Involvement of heme synthesis in the growth stimulation of maize seedlings by 5‐aminolevulinic acid

Yonezawa, Tomoki; Sunohara, Yukari; Matsumoto, Hiroshi

doi:10.1111/wbm.12064

Cited by 8 publications

(3 citation statements)

References 37 publications

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“…For the oxidation resisting role of BR, a decomposition product of heme, it could inhibit protein oxidation in vitro in the presence of a variety of oxidants including superoxide and hydroxyl radicals (Wegiel et al 2014;Xie et al 2015). The heme content was increased significantly by ALA in maize (Z. mays L.) under non-stressful condition (Yonezawa et al 2015). Moreover, in a research of transgenic rice, which overexpressed the FECH gene of Bradyrhizobium japonicum, resulted in increasing activity of FECH, raising content of heme and enhancing tolerance of oxidative stress (Kim et al 2014).…”

Section: Enhanced Antioxidant Defense Systemmentioning

confidence: 99%

5-Aminolevulinic acid (ALA) biosynthetic and metabolic pathways and its role in higher plants: a review

Liao

Dawuda

et al. 2018

Plant Growth Regul

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Crop productivity is restricted by various abiotic stresses such as drought, salinity, heat, and cold. Many efforts have been taken to decrease the inhibition of plant growth by alleviating the abiotic stresses. Exogenous applications of hormones, plant growth regulators, and/or small signaling molecules have been reported as a means to enhance plant resistance to stress. One of the small signaling molecules utilized is 5-aminolevulinic acid (ALA) that has been shown to enhance plant growth under abiotic stress. As a metabolic intermediate in higher plants, ALA is a precursor of all tetrapyrroles such as chlorophyll, heme and siroheme. The pathway towards biosynthesis upstream and the metabolism downstream of ALA contains multiple regulatory points that are affected by positive/negative factors. However, report about the regulatory aspects of the ALA metabolic pathway and the role of ALA in stimulating physiochemical processes in higher plants under stress have not been collated and summarized systematically. In this regard, we summarize recent developments in understanding the mechanisms of plant responses to abiotic stress which are affected by ALA as well as new information on the metabolic pathway of ALA. We find that exogenous application of ALA can enhance some key physiological and biochemical processes in plants such as photosynthesis, nutrient uptake, antioxidant characteristics and osmotic equilibrium, however, more in-depth research on the specific mechanisms are needed.

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Section: Enhanced Antioxidant Defense Systemmentioning

confidence: 99%

5-Aminolevulinic acid (ALA) biosynthetic and metabolic pathways and its role in higher plants: a review

Liao

Dawuda

et al. 2018

Plant Growth Regul

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“…Recently, exogenous application of ALA has been shown to have a positive effect on chlorophyll synthesis in de-etiolated cotyledon of oilseed rape under water-deficit stress ( Liu et al, 2016b ). Moreover, as another metabolic branch downstream of ALA, endogenous heme content was increased significantly by exogenous ALA in maize ( Zea mays L.) under non-stressful conditions ( Yonezawa et al, 2015 ). However, the regulative mechanisms of exogenous ALA to tetrapyrrol biosynthesis pathway and photosynthesis under salt stress have not been evaluated yet.…”

Section: Introductionmentioning

confidence: 99%

5-Aminolevulinic Acid (ALA) Alleviated Salinity Stress in Cucumber Seedlings by Enhancing Chlorophyll Synthesis Pathway

et al. 2018

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5-Aminolevulinic acid (ALA) is a common precursor of tetrapyrroles as well as a crucial growth regulator in higher plants. ALA has been proven to be effective in improving photosynthesis and alleviating the adverse effects of various abiotic stresses in higher plants. However, little is known about the mechanism of ALA in ameliorating the photosynthesis of plant under abiotic stress. In this paper, we studied the effects of exogenous ALA on salinity-induced damages of photosynthesis in cucumber (Cucumis sativus L.) seedlings. We found that the morphology (plant height, leave area), light utilization capacity of PS II [qL, Y(II)] and gas exchange capacity (Pn, gs, Ci, and Tr) were significantly retarded under NaCl stress, but these parameters were all recovered by the foliar application of 25 mg L-1 ALA. Besides, salinity caused heme accumulation and up-regulation of gene expression of ferrochelatase (HEMH) with suppression of other genes involved in chlorophyll synthesis pathway. Exogenously application of ALA under salinity down-regulated the heme content and HEMH expression, but increased the gene expression levels of glutamyl-tRNA reductase (HEMA1), Mg-chelatase (CHLH), and protochlorophyllide oxidoreductase (POR). Moreover, the contents of intermediates involved in chlorophyll branch were increased by ALA, including protoporphyrin IX (Proto IX), Mg-protoporphyrin IX (Mg-Proto IX, protochlorophyllide (Pchlide), and chlorophyll (Chl a and Chl b) under salt stress. Ultrastructural observation of mesophyll cell showed that the damages of photosynthetic apparatus under salinity were fixed by ALA. Collectively, the chlorophyll biosynthesis pathway was enhanced by exogenous ALA to improve the tolerance of cucumber under salinity.

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“…ALA significantly increased yields through root or foliar fertilization in grapevines ( Vitis vinifera ) [ 73 ]. The shoot application of ALA stimulates the growth of maize seedlings [ 74 ]. ALA-based fertilizer can significantly increase the growth of tomato and date palm (Phoenix dactylifera ) [ 75 , 76 , 77 ].…”

Section: Application Of Ala In Agriculture and Medicinementioning

confidence: 99%

Advances in 5-Aminolevulinic Acid Priming to Enhance Plant Tolerance to Abiotic Stress

Tan

Cao

Xia

et al. 2022

IJMS

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Priming is an adaptive strategy that improves plant defenses against biotic and abiotic stresses. Stimuli from chemicals, abiotic cues, and pathogens can trigger the establishment of priming state. Priming with 5-aminolevulinic acid (ALA), a potential plant growth regulator, can enhance plant tolerance to the subsequent abiotic stresses, including salinity, drought, heat, cold, and UV-B. However, the molecular mechanisms underlying the remarkable effects of ALA priming on plant physiology remain to be elucidated. Here, we summarize recent progress made in the stress tolerance conferred by ALA priming in plants and provide the underlying molecular and physiology mechanisms of this phenomenon. Priming with ALA results in changes at the physiological, transcriptional, metabolic, and epigenetic levels, and enhances photosynthesis and antioxidant capacity, as well as nitrogen assimilation, which in turn increases the resistance of abiotic stresses. However, the signaling pathway of ALA, including receptors as well as key components, is currently unknown, which hinders the deeper understanding of the defense priming caused by ALA. In the future, there is an urgent need to reveal the molecular mechanisms by which ALA regulates plant development and enhances plant defense with the help of forward genetics, multi-omics technologies, as well as genome editing technology.

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Involvement of heme synthesis in the growth stimulation of maize seedlings by 5‐aminolevulinic acid

Cited by 8 publications

References 37 publications

5-Aminolevulinic acid (ALA) biosynthetic and metabolic pathways and its role in higher plants: a review

5-Aminolevulinic acid (ALA) biosynthetic and metabolic pathways and its role in higher plants: a review

5-Aminolevulinic Acid (ALA) Alleviated Salinity Stress in Cucumber Seedlings by Enhancing Chlorophyll Synthesis Pathway

Advances in 5-Aminolevulinic Acid Priming to Enhance Plant Tolerance to Abiotic Stress

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