1990
DOI: 10.1016/0952-3278(90)90008-9
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Involvement of leukotriene C4 in PAF-induced death in mice

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Cited by 13 publications
(4 citation statements)
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“…Data from in vivo studies suggest that E6080 is a potent 5-lipoxygenasc inhibitor, as already reported [12][13][14], In this in vitro study, it was confirmed that E6080 inhibited the Ag-induced LT release from passively sensitized guinea-pig and human lung fragments and from human basophils, as well as the calcium ionophore A23187-induced LT release from human PMNs and the LTC4 release from rat alveolar macrophages, exposed to phagocytotic stimulation with silica particles.…”
Section: Discussionsupporting
confidence: 66%
See 1 more Smart Citation
“…Data from in vivo studies suggest that E6080 is a potent 5-lipoxygenasc inhibitor, as already reported [12][13][14], In this in vitro study, it was confirmed that E6080 inhibited the Ag-induced LT release from passively sensitized guinea-pig and human lung fragments and from human basophils, as well as the calcium ionophore A23187-induced LT release from human PMNs and the LTC4 release from rat alveolar macrophages, exposed to phagocytotic stimulation with silica particles.…”
Section: Discussionsupporting
confidence: 66%
“…Data from in vivo studies suggest that E6080 is a potent 5-lipoxygenase inhibitor, as already reported [12][13][14]. In this study, we confirmed the in vitro effects of a newly de veloped 5-lipoxygenase inhibitor, E6080 [6-hydroxy-2-(4-sulfamoylbenzylamino)-4,5,7-trimethylbenzothiazole hy drochloride], on LT release and compared them with those of AA861 [2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-l, 4-benzoquinone], a specific and potent 5-lipoxygenase inhibitor [15,16].…”
Section: Introductionmentioning
confidence: 50%
“…into mice activates the A A cascade producing enough 5-LO products to cause death within one hour [7]. W h e n tested in a model of P A F -i n d u c e d mortality, C G S 26529 dose-dependently protected mice when administered at 2, 6 and 18 hr before P A F injection.…”
Section: Resultsmentioning
confidence: 99%
“…The model is useful for evaluating the inflammatory responses of leukocyte mobilization and plasma exudation. PAF-induced mortality, a modification of the method of Tsunoda [7], was used to determine oral activity in mice. Table 1 (Table 2).…”
Section: Ex Vivo and In Vivo Studiesmentioning
confidence: 99%