication molecule and emerging cancer biomarker

Long non-coding RNA TRPM2 antisense RNA as a potential therapeutic target promotes tumorigenesis and metastasis in esophageal cancer

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