Involvement of hypothalamic cyclooxygenase-2, interleukin-1β and melanocortin in the development of docetaxel-induced anorexia in rats

Yamamoto, Kouichi; Asano, Keiko; Ito, Yui; Matsukawa, Naoki; Kim, Seikou; Yamatodani, Atsushi

doi:10.1016/j.tox.2012.07.015

Cited by 8 publications

(5 citation statements)

References 49 publications

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“…In order to validate our hypothesis, we constructed a tumor targeting system of docetaxel based on multiple interactions between indomethacin and PEGylation cleavable PEI (PEG-s-PEI). In this case, IND/PEG-s-PEI nanoassemblies functioned as nanovehicles for DTX, and IND was also employed as COX inhibitor to reverse anorexia induced by docetaxel-based chemotherapy 42 , leading to an IND-DTX combined nanotherapy.…”

Section: Discussionmentioning

confidence: 99%

Smart pH-sensitive nanoassemblies with cleavable PEGylation for tumor targeted drug delivery

Zhao

Лонг

Zhang³

et al. 2017

Sci Rep

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A new acidly sensitive PEGylated polyethylenimine linked by Schiff base (PEG-s-PEI) was designed to render pH-sensitive PEGylation nanoassemblies through multiple interactions with indomethacin and docetaxel (DTX). DTX nanoassemblies driven by PEG-s-PEI thus formulated exhibited an excellent pH-sensitivity PEGylation cleavage performance at extracellular pH of tumor microenvironment, compared to normal tissues, thereby long circulated in blood but were highly phagocytosed by tumor cells. Consequently, this smart pH-sensitive PEGylation cleavage provided an efficient strategy to target tumor microenvironment, in turn afforded superior therapeutic outcome in anti-tumor activity.

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Section: Discussionmentioning

confidence: 99%

Smart pH-sensitive nanoassemblies with cleavable PEGylation for tumor targeted drug delivery

Zhao

Лонг

Zhang³

et al. 2017

Sci Rep

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“…Recently, some investigations found that POMC expression are significantly associated with docetaxel‐induced anorexia, DNA methylation, and morbidity risk in breast cancer . Previously, Stovold et al found that POMC expression predicts poor survival and liver metastases in patients with small‐cell lung cancer .…”

Section: Discussionmentioning

confidence: 99%

POMC maintains tumor-initiating properties of tumor tissue-derived long-term-cultured breast cancer stem cells

et al. 2017

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The identification and understanding of the molecular network of cancer stem cells (CSCs) have had a profound impact on our view of carcinogenesis and treatment strategy. Unfortunately, a major problem is that serial passages of CSCs from clinical solid tumor specimens currently are not available in any lab, and thus, reported data are difficult to confirm and intensively interrogated. Here, we have generated two tumor tissue-derived breast CSC (BCSC) lines that showed prolonged maintenance over 20 serial passages in vitro, while retaining their tumor-initiating biological properties. We then deciphered the intrinsic mechanism using analyses of mRNA expression array profiles. It has been determined that pro-opiomelanocortin (POMC) is closely related with protein phosphorylation mediated by G-protein-coupled estrogen receptor (GPER) in BCSC. Following, knockdown of POMC inhibits properties of mammosphere formation, CD44 CD24 population, CD44 expression, and clonogenicity ability in BCSC. We found that inhibition of POMC attenuates phosphorylation of AKT2 and GSK3β in BCSC. Further in vivo investigations demonstrated that POMC interference regulates proliferation of BCSC-bearing tumors. Combination of the clinical results that POMC positive expression is frequently upregulated in human breast cancer and POMC positivity correlated with a poor prognosis, POMC is a potential therapeutic target for BCSC. In conclusion, we have successfully established two long-term-cultured BCSC from clinical specimens. We further indicated that POMC acts as a potential therapeutic target and prognostic marker for future treatment of BCSC.

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“…Therefore, the inhibition of COX-2 is not consistent like it is with systemic knockout. Yamamoto et al [ 39 ] reported that administrating celecoxib twice per day is more effective than a single treatment. Thus, the inhibition of COX-2 can taper off until the next round of drug administration.…”

Section: Discussionmentioning

confidence: 99%

“…The animals were randomized for peroral administration of vehicle (1 mL/100 g body weight) or the same volume containing celecoxib (30 mg/kg body weight) in physiological saline using a feeding needle every day for 5 weeks before sacrifice. The dose of celecoxib was selected according to a previous study on the effect of COX-2 inhibition in the brain [ 39 ].…”

Section: Methodsmentioning

confidence: 99%

Comparison of pharmacological and genetic inhibition of cyclooxygenase-2: effects on adult neurogenesis in the hippocampal dentate gyrus

et al. 2015

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Inducible cyclooxygenase-2 (COX-2) has received much attention because of its role in neuro-inflammation and synaptic plasticity. Even though COX-2 levels are high in healthy animals, the function of this factor in adult neurogenesis has not been clearly demonstrated. Therefore, we performed the present study to compare the effects of pharmacological and genetic inhibition of COX-2 on adult hippocampal neurogenesis. Physiological saline or the same volume containing celecoxib was administered perorally every day for 5 weeks using a feeding needle. Compared to the control, pharmacological and genetic inhibition of COX-2 reduced the appearance of nestin-immunoreactive neural stem cells, Ki67-positive nuclei, and doublecortin-immunoreactive neuroblasts in the dentate gyrus. In addition, a decrease in phosphorylated cAMP response element binding protein (pCREB) at Ser133 was observed. Compared to pharmacological inhibition, genetic inhibition of COX-2 resulted in significant reduction of neural stem cells, cell proliferation, and neuroblast differentiation as well as pCREB levels. These results suggest that COX-2 is part of the molecular machinery that regulates neural stem cells, cell proliferation, and neuroblast differentiation during adult hippocampal neurogenesis via pCREB. Additionally, genetic inhibition of COX-2 strongly reduced neural stem cell populations, cell proliferation, and neuroblast differentiation in the dentate gyrus compared to pharmacological inhibition.

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Involvement of hypothalamic cyclooxygenase-2, interleukin-1β and melanocortin in the development of docetaxel-induced anorexia in rats

Cited by 8 publications

References 49 publications

Smart pH-sensitive nanoassemblies with cleavable PEGylation for tumor targeted drug delivery

Smart pH-sensitive nanoassemblies with cleavable PEGylation for tumor targeted drug delivery

POMC maintains tumor-initiating properties of tumor tissue-derived long-term-cultured breast cancer stem cells

Comparison of pharmacological and genetic inhibition of cyclooxygenase-2: effects on adult neurogenesis in the hippocampal dentate gyrus

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