Involvement of Inositol in Reproduction

Beemster, Patricia; Groenen, Pascal M.W.; Steegers‐Theunissen, R.P.M.

doi:10.1301/00296640260042748

Cited by 91 publications

(70 citation statements)

References 37 publications

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“…20) This inconsistency is probably due to the metabolic conversion of MI to other inositol derivatives in the body. [17][18][19] Under our experiment conditions, MI, at least in part, would be converted to D-chiro-inositol and lead to the stimulation of GLUT4 translocation in skeletal muscle and to a decrease in the plasma glucose level. Pak et al 17) have shown that the conversion of labeled […”

Section: Discussionmentioning

confidence: 99%

“…16) It has been reported that MI can be converted to chiro-inositol in such insulin-sensitive tissues as skeletal muscle, adipose tissue and liver. 13,[17][18][19] Our previous study demonstrated that inositol derivatives other than MI stimulated the glucose uptake in rat L6 myotubes. 20) The results from an immunoblot analysis revealed that at least D-chiro-, L-chiro-, epi-and muco-inositol, and PI stimulated GLUT4 translocation to the plasma membrane in L6 myotubes and also in the skeletal muscle of rats ex vivo.…”

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confidence: 99%

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D-Pinitol andmyo-Inositol Stimulate Translocation of Glucose Transporter 4 in Skeletal Muscle of C57BL/6 Mice

Dang¹,

Mukai²,

Yoshida³

et al. 2010

Bioscience, Biotechnology, and Biochemistry

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

D-Pinitol andmyo-Inositol Stimulate Translocation of Glucose Transporter 4 in Skeletal Muscle of C57BL/6 Mice

Dang¹,

Mukai²,

Yoshida³

et al. 2010

Bioscience, Biotechnology, and Biochemistry

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“…MyoIns appears particularly important for early development (reviewed by [2]): its concentration in the serum of foetuses and newborn infants is several times higher than in adults [45] and its administration during pregnancy reduces the chance to develop gestational diabetes [9,10] and, in the foetuses of curly tail (ct) mutant mice [17], the natural occurrence of spina bifida. It finally has a positive role in reproduction: its levels in the follicular fluid are positively correlated Capsule We have evaluated whether the inclusion of myo-inositol (myoIns) in human embryo culture media may ameliorate embryo quality in IVF cycles by assessing the effect of this molecule on preimplantation development using the mouse embryo assay.…”

Section: Introductionmentioning

confidence: 99%

Improvement of mouse embryo quality by myo-inositol supplementation of IVF media

Colazingari

Fiorenza

Carlomagno³

et al. 2014

J Assist Reprod Genet

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Objective Myo-inositol (myoIns) has a positive role in mammalian development and human reproduction. Since experiments on farming species suggest a similar role in preimplantation development, we evaluated the hypothesis that the inclusion of myoIns in human embryo culture media would produce an increase in embryo quality in IVF cycles, using the mouse embryo assay. Methods To determine the effect of myoIns on completion of preimplantation development in vitro, one-cell embryos of the inbred C57BL/6N mouse strain were produced by ICSI, cultured in human fertilization media in the presence of myoIns (myoIns+) or in its absence (myoIns-) and evaluated morphologically. Daily progression through cleavage stages, blastocyst production and expansion and blastomere number at 96 hours post fertilization were assessed. Results Compared to myoIns-embryos, myoIns+ embryos displayed a faster cleavage rate and by the end of preimplantation development, the majority of myoIns+ blastocysts was expanded and formed by a higher number of blastomeres. Conclusion The presence of myoIns resulted in both an increase in proliferation activity and developmental rate of in vitro cultured early mouse embryos, representing a substantial improvement of culture conditions. These data may identify myoIns as an important supplement for human embryo preimplantation culture.

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“…Myo-inositol is an element involved in calcium-dependent signaling; however, there are intrinsic apoptosis pathways linked to quantitative variations of this compound and the formation of intermediate metabolites such as phosphatidylinositol-3-inositol. The derivatives of myo-inositol, such as phosphatidyl inositol-4,5-bisphosphate, play a role in cellular signaling pathways, steroid synthesis, intracellular calcium regulation, and in the maintenance of cellular integrity (Beemster et al, 2002). In vitro experiments suggest that myo-inositol works as a growth factor and its absence can cause changes in the skin, liver, and intestine (Beach and Flick, 1982).…”

Section: General Aspectsmentioning

confidence: 99%

“…In vitro experiments suggest that myo-inositol works as a growth factor and its absence can cause changes in the skin, liver, and intestine (Beach and Flick, 1982). There is an interest in myo-inositol in the pathogenesis of reproductive disorders such as infertility, miscarriage, preeclampsia, and congenital malformations such as spina bifida and Down's syndrome (Beemster et al, 2002).…”

Section: General Aspectsmentioning

confidence: 99%

Bovine yolk sac: from morphology to metabolomic and proteomic profiles

Galdos-Riveros¹,

Favaron²,

Will³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. In several species, placentation involves the presence of two different membranes responsible for maternal-fetal exchanges: the yolk sac and the chorioallantoic placenta. The yolk sac plays important roles in embryonic survival, mainly during the early stages of gestation. In bovine, it is a transitional membrane that is present until day 50-70 of pregnancy. Herein, we evaluated the morphological and molecular aspects of the yolk sac of bovine embryos during 24 to 52 days of gestation. A total of 69 embryos were allocated into three groups according to the crown-rump length and estimated ages. Yolk sac samples were then subjected to morphological and molecular analysis using mass spectrometry and nuclear magnetic resonance techniques. In contrast to alanine, which was observed only in Group I, during all gestational stages, we identified important metabolites such as aspartate, taurine, glycerophosphocholine, creatinine, creatine, hydrouracil, glutamate, glutamine, lactate, lysine, valine, myo-inositol, cadaverine, and choline. In addition, 314 random sequences of proteins (2015) were identified in the bovine yolk sac, and 47 of these were considered to be specific. Changes in alpha-fetoprotein and carcinoembryonic antigen concentrations during gestation were also evaluated. In conclusion, the majority of these proteins are related to the development of secondary metabolites that are involved in the activation of other proteins and metabolites, and in signaling pathways that are responsible for maternalfetal exchanges, activation of programmed cell death mechanisms, and cellular differentiation, and also in proteins that are responsible for the yolk sac involution that is required to establish chorioallantoic placentation.

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Involvement of Inositol in Reproduction

Cited by 91 publications

References 37 publications

D-Pinitol andmyo-Inositol Stimulate Translocation of Glucose Transporter 4 in Skeletal Muscle of C57BL/6 Mice

D-Pinitol andmyo-Inositol Stimulate Translocation of Glucose Transporter 4 in Skeletal Muscle of C57BL/6 Mice

Improvement of mouse embryo quality by myo-inositol supplementation of IVF media

Bovine yolk sac: from morphology to metabolomic and proteomic profiles

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